Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sinead A. O'Sullivan"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Externí odkaz:
https://doaj.org/article/72e0b15999854ef7ac8f88ad9646cfef
Autor:
Sinead A. O’Sullivan, Kumlesh K. Dev
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-9 (2017)
Abstract Background Fractalkine/CX3CR1 signalling has been implicated in many neurodegenerative and neurological diseases of the central nervous system (CNS). This signalling pathway plays an important role in regulating reactive oxygen species (ROS)
Externí odkaz:
https://doaj.org/article/b6b262dcf4464a7bb6044003f8dee3c7
Publikováno v:
The Journal of Neuroscience
Krabbe's disease is an infantile neurodegenerative disease, which is affected by mutations in the lysosomal enzyme galactocerebrosidase, leading to the accumulation of its metabolite psychosine. We have shown previously that the S1P receptor agonist
Autor:
Michael Helwig, Ayse Ulusoy, Angela Rollar, Sinead A. O’Sullivan, Shirley S. L. Lee, Helia Aboutalebi, Rita Pinto-Costa, Benjamin Jevans, Michael Klinkenberg, Donato A. Di Monte
Publikováno v:
Science advances 8(35), eabn0356 (2022). doi:10.1126/sciadv.abn0356
Interneuronal transfer and brain spreading of pathogenic proteins are features of neurodegenerative diseases. Pathophysiological conditions and mechanisms affecting this spreading remain poorly understood. This study investigated the relationship bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0615b6d532a4aa9274870c2eeed859d2
Publikováno v:
SSRN Electronic Journal.
The evolution of vertebrates required an energy efficient mechanism of fast nerve conduction. Two events: formation of a myelin sheath – an insulator – and a segmented mode of covering the axon by myelin fulfilled this need. This arrangement,
Autor:
Luke M. Healy, Graham K. Sheridan, Kumlesh K. Dev, Catherine O'Sullivan, Sinead A. O’Sullivan
Publikováno v:
Journal of Neurochemistry. 144:736-747
Sphingosine 1-phosphate receptors (S1PR) are G protein-coupled and compose a family with five subtypes, S1P1R-S1P5R. The drug Gilenya® (Novartis, Basel, Switzerland) (Fingolimod; FTY720) targets S1PRs and was the first oral therapy for patients with
Autor:
Kumlesh K. Dev, Sinead A. O’Sullivan
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-9 (2017)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Fractalkine/CX3CR1 signalling has been implicated in many neurodegenerative and neurological diseases of the central nervous system (CNS). This signalling pathway plays an important role in regulating reactive oxygen species (ROS), as well
Publikováno v:
Glia. 65:1119-1136
Oxidative stress is a pathological condition defined as an imbalance between production and removal of reactive oxygen species. This process causes structural cell damage, disrupts DNA repair and induces mitochondrial dysfunction. Many in vitro studi
Autor:
Sinead A. O’Sullivan, Kumlesh K. Dev
Publikováno v:
Neuropharmacology. 113:597-607
The family of sphingosine-1-phosphate receptors (S1PRs) are G protein-coupled and comprise of five subtypes, S1P1-S1P5. These receptors are activated by the sphingolipid ligand, S1P, which is produced from the phosphorylation of sphingosine by sphing
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 11, p e0187217 (2017)
PLoS ONE, Vol 12, Iss 11, p e0187217 (2017)
Krabbe disease is a fatal rare inherited lipid storage disorder affecting 1:100,000 births. This illness is caused by mutations in the galc gene encoding for the enzyme galactosylceramidase (GALC). Dysfunction of GALC has been linked to the toxic bui