Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sinead A. O'Rourke"'
Autor:
Emilio G. Vozza, Alanna M. Kelly, Clíodhna M. Daly, Sinead A. O’Rourke, Simon R. Carlile, Brenda Morris, Aisling Dunne, Rachel M. McLoughlin
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Staphylococcus aureus is an important human commensal which persistently colonizes up to 30% of the human population, predominantly within the nasal cavity. The commensal lifestyle of S. aureus is complex, and the mechanisms underpinning col
Externí odkaz:
https://doaj.org/article/888283d44aa14af8affc23c6ab520e71
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Nrf2 is a master transcriptional regulator of a number of genes involved in the adaptive response to oxidative stress. Among the genes upregulated by Nrf2, heme oxygenase-1 (HO-1) has received significant attention, given that the products of HO-1-in
Externí odkaz:
https://doaj.org/article/ef23c82e735d4bb0815bca6480ca004d
Autor:
Emilio G. Vozza, Clíodhna M. Daly, Sinead A. O'Rourke, Hannah K. Fitzgerald, Aisling Dunne, Rachel M. McLoughlin
Publikováno v:
mBio, Vol 15, Iss 1 (2024)
ABSTRACTStaphylococcus aureus propensity for intracellular survival presents a challenge to effectively treat infection, with significant evidence suggesting S. aureus can hijack phagocytes for host dissemination, worsening clinical outcomes. Human p
Externí odkaz:
https://doaj.org/article/16cdd9fe1026449d842b7c64ffe09ee9
Autor:
Hannah K. Fitzgerald, Sinead A. O’Rourke, Eva Desmond, Nuno G. B. Neto, Michael G. Monaghan, Miriam Tosetto, Jayne Doherty, Elizabeth J. Ryan, Glen A. Doherty, Derek P. Nolan, Jean M. Fletcher, Aisling Dunne
Publikováno v:
Antioxidants, Vol 11, Iss 1, p 164 (2022)
The extracellular parasite and causative agent of African sleeping sickness Trypanosoma brucei (T. brucei) has evolved a number of strategies to avoid immune detection in the host. One recently described mechanism involves the conversion of host-deri
Externí odkaz:
https://doaj.org/article/daea71fc4daf47e5b167422d9b5c9366
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 6 (2019)
Myocardial infarction is the most common form of acute cardiac injury attributing to heart failure. While there have been significant advances in current therapies, mortality and morbidity remain high. Emphasis on inflammation and extracellular matri
Externí odkaz:
https://doaj.org/article/49c0c995e58e4dee804b9e1ae678daa4
Autor:
Sinead A. O'Rourke, Nuno G.B. Neto, Eimear Devilly, Lianne C. Shanley, Hannah K. Fitzgerald, Michael G. Monaghan, Aisling Dunne
Publikováno v:
Atherosclerosis. 352:35-45
Metabolic reprogramming of innate immune cells is emerging as a key player in the progression of a number of chronic diseases, including atherosclerosis, where high rates of glycolysis correlate with plaque instability. This study aimed to investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466174f5036fb7735d33b56b53d3cd0f
https://doi.org/10.1016/j.atherosclerosis.2022.05.015
https://doi.org/10.1016/j.atherosclerosis.2022.05.015
Publikováno v:
Exp Biol Med (Maywood)
Dysregulated metabolism has long been recognized as a feature of many metabolic disorders. However, recent studies demonstrating that metabolic reprogramming occurs in immune cells have led to a growing interest in the relationship between metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab57b7067e4bd977d11550f216db2c1
https://pubmed.ncbi.nlm.nih.gov/36511089
https://pubmed.ncbi.nlm.nih.gov/36511089
Autor:
Nuno GB Neto, Sinead A O'Rourke, Mimi Zhang, Hannah K Fitzgerald, Aisling Dunne, Michael G Monaghan
Publikováno v:
eLife. 11
In this study, we utilise fluorescence lifetime imaging of NAD(P)H-based cellular autofluorescence as a non-invasive modality to classify two contrasting states of human macrophages by proxy of their governing metabolic state. Macrophages derived fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235bd68c907250ca93f8208cd1e48eac
https://doi.org/10.7554/elife.77373
https://doi.org/10.7554/elife.77373
Autor:
Lianne C. Shanley, Olwyn R. Mahon, Sinead A. O'Rourke, Nuno G.B. Neto, Michael G. Monaghan, Daniel J. Kelly, Aisling Dunne
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bba34e06ace3a6f81590d602ee06954
https://doi.org/10.2139/ssrn.4243936
https://doi.org/10.2139/ssrn.4243936