Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sinead Mulready"'
Autor:
Isabel Najera, G Luoni, Klaus Klumpp, David Bernard Smith, Sophie Le Pogam, Sinead Mulready, Sonal Rajyaguru, Christopher McGuigan, Mary Rose Kelleher, Plinio Perrone, Felice Daverio, Joseph A. Martin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4250-4254
We report the design, synthesis and evaluation of a family of ca 50 phosphoramidate ProTides of the potent anti-HCV compound 4'-azidocytidine (R1479), with variation on the ester, amino acid and aryl moiety of the ProTide. Sub-muM inhibitors of HCV e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bae3515770cc9f3e2d172af1e96f5c
https://doi.org/10.1016/j.bmcl.2009.05.099
https://doi.org/10.1016/j.bmcl.2009.05.099
Autor:
Thorfinnur Gunnlaugsson, Thomas McCabe, Paul E. Kruger, Sinead Mulready, Ann-Marie Fanning, R. Jeremy H. Davies, John E. O'Brien, Paul Jensen, Clarke Stevenson
Publikováno v:
Tetrahedron Letters. 46:3761-3766
The cyclen based pyridine complexes 1Ln – 3Ln (Ln = La(III) and Eu(III)) were synthesised as metallo-ribonuclease mimics and their ability to hydrolytically cleave the phosphodiester of HPNP at 37 °C was investigated using UV–vis spectroscopy, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c95f213714263477511a0220883e5df
https://doi.org/10.1016/j.tetlet.2005.03.150
https://doi.org/10.1016/j.tetlet.2005.03.150
Publikováno v:
Tetrahedron. 60:105-113
The synthesis of several lanthanide complexes from the tris alkylated cyclen (1,4,7,10-tetraazacyclododecane) ligands 1 and 2 is described. The syntheses of 1 and 2 were investigated by means of two different synthetic routes (Method 1 and Method 2).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::009fa4a06e09e42c459aea96fbd0c092
https://doi.org/10.1016/j.tet.2003.10.086
https://doi.org/10.1016/j.tet.2003.10.086
Autor:
R. Jeremy H. Davies, John E. O'Brien, Mark Nieuwenhuyzen, Sinead Mulready, Thorfinnur Gunnlaugsson, Clarke Stevenson
Publikováno v:
Polyhedron. 22:711-724
The glycine–alanine conjugated ligands of cyclen (1,4,7,10,-tetraazacyclododecane) 1 and 2, possessing methyl and benzyl alanine esters respectively, and the corresponding lanthanide complexes 1La, 1Eu, 1Tb, 1Yb, 2La, 2Eu, and 2Tb were designed wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b56bcd45e654899ae92f95dc2ff1ef4
https://doi.org/10.1016/s0277-5387(02)01402-x
https://doi.org/10.1016/s0277-5387(02)01402-x
Publikováno v:
Tetrahedron Letters. 43:8493-8497
The lanthanide ion based macrocyclic complexes 1La, 1Eu and 1Yb, were synthesised by the alkylation of L-alanine derived α-chloroamide, giving a tetrasubstituted GlyAla conjugated azamacrocycle using a 1,4,7,10-tetraazacyclododecane, followed by a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95abfaefa4fac52b4b3a2797d174a011
https://doi.org/10.1016/s0040-4039(02)02071-3
https://doi.org/10.1016/s0040-4039(02)02071-3
Autor:
Romain Viguier, Mark Nieuwenhuyzen, Sinead Mulready, R. Jeremy H. Davies, Clarke Stevenson, Thorfinnur Gunnlaugsson
Publikováno v:
Chem. Commun.. :2136-2137
The lanthanide ion based macrocyclic complexes 1.Ln mimic the hydrophobic nature of ribonucleases, where the lanthanide ions induce the formation of a hydrophobic cavity for 1, giving rise to a large order of magnitude enhancement in the hydrolytic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781e1114c303509f6c0615412760db97
https://doi.org/10.1039/b205349g
https://doi.org/10.1039/b205349g
Autor:
Plinio Perrone, Giovanna M. Luoni, Mary Rose Kelleher, Felice Daverio, Annette Angell, Sinead Mulready, Costantino Congiatu, Sonal Rajyaguru, Joseph A. Martin, Vincent Levêque, Sophie Le Pogam, Isabel Najera, Klaus Klumpp, David B. Smith, Christopher McGuigan
Publikováno v:
Journal of Medicinal Chemistry; Apr2007, Vol. 50 Issue 8, p1840-1849, 10p