Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Sine Reker Hadrup"'
Autor:
Trine Sundebo Meldgaard, Nadia Viborg, Sara Suarez Hernandez, Dario Vazquez Albacete, Tripti Tamhane, Sine Reker Hadrup
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The UV-mediated peptide exchange has enabled the generation of multiple different MHC multimer specificities in parallel, surpassing tedious individual refolding of MHC molecules with peptide ligands. Murine models are acknowledged as an eff
Externí odkaz:
https://doaj.org/article/e97581d077b644a9a3f0cd07f9050092
Autor:
Beatrice Cavalluzzo, Marie Christine Viuff, Siri Amanda Tvingsholm, Concetta Ragone, Carmen Manolio, Angela Mauriello, Franco M. Buonaguro, Maria Lina Tornesello, Francesco Izzo, Alessandro Morabito, Sine Reker Hadrup, Maria Tagliamonte, Luigi Buonaguro
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-14 (2024)
Abstract Background We have recently shown extensive sequence and conformational homology between tumor-associated antigens (TAAs) and antigens derived from microorganisms (MoAs). The present study aimed to assess the breadth of T-cell recognition sp
Externí odkaz:
https://doaj.org/article/232cb0feceb841a0aba8d74cd6d8e5a2
Autor:
Marco Donia, Marie Christine Wulff Westergaard, Sine Reker Hadrup, Kalijn Bol, Inge Marie Svane, Arianna Draghi, Anders Jespersen, Sofie Kirial Mørk, Christina Westmose Yde, Torben Lorentzen, Mohammad Kadivar, Daniela Kleine-Kohlbrecher, Benedetta Albieri, Joachim Stoltenborg Granhøj, Signe Koggersbøl Skadborg, Annie Borch, Nadia Viborg Petersen, Nikolas Thuesen, Ida Svahn Rasmussen, Lars Vibe Andreasen, Rebecca Bach Dohn, Nis Noergaard, Anders Bundgaard Soerensen, Dennis Christensen, Jens Kringelum
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)
Background Neoantigens can serve as targets for T cell-mediated antitumor immunity via personalized neopeptide vaccines. Interim data from our clinical study NCT03715985 showed that the personalized peptide-based neoantigen vaccine EVX-01, formulated
Externí odkaz:
https://doaj.org/article/ba4e7a8820d44fe594ecfd552cb83643
Autor:
Annie Borch, Ibel Carri, Birkir Reynisson, Heli M. Garcia Alvarez, Kamilla K. Munk, Alessandro Montemurro, Nikolaj Pagh Kristensen, Siri A. Tvingsholm, Jeppe Sejerø Holm, Christina Heeke, Keith Henry Moss, Ulla Kring Hansen, Anna-Lisa Schaap-Johansen, Frederik Otzen Bagger, Vinicius Araujo Barbosa de Lima, Kristoffer S. Rohrberg, Samuel A. Funt, Marco Donia, Inge Marie Svane, Ulrik Lassen, Carolina Barra, Morten Nielsen, Sine Reker Hadrup
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundMutation-derived neoantigens are critical targets for tumor rejection in cancer immunotherapy, and better tools for neoepitope identification and prediction are needed to improve neoepitope targeting strategies. Computational tools have ena
Externí odkaz:
https://doaj.org/article/0bbbca7628154c30a577b6a43214db8d
Autor:
Sebastian Rask Hamm, Sunil Kumar Saini, Annemette Hald, Anna V. Vaaben, Natasja Wulff Pedersen, Moises Alberto Suarez-Zdunek, Zitta Barrella Harboe, Helle Bruunsgaard, Isik Somuncu Johansen, Carsten Schade Larsen, Claus Bistrup, Henrik Birn, Søren Schwartz Sørensen, Sine Reker Hadrup, Susanne Dam Nielsen
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-7 (2023)
Abstract Background Kidney transplant recipients receive maintenance immunosuppressive therapy to avoid allograft rejection resulting in increased risk of infections and infection-related morbidity and mortality. Approximately 98% of adults are infec
Externí odkaz:
https://doaj.org/article/83e12673459a4efbae5077b556f816c3
Autor:
Sarunas Tumas, Trine Sundebo Meldgaard, Troels Holger Vaaben, Sara Suarez Hernandez, Annemette Tengstedt Rasmussen, Ruben Vazquez-Uribe, Sine Reker Hadrup, Morten O. A. Sommer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract In this study we performed a step-wise optimization of biologically active IL-2 for delivery using E. coli Nissle 1917. Engineering of the strain was coupled with an in vitro cell assay to measure the biological activity of microbially produ
Externí odkaz:
https://doaj.org/article/1b7a75507437425b9f7c1544ff1af6d3
Autor:
Nadia Viborg, Michail Angelos Pavlidis, Marina Barrio-Calvo, Stine Friis, Thomas Trolle, Anders Bundgaard Sørensen, Christian Bahne Thygesen, Søren Vester Kofoed, Daniela Kleine-Kohlbrecher, Sine Reker Hadrup, Birgitte Rønø
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-16 (2023)
Abstract Recent findings have positioned tumor mutation-derived neoepitopes as attractive targets for cancer immunotherapy. Cancer vaccines that deliver neoepitopes via various vaccine formulations have demonstrated promising preliminary results in p
Externí odkaz:
https://doaj.org/article/018569528672479ca528c27630e5b5be
Autor:
Moises Alberto Suarez-Zdunek, Sunil Kumar Saini, Christian Ross Pedersen, Sebastian Rask Hamm, Annemette Hald, Allan Rasmussen, Jens Georg Hillingsø, Sine Reker Hadrup, Susanne Dam Nielsen
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-6 (2023)
Abstract Background Life-long immunosuppressive treatment after liver transplantation (LT) prevents graft rejection but predisposes the LT recipient to infections. Herpesvirus infections are associated with morbidity and mortality among LT recipients
Externí odkaz:
https://doaj.org/article/ffb307a3e40c4bf7a56799cd338d76bd
Autor:
Marco Donia, Özcan Met, Julie Westerlin Kjeldsen, Sine Reker Hadrup, Inge Marie Svane, Arianna Draghi, Anders Handrup Kverneland, Christina Heeke, Siri Amanda Tvingsholm, Marcus Svensson Frej, Vibeke Mindahl Rafa, Ulla Kring Hansen, Maria Ormhøj, Alexander Tyron, Agnete W P Jensen, Mohammad Kadivar, Amalie Kai Bentzen, Kamilla K Munk, Gitte N Aasbjerg, Jeppe S H Ternander, Tripti Tamhane, Christian Schmess, Samuel A. Funt, Søren Nyboe Jakobsen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)
Background Adoptive cell therapy (ACT) has shown promising results for the treatment of cancer and viral infections. Successful ACT relies on ex vivo expansion of large numbers of desired T-cells with strong cytotoxic capacity and in vivo persistence
Externí odkaz:
https://doaj.org/article/a25dad34aae2492e8875e883c1894921
Autor:
Thomas Morgan Hulen, Christina Friese, Nikolaj Pagh Kristensen, Joachim Stoltenborg Granhøj, Troels Holz Borch, Marlies J. W. Peeters, Marco Donia, Mads Hald Andersen, Sine Reker Hadrup, Inge Marie Svane, Özcan Met
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Checkpoint inhibition (CPI) therapy and adoptive cell therapy with autologous tumor-infiltrating lymphocytes (TIL-based ACT) are the two most effective immunotherapies for the treatment of metastatic melanoma. While CPI has been the dominating therap
Externí odkaz:
https://doaj.org/article/7afe16c86d48470cacf63c8ae355b95e