Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sine R, Hadrup"'
Autor:
Sine R Hadrup, Marieke Griffioen, J H Frederik Falkenburg, Mirjam H M Heemskerk, Marian van de Meent, Michel G D Kester, Kyra J Fuchs, Marcus Göransson, Natasja W Ettienne, Rob C M de Jong, Eva A S Koster, Constantijn J M Halkes, Ferenc Scheeren, Peter van Balen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 12 (2024)
Allogeneic stem cell transplantation (alloSCT) provides a curative treatment option for hematological malignancies. After HLA-matched alloSCT, donor-derived T cells recognize minor histocompatibility antigens (MiHAs), which are polymorphic peptides p
Externí odkaz:
https://doaj.org/article/5ad0d9de316d4c61a49201b465e22f42
Autor:
Alessandro Montemurro, Viktoria Schuster, Helle Rus Povlsen, Amalie Kai Bentzen, Vanessa Jurtz, William D. Chronister, Austin Crinklaw, Sine R. Hadrup, Ole Winther, Bjoern Peters, Leon Eyrich Jessen, Morten Nielsen
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Montemurro et al. present NetTCR-2.0, a convolutional neural network-based tool for predicting the interactions between T cell receptors and MHC-peptide complexes. This tool demonstrates that the best predictions are made when CDR3 α or CDR3 β bind
Externí odkaz:
https://doaj.org/article/0fd24268ab1c4d9e95f4d96aaa1b710a
Autor:
Relinde I. Y. Lieverse, Evert J. Van Limbergen, Cary J. G. Oberije, Esther G. C. Troost, Sine R. Hadrup, Anne-Marie C. Dingemans, Lizza E. L. Hendriks, Franziska Eckert, Crispin Hiley, Christophe Dooms, Yolande Lievens, Monique C. de Jong, Johan Bussink, Xavier Geets, Vincenzo Valentini, Giuliano Elia, Dario Neri, Charlotte Billiet, Amir Abdollahi, David Pasquier, Pierre Boisselier, Ala Yaromina, Dirk De Ruysscher, Ludwig J. Dubois, Philippe Lambin
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background About 50% of non-small cell lung cancer (NSCLC) patients have metastatic disease at initial diagnosis, which limits their treatment options and, consequently, the 5-year survival rate (15%). Immune checkpoint inhibitors (ICI), eit
Externí odkaz:
https://doaj.org/article/3d19c81b16c745a58482aa1902edf103
Autor:
David Hoyos, Roberta Zappasodi, Isabell Schulze, Zachary Sethna, Kelvin César de Andrade, Dean F. Bajorin, Chaitanya Bandlamudi, Margaret K. Callahan, Samuel A. Funt, Sine R. Hadrup, Jeppe S. Holm, Jonathan E. Rosenberg, Sohrab P. Shah, Ignacio Vázquez-García, Britta Weigelt, Michelle Wu, Dmitriy Zamarin, Laura F. Campitelli, Edward J. Osborne, Mark Klinger, Harlan S. Robins, Payal P. Khincha, Sharon A. Savage, Vinod P. Balachandran, Jedd D. Wolchok, Matthew D. Hellmann, Taha Merghoub, Arnold J. Levine, Marta Łuksza, Benjamin D. Greenbaum
Publikováno v:
Hoyos, D, Zappasodi, R, Schulze, I, Sethna, Z, de Andrade, K C, Bajorin, D F, Bandlamudi, C, Callahan, M K, Funt, S A, Hadrup, S R, Holm, J S, Rosenberg, J E, Shah, S P, Vázquez-García, I, Weigelt, B, Wu, M, Zamarin, D, Campitelli, L F, Osborne, E J, Klinger, M, Robins, H S, Khincha, P P, Savage, S A, Balachandran, V P, Wolchok, J D, Hellmann, M D, Merghoub, T, Levine, A J, Łuksza, M & Greenbaum, B D 2022, ' Fundamental immune–oncogenicity trade-offs define driver mutation fitness ', Nature, vol. 606, pp. 172-179 . https://doi.org/10.1038/s41586-022-04696-z
Missense driver mutations in cancer are concentrated in a few hotspots1. Various mechanisms have been proposed to explain this skew, including biased mutational processes2, phenotypic differences3–6 and immunoediting of neoantigens7,8; however, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788159a08120de98426bcab992e37aaa
https://doi.org/10.1038/s41586-022-04696-z
https://doi.org/10.1038/s41586-022-04696-z
Autor:
Kerstin F. Gerer, Michael Erdmann, Sine R. Hadrup, Rikke Lyngaa, Lena-Marie Martin, Reinhard E. Voll, Beatrice Schuler-Thurner, Gerold Schuler, Niels Schaft, Stefanie Hoyer, Jan Dörrie
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 9 (2017)
Background: Merkel cell carcinoma (MCC) is a rare but very aggressive skin tumor that develops after integration of a truncated form of the large T-antigen (truncLT) of the Merkel cell polyomavirus (MCV) into the host’s genome. Therapeutic vaccinat
Externí odkaz:
https://doaj.org/article/3b4ab0c616ca40d1a0ce9e1d7f9a0fcc
Autor:
David, Hoyos, Roberta, Zappasodi, Isabell, Schulze, Zachary, Sethna, Kelvin César, de Andrade, Dean F, Bajorin, Chaitanya, Bandlamudi, Margaret K, Callahan, Samuel A, Funt, Sine R, Hadrup, Jeppe S, Holm, Jonathan E, Rosenberg, Sohrab P, Shah, Ignacio, Vázquez-García, Britta, Weigelt, Michelle, Wu, Dmitriy, Zamarin, Laura F, Campitelli, Edward J, Osborne, Mark, Klinger, Harlan S, Robins, Payal P, Khincha, Sharon A, Savage, Vinod P, Balachandran, Jedd D, Wolchok, Matthew D, Hellmann, Taha, Merghoub, Arnold J, Levine, Marta, Łuksza, Benjamin D, Greenbaum
Publikováno v:
Nature. 606(7912)
Missense driver mutations in cancer are concentrated in a few hotspots
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee1a0a2d5947f6c1e1c6274891165a11
https://pubmed.ncbi.nlm.nih.gov/35641605
https://pubmed.ncbi.nlm.nih.gov/35641605
Autor:
David Hoyos, Roberta Zappasodi, Isabell Schulze, Zachary Sethna, Kelvin César de Andrade, Dean F. Bajorin, Chaitanya Bandlamudi, Margaret K. Callahan, Samuel A. Funt, Sine R. Hadrup, Jeppe S. Holm, Jonathan E. Rosenberg, Sohrab P. Shah, Ignacio Vázquez-García, Britta Weigelt, Michelle Wu, Dmitriy Zamarin, Laura F. Campitelli, Edward J. Osborne, Mark Klinger, Harlan S. Robins, Payal P. Khincha, Sharon A. Savage, Vinod P. Balachandran, Jedd D. Wolchok, Matthew D. Hellmann, Taha Merghoub, Arnold J. Levine, Marta Łuksza, Benjamin D. Greenbaum
Publikováno v:
Nature. 606:E5-E5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d63d3199802a7b376dfb7162949ed15a
https://doi.org/10.1038/s41586-022-04879-8
https://doi.org/10.1038/s41586-022-04879-8
Autor:
Kevin Litchfield, James L. Reading, Clare Puttick, Chris Abbosh, Robert Bentham, Thomas B. K. Watkins, Rachel Rosenthal, Dhruva Biswas, Emilia Lim, Maise AL-Bakir, Virginia Turati, José Afonso Guerra-Assunção, Lucia Conde, Andrew J.S. Furness, Sunil Kumar Saini, Sine R Hadrup, Javier Herrero, Andrew Rowan, Tariq Enver, Matthew D. Hellmann, James Larkin, Samra Turajlic, Sergio Quezada, Nicholas McGranahan, Charles Swanton
Checkpoint inhibitors (CPIs) augment adaptive immunity. Systematic pan-tumor analyses may reveal the relative importance of tumour cell intrinsic and microenvironmental features underpinning CPI sensitization. Here we collated whole-exome and transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::375f23fe6de0a1955fd6473314947cd8
https://doi.org/10.21203/rs.3.rs-76468/v1
https://doi.org/10.21203/rs.3.rs-76468/v1
Autor:
Pleun Hombrink, Sine R Hadrup, Arne Bakker, Michel G D Kester, J H Frederik Falkenburg, Peter A von dem Borne, Ton N M Schumacher, Mirjam H M Heemskerk
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22523 (2011)
T-cell recognition of minor histocompatibility antigens (MiHA) plays an important role in the graft-versus-tumor (GVT) effect of allogeneic stem cell transplantation (allo-SCT). However, the number of MiHA identified to date remains limited, making c
Externí odkaz:
https://doaj.org/article/f01a8f9b9cc748ee88f8c80cb2c7d3b9