Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Sine Mandrup Bertozzi"'
Autor:
Sohail Jahid, Jose A. Ortega, Linh M. Vuong, Isabella Maria Acquistapace, Stephanie J. Hachey, Jessica L. Flesher, Maria Antonietta La Serra, Nicoletta Brindani, Giuseppina La Sala, Jacopo Manigrasso, Jose M. Arencibia, Sine Mandrup Bertozzi, Maria Summa, Rosalia Bertorelli, Andrea Armirotti, Rongsheng Jin, Zheng Liu, Chi-Fen Chen, Robert Edwards, Christopher C.W. Hughes, Marco De Vivo, Anand K. Ganesan
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110641- (2022)
Summary: CDC42 family GTPases (RHOJ, RHOQ, CDC42) are upregulated but rarely mutated in cancer and control both the ability of tumor cells to invade surrounding tissues and the ability of endothelial cells to vascularize tumors. Here, we use computer
Externí odkaz:
https://doaj.org/article/b20a95d5a6444819bbfaaf7b0c218769
Autor:
Juergen Bartelmess, Gesmi Milcovich, Viviana Maffeis, Marta d'Amora, Sine Mandrup Bertozzi, Silvia Giordani
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Photodynamic therapy is currently one of the most promising approaches for targeted cancer treatment. It is based on responses of vital physiological signals, namely, reactive oxygen species (ROS), which are associated with diseased condition develop
Externí odkaz:
https://doaj.org/article/1048005fe31140dc9d0581b323618042
Autor:
Nara Liessi, Emanuela Pesce, Clarissa Braccia, Sine Mandrup Bertozzi, Alessandro Giraudo, Tiziano Bandiera, Nicoletta Pedemonte, Andrea Armirotti
Publikováno v:
JCI Insight, Vol 5, Iss 16 (2020)
In recent years, a number of drugs have been approved for the treatment of cystic fibrosis (CF). Among them, newly released Trikafta, a combination of 3 drugs (VX-661/VX-445/VX-770), holds great promise to radically improve the quality of life for a
Externí odkaz:
https://doaj.org/article/fb3c797c83d64436a3ae7f702dc6767e
Autor:
Andrea Giorgi, Sara Migliarini, Alberto Galbusera, Giacomo Maddaloni, Maddalena Mereu, Giulia Margiani, Marta Gritti, Silvia Landi, Francesco Trovato, Sine Mandrup Bertozzi, Andrea Armirotti, Gian Michele Ratto, Maria Antonietta De Luca, Raffaella Tonini, Alessandro Gozzi, Massimo Pasqualetti
Publikováno v:
Cell Reports, Vol 21, Iss 4, Pp 910-918 (2017)
Summary: Serotonin-producing neurons profusely innervate brain regions via long-range projections. However, it remains unclear whether and how endogenous serotonergic transmission specifically influences regional or global functional activity. We com
Externí odkaz:
https://doaj.org/article/3d2da61cd386432ca67dab2b5837c76d
Autor:
Valeria Capurro, Valeria Tomati, Elvira Sondo, Mario Renda, Anna Borrelli, Cristina Pastorino, Daniela Guidone, Arianna Venturini, Alessandro Giraudo, Sine Mandrup Bertozzi, Ilaria Musante, Fabio Bertozzi, Tiziano Bandiera, Federico Zara, Luis J. V. Galietta, Nicoletta Pedemonte
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5262 (2021)
Deletion of phenylalanine at position 508 (F508del) in the CFTR chloride channel is the most frequent mutation in cystic fibrosis (CF) patients. F508del impairs the stability and folding of the CFTR protein, thus resulting in mistrafficking and prema
Externí odkaz:
https://doaj.org/article/0305434c75504b6b9876d7e023f82674
Autor:
Nicoletta Brindani, Linh M. Vuong, Isabella Maria Acquistapace, Maria Antonietta La Serra, José Antonio Ortega, Marina Veronesi, Sine Mandrup Bertozzi, Maria Summa, Stefania Girotto, Rosalia Bertorelli, Andrea Armirotti, Anand K. Ganesan, Marco De Vivo
Publikováno v:
Journal of Medicinal Chemistry. 66:5981-6001
Autor:
Andrea Armirotti, Debora Russo, Andrea Nuzzi, Paolo Di Fruscia, Daniela Pizzirani, Chiara Pagliuca, Giovanni Bottegoni, Annalisa Fiasella, Ilaria Penna, Jose Antonio Ortega, Elisa Romeo, Francesca Giacomina, Sine Mandrup Bertozzi, Angelo Reggiani, Maria Summa, Anna Carbone, Roberta Giampà, Rosalia Bertorelli, Francesco Berti, Tiziano Bandiera, Luisa Mengatto, Stefano Ponzano, Glauco Tarozzo, Fabio Bertozzi
Publikováno v:
Journal of Medicinal Chemistry
Inhibition of intracellular N-acylethanolamine-hydrolyzing acid amidase (NAAA) activity is a promising approach to manage the inflammatory response under disabling conditions. In fact, NAAA inhibition preserves endogenous palmitoylethanolamide (PEA)
Autor:
Marco De Vivo, Marco Borgogno, Giuliana Ottonello, Sine Mandrup Bertozzi, Annalisa Savardi, Andrea Armirotti, Andrea Contestabile, Laura Cancedda, Alessandra Turci, Jacopo Manigrasso, Corinne Portioli
Publikováno v:
Journal of Medicinal Chemistry
Intracellular chloride concentration [Cl–]i is defective in several neurological disorders. In neurons, [Cl–]i is mainly regulated by the action of the Na+–K+–Cl– importer NKCC1 and the K+–Cl– exporter KCC2. Recently, we have reported t
Autor:
Arianna Colini Baldeschi, Marco Zattoni, Silvia Vanni, Lea Nikolic, Chiara Ferracin, Giuseppina La Sala, Maria Summa, Rosalia Bertorelli, Sine Mandrup Bertozzi, Gabriele Giachin, Paolo Carloni, Maria Laura Bolognesi, Marco De Vivo, Giuseppe Legname
Publikováno v:
Journal of medicinal chemistry 65(13), 8998-9010 (2022). doi:10.1021/acs.jmedchem.2c00205
Dipòsit Digital de la UB
Universidad de Barcelona
Dipòsit Digital de la UB
Universidad de Barcelona
Prion diseases are a group of neurodegenerative disorders characterized by the accumulation of misfolded prion protein (called PrPSc). Although conversion of the cellular prion protein (PrPC) to PrPSc is still not completely understood, most of the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bac9ad2324cdd573822e0af878d5b90
http://hdl.handle.net/2445/188742
http://hdl.handle.net/2445/188742
Autor:
M. De Vivo, Rongsheng Jin, S. J. Hachey, I. M. Acquistapace, Rosalia Bertorelli, Arasu Ganesan, J. L. Flesher, S. Jahid, Jacopo Manigrasso, Nicoletta Brindani, Jose Antonio Ortega, L. M. Vuong, Zhe Liu, M. A. La Serra, Robert A. Edwards, Sine Mandrup Bertozzi, Curtis Chen, Maria Summa, G. La Sala, Christopher C.W. Hughes, Andrea Armirotti, Jose M. Arencibia
Publikováno v:
Cell Rep
Cell reports, vol 39, iss 1
Cell reports, vol 39, iss 1
SUMMARYCDC42 family GTPases (RHOJ, RHOQ, CDC42) are upregulated but rarely mutated in cancer and control both the ability of tumor cells to invade surrounding tissues and the ability of endothelial cells to vascularize tumors. Here we use computer-ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e788e11d6666cbb632d747cd87461b
https://europepmc.org/articles/PMC9128537/
https://europepmc.org/articles/PMC9128537/