Detection of active matriptase using a biotinylated chloromethyl ketone peptide.

Autor: Sine Godiksen, Christoffer Soendergaard, Stine Friis, Jan K Jensen, Jette Bornholdt, Katiuchia Uzzun Sales, Mingdong Huang, Thomas H Bugge, Lotte K Vogel

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e77146 (2013)

Matriptase is a member of the family of type II transmembrane serine proteases that is essential for development and maintenance of several epithelial tissues. Matriptase is synthesized as a single-chain zymogen precursor that is processed into a two

Externí odkaz: https://doaj.org/article/6a99365eb769456299d77c1bb823a3ae

Correction: Low Gene Expression Is an Early Event in Colorectal Carcinogenesis.

Autor: Vibeke Andersen, Ulla Vogel, Sine Godiksen, Franz B. Frenzel, Mona Sæbø, Julian Hamfjord, Elin Kure, Lotte K. Vogel

Publikováno v: PLoS ONE, Vol 8, Iss 9 (2013)

Externí odkaz: https://doaj.org/article/b3cb93022ba44b0398bece27ce6f1cb1

Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis

Autor: Roman Szabo, M. Hatakeyama, Katiuchia Uzzun Sales, Weiping Chen, Silvia Regina Rogatto, Thomas H. Bugge, Lotte K. Vogel, Stine Friis, Sine Godiksen, Joanne E. Konkel, Jorge S. Gutkind, Karina K. Hansen

Publikováno v: Oncogene

The membrane-anchored serine protease, matriptase, is consistently dysregulated in a range of human carcinomas, and high matriptase activity correlates with poor prognosis. Furthermore, matriptase is unique among tumor-associated proteases in that ep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5f565a9eb730a5cc25c54de0495024
https://doi.org/10.1038/onc.2013.563

Intestinal PTGS2 mRNA Levels, PTGS2 Gene Polymorphisms, and Colorectal Carcinogenesis

Autor: Sine Godiksen, Helle Høyer, Tine Iskov Kopp, Ulla Vogel, Franz B. Frenzel, Julian Hamfjord, Inger Marie Bowitz-Lothe, Mona Sæbø, Egil Johnson, Vibeke Andersen, Elin H. Kure, Lotte K. Vogel

Publikováno v: PLoS ONE
Vogel, L K, Saebo, M, Hoyer, H, Kopp, T I, Vogel, U, Godiksen, S, Frenzel, F B, Hamfjord, J, Bowitz-Lothe, I M, Johnson, E, Kure, E H & Andersen, V 2014, ' Intestinal PTGS2 mRNA Levels, PTGS2 Gene Polymorphisms, and Colorectal Carcinogenesis ', PLOS ONE, vol. 9, no. 8, e105254 . https://doi.org/10.1371/journal.pone.0105254
Vogel, L K, Sæbø, M, Høyer, H, Kopp, T I, Vogel, U, Godiksen, S, Frenzel, F B, Hamfjord, J, Bowitz-Lothe, I M, Johnson, E, Kure, E H & Andersen, V 2014, ' Intestinal PTGS2 mRNA levels, PTGS2 gene polymorphisms, and colorectal carcinogenesis ', PLOS ONE, vol. 9, no. 8, e105254 . https://doi.org/10.1371/journal.pone.0105254
PLoS ONE, Vol 9, Iss 8, p e105254 (2014)

BACKGROUND & AIMS: Inflammation is a major risk factor for development of colorectal cancer (CRC). Prostaglandin synthase cyclooxygenase-2 (COX-2) encoded by the PTGS2 gene is the rate limiting enzyme in prostaglandin synthesis and therefore plays a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ec4cd3fdceea3762b3401c8fd74fe4
http://europepmc.org/articles/PMC4148233

A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation

Autor: Stine, Friis, Katiuchia, Uzzun Sales, Sine, Godiksen, Diane E, Peters, Chen-Yong, Lin, Lotte K, Vogel, Thomas H, Bugge

Publikováno v: The Journal of biological chemistry. 288(26)

Matriptase and prostasin are part of a cell surface proteolytic pathway critical for epithelial development and homeostasis. Here we have used a reconstituted cell-based system and transgenic mice to investigate the mechanistic interrelationship betw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f1ff140176287bdafcfeca1c6066732b
https://pubmed.ncbi.nlm.nih.gov/23673661