Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sindhuja Gowrisankaran"'
Autor:
Sindhuja Gowrisankaran, Sébastien Houy, Johanna G. Peña del Castillo, Vicky Steubler, Monika Gelker, Jana Kroll, Paulo S. Pinheiro, Dirk Schwitters, Nils Halbsgut, Arndt Pechstein, Jan R. T. van Weering, Tanja Maritzen, Volker Haucke, Nuno Raimundo, Jakob B. Sørensen, Ira Milosevic
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Endophilins-A are conserved membrane-associated proteins required for endocytosis. Here, the authors report that endophilins-A also promote exocytosis of neurosecretory vesicles by coordinating priming and fusion through intersectin-1, independently
Externí odkaz:
https://doaj.org/article/d12b951e45ac43b1b8a71db762ee3203
Autor:
John D. Murdoch, Christine M. Rostosky, Sindhuja Gowrisankaran, Amandeep S. Arora, Sandra-Fausia Soukup, Ramon Vidal, Vincenzo Capece, Siona Freytag, Andre Fischer, Patrik Verstreken, Stefan Bonn, Nuno Raimundo, Ira Milosevic
Publikováno v:
Cell Reports, Vol 17, Iss 4, Pp 1071-1086 (2016)
Endophilin-A, a well-characterized endocytic adaptor essential for synaptic vesicle recycling, has recently been linked to neurodegeneration. We report here that endophilin-A deficiency results in impaired movement, age-dependent ataxia, and neurodeg
Externí odkaz:
https://doaj.org/article/b3675368bb464b4481786ffb5883f006
Autor:
Zohreh Farsi, Sindhuja Gowrisankaran, Matija Krunic, Burkhard Rammner, Andrew Woehler, Eileen M Lafer, Carsten Mim, Reinhard Jahn, Ira Milosevic
Publikováno v:
eLife, Vol 7 (2018)
Newly-formed synaptic vesicles (SVs) are rapidly acidified by vacuolar adenosine triphosphatases (vATPases), generating a proton electrochemical gradient that drives neurotransmitter loading. Clathrin-mediated endocytosis is needed for the formation
Externí odkaz:
https://doaj.org/article/757bbeb97ee94f8d8eaeb3c74124101c
Autor:
Sindhuja Gowrisankaran, Ira Milosevic
Publikováno v:
IUBMB Life. 72:568-576
The vacuolar H+ -adenosine triphosphatases (vATPases) acidify multiple intracellular organelles, including synaptic vesicles (SVs) and secretory granules. Acidification of SVs represents a critical point during the SV cycle: without acidification, ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d17ac126935e3e1d326ec00189eb7e
https://doi.org/10.1002/iub.2235
https://doi.org/10.1002/iub.2235
Publikováno v:
Journal of molecular biology. 432(4)
The BIN1/Amphiphysin/Rvs (BAR) protein family is an essential part of the cell’s machinery to bend membranes. Bridging integrator 1 (BIN1) is a muscle-enriched BAR protein with an established role in muscle development and skeletal myopathies. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9e936c28aa6e8ee9c70a2696ab29a1
https://pubmed.ncbi.nlm.nih.gov/31857086
https://pubmed.ncbi.nlm.nih.gov/31857086
Autor:
Nuno Raimundo, Nils Halbsgut, Jana Kroll, J. B. Soerensen, Sébastien Houy, Paulo S. Pinheiro, Ira Milosevic, V. Steubler, M. Gelker, J. G. Pena del Castillo, Sindhuja Gowrisankaran
SUMMARYEndophilins-A are conserved endocytic adaptors with membrane curvature-sensing and - inducing properties. We show here that, independently of their role in endocytosis, endophilin-A1 and endophilin-A2 regulate exocytosis of neurosecretory vesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2f5260411879c184ed9f2a13840439
Autor:
Ira Milosevic, Carsten Mim, Eileen M. Lafer, Zohreh Farsi, Sindhuja Gowrisankaran, Matija Krunic, Burkhard Rammner, Andrew Woehler, Reinhard Jahn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77d62211c71b29385f5e4d02855c9ffb
https://doi.org/10.7554/elife.32569.029
https://doi.org/10.7554/elife.32569.029
Autor:
Rachid El Fatimy, Athul Mohan, Anna M. Krichevsky, Erik J. Uhlmann, Sindhuja Gowrisankaran, Ming Yi, Eric G. Marcusson, Hiroaki Wakimoto, Bakhos A. Tannous, Robert M. Stephens, Priya Karmali, Hon Kit Wong, Courtney Onodera, Jun S. Song, Zhiyun Wei
Publikováno v:
Molecular Therapy. 23(7):1234-1247
Using in silico analysis of The Cancer Genome Atlas (TCGA), we identified microRNAs associated with glioblastoma (GBM) survival, and predicted their functions in glioma growth and progression. Inhibition of two “risky” miRNAs, miR-148a and miR-31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95489536c628c6f1bb1d4f0e4bb52a85