Alpha-Synuclein Targeting Therapeutics for Parkinson's Disease and Related Synucleinopathies

Autor: Sindhu Menon, Sabrina Armstrong, Amir Hamzeh, Naomi P. Visanji, Sergio Pablo Sardi, Anurag Tandon

Publikováno v: Frontiers in Neurology, Vol 13 (2022)

α-Synuclein (asyn) is a key pathogenetic factor in a group of neurodegenerative diseases generically known as synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Although the init

Externí odkaz: https://doaj.org/article/a3dc4d1b756f4e508aec3604a1ec394a

The loss of the kinases SadA and SadB results in early neuronal apoptosis and a reduced number of progenitors.

Autor: Pratibha Dhumale, Sindhu Menon, Joanna Chiang, Andreas W Püschel

Publikováno v: PLoS ONE, Vol 13, Iss 4, p e0196698 (2018)

The neurons that form the mammalian neocortex originate from progenitor cells in the ventricular (VZ) and subventricular zone (SVZ). Newborn neurons are multipolar but become bipolar during their migration from the germinal layers to the cortical pla

Externí odkaz: https://doaj.org/article/69a9c2d69e41402ca2753b507732d150

Evaluation of the effect of Moringa peregrina bark on the crystal habit and size of calcium oxalate monohydrate crystals in different stages of crystallization using experimental and theoretical methods

Autor: Laila Hamed Al Haddabi, C. B. Shinisha, Sindhu Menon, Zainab Sulaiman Al Ajmi, Hajar Hassan Al Zaabi, V. P. Jayachandran, Hajar Khalfan Al Mamari

Publikováno v: CrystEngComm. 23:2673-2682

A significant proportion of the world's population is afflicted by kidney stone disease, urolithiasis, often as a chronic, recurring condition. The process of biomineralization leading to urolithiasis can be regulated by various inhibitory molecules.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbc0f85d802dd2ce7ff01b2fc9087432
https://doi.org/10.1039/d1ce00080b

Viral alpha-synuclein knockdown prevents spreading synucleinopathy

Autor: Joel C. Watts, Rikke Hahn Kofoed, Fadl Nabbouh, S. Pablo Sardi, Paul E. Fraser, Tammy Langman, Anurag Tandon, Yasmeen Al-Fahoum, Kristiana Xhima, Lamya S. Shihabuddin, Sindhu Menon, Isabelle Aubert, Howard T.J. Mount

Publikováno v: Brain Communications

The accumulation of aggregated alpha-synuclein (α-syn) in Parkinson's disease, dementia with Lewy bodies and multiple system atrophy is thought to involve a common prion-like mechanism, whereby misfolded α-syn provides a conformational template for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc6005e2483488ec72729d31109d102
https://doi.org/10.1093/braincomms/fcab247

The Sensitivity and Specificity of Parental Report of Concern for Identifying Language Disorder in Children With Craniosynostosis

Autor: David Johnson, Steven A. Wall, Andrew Judge, Sarah Kilcoyne, Louise Dalton, Sarah Overton, Sindhu Menon Rajan

Publikováno v: Kilcoyne, S, Rajan, S M, Dalton, L, Judge, A, Overton, S, Wall, S & Johnson, D 2020, ' The Sensitivity and Specificity of Parental Report of Concern for Identifying Language Disorder in Children With Craniosynostosis ', Journal of Craniofacial Surgery, vol. 32, no. 1, pp. 36-41 . https://doi.org/10.1097/SCS.0000000000006840

Many factors that may co-occur with craniosynostosis, such as oral structural anomalies, hearing impairment, visual impairment, cognitive difficulties and psychosocial factors, may predispose this population to communication difficulties. At the Oxfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd08a1d4da2303e781579d4063ab356
https://pubmed.ncbi.nlm.nih.gov/33038168