Synthesis and biological activity of conformationally restricted indole-based inhibitors of neurotropic alphavirus replication: Generation of a three-dimensional pharmacophore.

Autor: Barraza SJ; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, United States., Sindac JA; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, United States., Dobry CJ; Departments of Internal Medicine and Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, United States., Delekta PC; Departments of Internal Medicine and Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, United States., Lee PH; Vahlteich Medicinal Chemistry Core, University of Michigan, Ann Arbor, MI 48109, United States; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, United States., Miller DJ; Departments of Internal Medicine and Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, United States., Larsen SD; Vahlteich Medicinal Chemistry Core, University of Michigan, Ann Arbor, MI 48109, United States; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: sdlarsen@med.umich.edu.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Aug 15; Vol. 46, pp. 128171. Date of Electronic Publication: 2021 Jun 15.

Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.

Autor: Gurney ME; Tetra Discovery Partners, Inc. , 38 Fulton Street West , Grand Rapids , Michigan 49503 , United States., Nugent RA; Tetra Discovery Partners, Inc. , 38 Fulton Street West , Grand Rapids , Michigan 49503 , United States., Mo X; Tetra Discovery Partners, Inc. , 38 Fulton Street West , Grand Rapids , Michigan 49503 , United States., Sindac JA; Tetra Discovery Partners, Inc. , 38 Fulton Street West , Grand Rapids , Michigan 49503 , United States., Hagen TJ; Department of Chemistry and Biochemistry , Northern Illinois University , 1425 West Lincoln Highway , DeKalb , Illinois 60115 , United States., Fox D 3rd; Beryllium Discovery Corp. , 7869 NE Day Road West , Bainbridge Island , Washington 98110 , United States., O'Donnell JM; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences , University at Buffalo, The State University of New York , Buffalo , New York 14214-8033 , United States., Zhang C; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences , University at Buffalo, The State University of New York , Buffalo , New York 14214-8033 , United States., Xu Y; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences , University at Buffalo, The State University of New York , Buffalo , New York 14214-8033 , United States., Zhang HT; Departments of Behavioral Medicine & Psychiatry and Physiology, Pharmacology & Neuroscience, Rockefeller Neurosciences Institute , West Virginia University Health Sciences Center , 1 Medical Center Drive , Morgantown , West Virginia 26506 , United States., Groppi VE; Michigan Drug Discovery, Life Sciences Institute , University of Michigan , 210 Washtenaw Avenue , Ann Arbor , Michigan 48103 , United States., Bailie M; INDS Inc. , 6111 Jackson Road, Suite 100 , Ann Arbor , Michigan 48103 , United States., White RE; White Global Pharma Consultants , 31 Kinglet Drive , South Cranbury , New Jersey 08512 , United States., Romero DL; Pharma-Vation Consulting, LLC , 1201 Turnberry Ridge Court , Chesterfield , Missouri 63005 , United States., Vellekoop AS; Albany Molecular Research, Inc. , 21 Corporate Circle , Albany , New York 12203 , United States., Walker JR; Albany Molecular Research, Inc. , 21 Corporate Circle , Albany , New York 12203 , United States., Surman MD; Albany Molecular Research, Inc. , 21 Corporate Circle , Albany , New York 12203 , United States., Zhu L; Albany Molecular Research, Inc. , 21 Corporate Circle , Albany , New York 12203 , United States., Campbell RF; Albany Molecular Research, Inc. , 21 Corporate Circle , Albany , New York 12203 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 May 23; Vol. 62 (10), pp. 4884-4901. Date of Electronic Publication: 2019 Apr 23.

Novel indole-2-carboxamide compounds are potent broad-spectrum antivirals active against western equine encephalitis virus in vivo.

Autor: Delekta PC; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Dobry CJ; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Sindac JA; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA., Barraza SJ; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA., Blakely PK; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA., Xiang J; Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan, USA., Kirchhoff PD; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA., Keep RF; Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan, USA., Irani DN; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA., Larsen SD; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA., Miller DJ; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA Department of Microbiology & Immunology, University of Michigan, Ann Arbor, Michigan, USA milldavi@umich.edu.

Publikováno v: Journal of virology [J Virol] 2014 Oct; Vol. 88 (19), pp. 11199-214. Date of Electronic Publication: 2014 Jul 16.

Novel inhibitors of neurotropic alphavirus replication that improve host survival in a mouse model of acute viral encephalitis.

Autor: Sindac JA; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, USA., Yestrepsky BD, Barraza SJ, Bolduc KL, Blakely PK, Keep RF, Irani DN, Miller DJ, Larsen SD

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2012 Apr 12; Vol. 55 (7), pp. 3535-45. Date of Electronic Publication: 2012 Apr 03.