Výsledky vyhledávání - "Sinda Bigenzahn"

Akademický článek

Minor Antigen Disparities Impede Induction of Long Lasting Chimerism and Tolerance through Bone Marrow Transplantation with Costimulation Blockade

Autor: Sinda Bigenzahn, Ines Pree, Christoph Klaus, Nina Pilat, Benedikt Mahr, Elisabeth Schwaiger, Patrick Nierlich, Friedrich Wrba, Thomas Wekerle

Publikováno v: Journal of Immunology Research, Vol 2016 (2016)

Mixed chimerism and tolerance can be successfully induced in rodents through allogeneic bone marrow transplantation (BMT) with costimulation blockade (CB), but varying success rates have been reported with distinct models and protocols. We therefore

Externí odkaz: https://doaj.org/article/3ec33d2db81c48fca68600e03e2789f0

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No augmentation of indoleamine 2,3-dioxygenase (IDO) activity through belatacept treatment in liver transplant recipients

Autor: Alexander Kainz, Thomas Wekerle, Dietmar Fuchs, Sinda Bigenzahn, Ferdinand Muehlbacher, B Juergens, A Koenigsrainer, Gerald Brandacher, Johann Pratschke, T Becker, Benedikt Mahr

Publikováno v: Clinical and Experimental Immunology. 192:233-241

Summary Belatacept is a second-generation cytotoxic T lymphocyte antigen (CTLA)-4 immunoglobulin (Ig) fusion protein approved for immunosuppression in renal transplant recipients. It was designed intentionally to interrupt co-stimulation via CD28 by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f799acf50fa38164c91f379282b5d84
https://doi.org/10.1111/cei.13093

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Akademický článek

Anti-CD154 mAb and rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantation.

Autor: Yannick D Muller, Gang Mai, Philippe Morel, Véronique Serre-Beinier, Carmen Gonelle-Gispert, Gisella Puga Yung, Driss Ehirchiou, Jean-Christophe Wyss, Sinda Bigenzahn, Magali Irla, Christoph Heusser, Déla Golshayan, Jörg D Seebach, Thomas Wekerle, Leo H Bühler

Publikováno v: PLoS ONE, Vol 5, Iss 4, p e10352 (2010)

BACKGROUND: Anti-CD154 (MR1) monoclonal antibody (mAb) and rapamycin (RAPA) treatment both improve survival of rat-to-mouse islet xenograft. The present study investigated the effect of combined RAPA/MR1 treatment on rat-to-mouse islet xenograft surv

Externí odkaz: https://doaj.org/article/7b2f6edb0d8748e6bd2e5084c660d39a

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Akademický článek

Review: Adjuvant bisphosphonates in endocrine-responsive breast cancer: what is their place in therapy?

Autor: Michael Gnant, Peter Blaha, Peter Dubsky, Ruth Exner, Florian Fitzal, Emanuel Sporn, Peter Panhofer, Andrea Dal Borgo, Sinda Bigenzahn, Guenther Steger, Raimund Jakesz

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 1 (2009)

Recent advances in the treatment of early breast cancer have improved clinical outcomes and prolonged survival, especially in women with endocrine-responsive disease. However, cancer therapies including cytotoxic chemotherapy, ovarian suppression, an

Externí odkaz: https://doaj.org/article/b7180a7594b9467988b6dab4282d8b84

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The role of natural killer T cells in costimulation blockade-based mixed chimerism

Autor: Ines Pree, Christoph Klaus, Ferdinand Muehlbacher, Nina Pilat, Thomas Wekerle, Zvonimir Koporc, Masaru Taniguchi, Ulrike Baranyi, Patrick-Nikolaus Nierlich, Sinda Bigenzahn

Publikováno v: Transplant International. 23:1179-1189

Distinct lymphocyte populations have been identified that either promote or impede the establishment of chimerism and tolerance through allogeneic bone marrow transplantation (BMT). Natural killer T (NKT) cells have pleiotropic regulatory properties

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c6eed55635e9f91216d533e1a60ec4b
https://doi.org/10.1111/j.1432-2277.2010.01120.x

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Is Endocrine Therapy Really Pleasant? Considerations about the Long-Term Use of Antihormonal Therapy and Its Benefit/Side Effect Ratio

Autor: E. Sporn, Sinda Bigenzahn, Ursula Pluschnig, Peter Dubsky, Andrea Dal Borgo, Guenther G. Steger, Sebastian F. Schoppmann, Raimund Jakesz, Florian Fitzal, Peter Blaha, Michael Gnant, Thomas Bachleitner-Hofmann, Ruth Exner, O. Riedl, Peter Panhofer

Publikováno v: Breast Care. 4:155-161

Endocrine therapy has become a key part in the adjuvant treatment of hormone responsive breast cancer. The positive effect on relapse risk reduction is well defined, but therapy is not free from bothersome side effects for which estrogen deprivation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8dce874361c0bf5c500d66c0ce548a
https://doi.org/10.1159/000227829

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The Role of Non-Deletional Tolerance Mechanisms in a Murine Model of Mixed Chimerism with Costimulation Blockade

Autor: Peter Blaha, Thomas Wekerle, Edgar Selzer, Friedrich Wrba, Ines Pree, Kathrin Wagner, Sinda Bigenzahn, Christoph Heusser, Zvonimir Koporc, Ferdinand Muehlbacher, Helga Bergmeister

Publikováno v: American Journal of Transplantation. 5:1237-1247

Peripheral and central clonal deletion are important tolerance mechanisms in models using bone marrow transplantation (BMT) with costimulation blockade (CB). However, since tolerance can be found before peripheral deletion is complete and since elimi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d054c24b8140dd6fc8df51337dcea7
https://doi.org/10.1111/j.1600-6143.2005.00862.x

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