Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sina Stern"'
Autor:
Hussein Hamzeh, Katharina Gutbrod, Matthias Geyer, Wolfgang Bönigk, Elena Grahn, Diana N. Raju, Heike Endepols, Heinz G. Körschen, Frank Bradke, Dominik Dittmann, Thomas K. Berger, Johannes M. F. G. Aerts, Marina A. Woeste, Peter Dörmann, Jan N. Hansen, Carina E. Marx, Roger Sandhoff, Dagmar Wachten, Sina Stern, Sophie Schonauer
Publikováno v:
The Journal of Biological Chemistry
The journal of biological chemistry 294(11), 3853-3871 (2019). doi:10.1074/jbc.RA118.006311
Journal of Biological Chemistry, 294(11), 3853-3871. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
The journal of biological chemistry 294(11), 3853-3871 (2019). doi:10.1074/jbc.RA118.006311
Journal of Biological Chemistry, 294(11), 3853-3871. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
The nonlysosomal glucosylceramidase β2 (GBA2) catalyzes the hydrolysis of glucosylceramide to glucose and ceramide. Mutations in the human GBA2 gene have been associated with hereditary spastic paraplegia (HSP), autosomal-recessive cerebellar ataxia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d15045280ed8ce4c2e5661f40ffa912
https://doi.org/10.1074/jbc.ra118.006311
https://doi.org/10.1074/jbc.ra118.006311
RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury
Autor:
Sina Stern, Emily E. Handley, Sebastian Dupraz, Cord Brakebusch, Jessica M. Gonyer, Brett J. Hilton, Frank Bradke, Emily R. Burnside
Publikováno v:
Neuron 109(21), 3436-3455.e9 (2021). doi:10.1016/j.neuron.2021.08.014
Stern, S, Hilton, B J, Burnside, E R, Dupraz, S, Handley, E E, Gonyer, J M, Brakebusch, C & Bradke, F 2021, ' RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury ', Neuron, vol. 109, no. 21, pp. 3436-3455 . https://doi.org/10.1016/j.neuron.2021.08.014
Stern, S, Hilton, B J, Burnside, E R, Dupraz, S, Handley, E E, Gonyer, J M, Brakebusch, C & Bradke, F 2021, ' RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury ', Neuron, vol. 109, no. 21, pp. 3436-3455 . https://doi.org/10.1016/j.neuron.2021.08.014
An inhibitory extracellular milieu and neuron-intrinsic processes prevent axons from regenerating in the adult central nervous system (CNS). Here we show how the two aspects are interwoven. Genetic loss-of-function experiments determine that the smal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36676c5e46932a873a389cf9bf79a94a
https://doi.org/10.1016/j.neuron.2021.08.014
https://doi.org/10.1016/j.neuron.2021.08.014
Autor:
Sina Stern, Frank Bradke, Sebastian Dupraz, Andreas Husch, Brett J. Hilton, C.H. Coles, Cord Brakebusch, Telma E. Santos
Publikováno v:
Dupraz, S, Hilton, B J, Husch, A, Santos, T E, Coles, C H, Stern, S, Brakebusch, C & Bradke, F 2019, ' RhoA Controls Axon Extension Independent of Specification in the Developing Brain ', Current biology : CB, vol. 29, no. 22, pp. 3874-3886 . https://doi.org/10.1016/j.cub.2019.09.040
Current biology 29(22), 3874-3886.e9 (2019). doi:10.1016/j.cub.2019.09.040
Current biology 29(22), 3874-3886.e9 (2019). doi:10.1016/j.cub.2019.09.040
Summary The specification of an axon and its subsequent outgrowth are key steps during neuronal polarization, a prerequisite to wire the brain. The Rho-guanosine triphosphatase (GTPase) RhoA is believed to be a central player in these processes. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1078f2d06057c8606daaeb49d0f7fd
https://curis.ku.dk/portal/da/publications/rhoa-controls-axon-extension-independent-of-specification-in-the-developing-brain(b173f272-01ae-49d4-b908-4630138303be).html
https://curis.ku.dk/portal/da/publications/rhoa-controls-axon-extension-independent-of-specification-in-the-developing-brain(b173f272-01ae-49d4-b908-4630138303be).html
Autor:
Sina Stern, Kevin C. Flynn, Michele Curcio, Walter Witke, Brett J. Hilton, Christine B. Gurniak, Frank Bradke, Barbara Schaffran, Molly J.E. Larson, Claudia J. Laskowski, Sebastian Dupraz, Andrea Tedeschi, Telma E. Santos
Publikováno v:
Neuron 103(6), 1073-1085.e6 (2019). doi:10.1016/j.neuron.2019.07.007
Summary Injured axons fail to regenerate in the adult CNS, which contrasts with their vigorous growth during embryonic development. We explored the potential of re-initiating axon extension after injury by reactivating the molecular mechanisms that d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07de3102c075dac51ac6dc9b6a076d7
https://pubmed.ncbi.nlm.nih.gov/31557454
https://pubmed.ncbi.nlm.nih.gov/31557454
Publikováno v:
The Journal of Neuroscience. 29:4512-4518
Neuronal motility relies on actin treadmilling. In addition to regulating cytoskeletal dynamics in the cytoplasm, actin modulates nuclear gene expression. We present a hitherto unappreciated cross talk of actin signaling with gene expression governin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe504521f3254d06884b2ead7a517061
https://doi.org/10.1523/jneurosci.0333-09.2009
https://doi.org/10.1523/jneurosci.0333-09.2009
Autor:
Heinz Schwarz, Sina Stern, Christine Stritt, Alfred Nordheim, Thomas Manke, Daniela Sinske, Bernd Knöll, Martin Vingron, Kai Harting
Publikováno v:
Nature Neuroscience. 12:418-427
In neurons, serum response factor (SRF)-directed transcription regulates migration, axon pathfinding and synapse function. We found that forebrain-specific, neuron-restricted SRF ablation in mice elevated oligodendrocyte precursors while inhibiting t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd40abbd2fed25de8de4e708c58f8f0
https://doi.org/10.1038/nn.2280
https://doi.org/10.1038/nn.2280
Autor:
Bernd Knöll, Sina Stern
Publikováno v:
Molecular Brain
Molecular brain 7(1), 86 (2014). doi:10.1186/s13041-014-0086-6
Molecular brain 7(1), 86 (2014). doi:10.1186/s13041-014-0086-6
Background CNS axon regeneration inhibitors such as Nogo and CSPGs (Chondroitin Sulfate Proteoglycans) are major extrinsic factors limiting outgrowth of severed nerve fibers. However, knowledge on intracellular signaling cascades and gene expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98897de2229ffd46096aff25f8d143da
http://europepmc.org/articles/PMC4243276
http://europepmc.org/articles/PMC4243276
Autor:
Martin Kerschensteiner, Jochen Herms, Emily E. Weigand, Tatjana Kleele, Arthur Konnerth, Sina Stern, Thomas Misgeld, Ronald Naumann, Leanne Godinho, Rosa Maria Karl, Philip R. Williams, Derron L. Bishop, Frank Bradke, Petar Marinković, Peter Engerer, Jana Hartmann
Publikováno v:
Nature Communications
Nature Communications 5(1), 4827 (2014). doi:10.1038/ncomms5827
Nature Communications 5(1), 4827 (2014). doi:10.1038/ncomms5827
Microtubule dynamics in neurons play critical roles in physiology, injury and disease and determine microtubule orientation, the cell biological correlate of neurite polarization. Several microtubule binding proteins, including end-binding protein 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117edd01ebdc277d35e5a5370f0ee58e
https://pubmed.ncbi.nlm.nih.gov/25219969
https://pubmed.ncbi.nlm.nih.gov/25219969
Autor:
Alfred Nordheim, Simone Di Giovanni, Sina Stern, Stefan Kochanek, Bernd Knöll, Ulrike Naumann, Daniela Sinske, Stephanie Haverkamp, Andrea Tedeschi
Publikováno v:
The journal of neuroscience 33(48), 18836-18848 (2013). doi:10.1523/JNEUROSCI.3029-13.2013
Axonal injury generates growth inert retraction bulbs with dynamic cytoskeletal properties that are severely compromised. Conversion of “frozen” retraction bulbs into actively progressing growth cones is a major aim in axon regeneration. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01755a04cebb7c1ea1d3c006a3ba2619
https://pub.dzne.de/record/141401
https://pub.dzne.de/record/141401
Autor:
Walter Witke, Farida Hellal, Alisa E. Shaw, Sonja Jacob, Roland Wedlich-Söldner, Frank Bradke, James R. Bamburg, Liane Meyn, Sina Stern, Sebastian Dupraz, J. Victor Small, Sabina Tahirovic, Christine B. Gurniak, Kevin C. Flynn, Boyan K. Garvalov, Dorothee Neukirchen
Publikováno v:
Neuron 76(6), 1091-1107 (2012). doi:10.1016/j.neuron.2012.09.038
SummaryNeurites are the characteristic structural element of neurons that will initiate brain connectivity and elaborate information. Early in development, neurons are spherical cells but this symmetry is broken through the initial formation of neuri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebbfff3ead9e3bc096e6c5cd01c41cb1
https://pubmed.ncbi.nlm.nih.gov/23259946
https://pubmed.ncbi.nlm.nih.gov/23259946