Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Sina Khorsand"'
Publikováno v:
Methods. 167:92-104
Second-harmonic generation (SHG) is a biophysical tool that senses ligand-induced conformational changes in biomolecules. The Biodesy Delta™ has been developed as a high-throughput screening platform to monitor conformational changes in proteins an
Publikováno v:
Frontiers in Chemical Biology, Vol 3 (2024)
Engaging the immune sensing Stimulator of Interferon Genes (STING) pathway has emerged as a potentially powerful approach to cancer therapy. However, current STING agonists lack stability and specificity, resulting in toxic adverse effects and disapp
Externí odkaz:
https://doaj.org/article/944f43a34c904b5abb486d3aa3780dfc
Autor:
Milton To, Pete Yeung, Michael Fox, Mikhail Hammond, Fiore Cattaruzza, Ayesha Nazeer, Caitlin Koski, Lucas Liu, Sina Khorsand, Deena Rennerfeldt, Kari Morrissey, Zachary Lange, Ming Dong, Sharon Lam, Mika K. Derynck, Bryan A. Irving, Volker Schellenberger
Publikováno v:
Molecular Cancer Therapeutics. 20:P193-P193
Background: TCEs are effective in leukemias, but have been limited in solid tumors due to on-target, off-tumor toxicity. Attempts to circumvent cytokine release syndrome (CRS), including step-up dosing and complex designs, have had limited success du
Autor:
Gabriel Mercado, Paul T. Wilder, Joshua Salafsky, Sina Khorsand, Alexander D. MacKerell, Kristen M. Varney, Que N. Van, Andrew G. Stephen, Frank McCormick, Ben Moree, Wenbo Yu, David J. Weber, Patrick Alexander, Elizabeth Donohue
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 35
Second harmonic generation (SHG) is an emergent biophysical method that sensitively measures real-time conformational change of biomolecules in the presence of biological ligands and small molecules. This study describes the successful implementation
Autor:
Xu Wang, Jonathan Wilhelm, Wei Li, Suxin Li, Zhaohui Wang, Gang Huang, Jian Wang, Houliang Tang, Sina Khorsandi, Zhichen Sun, Bret Evers, Jinming Gao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Stimuli-responsive nanomaterials offer the opportunity to exploit nanoscale cooperativity to improve the precision of diagnostic or therapeutic outcomes. Here, the authors report the design, synthesis and characterization of a series of degradable ul
Externí odkaz:
https://doaj.org/article/9d311122c77848918b4ada92cf5fbb74