Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sina K. Stumpf"'
Autor:
Stefan A. Berghoff, Tim Düking, Lena Spieth, Jan Winchenbach, Sina K. Stumpf, Nina Gerndt, Kathrin Kusch, Torben Ruhwedel, Wiebke Möbius, Gesine Saher
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-13 (2017)
Abstract In neuroinflammatory disorders such as multiple sclerosis, the physiological function of the blood-brain barrier (BBB) is perturbed, particularly in demyelinating lesions and supposedly secondary to acute demyelinating pathology. Using the t
Externí odkaz:
https://doaj.org/article/d7f11a965962441290665d029f07d603
Autor:
Stefan A. Berghoff, Nina Gerndt, Jan Winchenbach, Sina K. Stumpf, Leon Hosang, Francesca Odoardi, Torben Ruhwedel, Carolin Böhler, Benoit Barrette, Ruth Stassart, David Liebetanz, Payam Dibaj, Wiebke Möbius, Julia M. Edgar, Gesine Saher
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Cholesterol is important for axonal myelination during development. Here the authors show that cholesterol levels are reduced in a cuprizone mouse model of multiple sclerosis and that dietary cholesterol supplementation enhances remyelination and rec
Externí odkaz:
https://doaj.org/article/3ee45ebdd5304a2ead8ae8d4b159b5bf
Autor:
Jan Winchenbach, Tim Düking, Stefan A. Berghoff, Sina K. Stumpf, Swen Hülsmann, Klaus-Armin Nave, Gesine Saher
Publikováno v:
F1000Research, Vol 5 (2016)
Background: Studying astrocytes in higher brain functions has been hampered by the lack of genetic tools for the efficient expression of inducible Cre recombinase throughout the CNS, including the neocortex. Methods: Therefore, we generated BAC trans
Externí odkaz:
https://doaj.org/article/53c8f73488c14ec299224e06b6b62fe4
Autor:
Katharina Kronenberg, Thomas Michaelis, Jeong-Seop Rhee, Katrin I. Willig, Lena Spieth, Torben Ruhwedel, Sina K. Stumpf, Takashi Watanabe, Sabine Hofer, Niels Kruse, Tim Düking, Christine Stadelmann, Gesine Saher, Jan Winchenbach, Stefan A. Berghoff, Susana Minguet, Wiebke Möbius, Christian von der Brelie, Ali H Shaib, Nina Gerndt, Peter Michels, Jens Frahm, Petra Hülper, Uwe Karst
Publikováno v:
Neuro-oncology Advances
Neuro-Oncology Advances
Neuro-Oncology Advances
Background Pharmaceutical intervention in the CNS is hampered by the shielding function of the blood–brain barrier (BBB). To induce clinical anesthesia, general anesthetics such as isoflurane readily penetrate the BBB. Here, we investigated whether
Autor:
Wiebke Möbius, Nina Gerndt, Sina K. Stumpf, Torben Ruhwedel, Lena Spieth, Kathrin Kusch, Stefan A. Berghoff, Tim Düking, Jan Winchenbach, Gesine Saher
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-13 (2017)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
In neuroinflammatory disorders such as multiple sclerosis, the physiological function of the blood-brain barrier (BBB) is perturbed, particularly in demyelinating lesions and supposedly secondary to acute demyelinating pathology. Using the toxic non-
Autor:
Lennart Schlaphoff, Gesine Saher, Annette Bley, Lennart V. Schneider, Jutta Gärtner, Heiko Röhse, Kathrin Kusch, Dinah Burfeind, Andrea Trevisiol, Stefan A. Berghoff, Klaus-Armin Nave, Lena Spieth, Steffi Dreha-Kulaczewski, Wiebke Möbius, Tim Düking, Sina K. Stumpf, Philipp Guder, Miso Mitkovski, Jonas Denecke, Torben Ruhwedel
Publikováno v:
Acta Neuropathologica
Pelizaeus–Merzbacher disease (PMD) is an untreatable and fatal leukodystrophy. In a model of PMD with perturbed blood–brain barrier integrity, cholesterol supplementation promotes myelin membrane growth. Here, we show that in contrast to the mous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0b895fadae2c1b5ef171128693ebaf
https://hdl.handle.net/21.11116/0000-000D-2F0B-421.11116/0000-0003-54FF-021.11116/0000-0003-5501-C
https://hdl.handle.net/21.11116/0000-000D-2F0B-421.11116/0000-0003-54FF-021.11116/0000-0003-5501-C
Autor:
Lennart Schlaphoff, Jutta Gärtner, Sina K. Stumpf, Lena Spieth, Klaus-Armin Nave, Gesine Saher, Kathrin Kusch, Torben Ruhwedel, Lennart V. Schneider, Heiko Röhse, Jonas Denecke, Stefan A. Berghoff, Wiebke Möbius, Miso Mitkovski, Dinah Burfeind, Steffi Dreha-Kulaczewski, Philipp Guder, Andrea Trevisiol, Tim Düking, Annette Bley
Publikováno v:
Acta Neuropathologica. 138:673-674
peerReviewed
Autor:
Sina K. Stumpf, Gesine Saher
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1851:1083-1094
The largest pool of free cholesterol in mammals resides in myelin membranes. Myelin facilitates rapid saltatory impulse propagation by electrical insulation of axons. This function is achieved by ensheathing axons with a tightly compacted stack of me
Autor:
Francesca Odoardi, Nina Gerndt, Benoit Barrette, Gesine Saher, Stefan A. Berghoff, Torben Ruhwedel, Wiebke Möbius, Sina K. Stumpf, Carolin Böhler, Leon Hosang, Julia M. Edgar, Jan Winchenbach, Ruth M. Stassart, David Liebetanz, Payam Dibaj
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Multiple Sclerosis (MS) is an inflammatory demyelinating disorder in which remyelination failure contributes to persistent disability. Cholesterol is rate-limiting for myelin biogenesis in the developing CNS; however, whether cholesterol insufficienc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e11f11c3bd7749bb0eb637cdd1c394
http://resolver.sub.uni-goettingen.de/purl?gs-1/14258
http://resolver.sub.uni-goettingen.de/purl?gs-1/14258
Autor:
Stefan A. Berghoff, Tim Düking, Gesine Saher, Sina K. Stumpf, Jan Winchenbach, Klaus-Armin Nave, Swen Hülsmann
Publikováno v:
F1000Research
Background: Studying astrocytes in higher brain functions has been hampered by the lack of genetic tools for the efficient expression of inducible Cre recombinase throughout the CNS, including the neocortex. Methods: Therefore, we generated BAC trans