Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sina Hembach"'
Autor:
Sina Hembach, Sebastian Schmidt, Tanja Orschmann, Ingo Burtscher, Heiko Lickert, Florian Giesert, Daniela Vogt Weisenhorn, Wolfgang Wurst
Publikováno v:
Neurobiology of Disease, Vol 194, Iss , Pp 106474- (2024)
A key pathological feature of Parkinson’s Disease (PD) is the progressive degeneration of dopaminergic neurons (DAns) in the substantia nigra pars compacta. Considering the major role of EN1 in the development and maintenance of these DAns and the
Externí odkaz:
https://doaj.org/article/a1d1e4b677f54221bf0732ca52ab5f8d
Autor:
Sebastian Schmidt, Constantin Stautner, Duc Tung Vu, Alexander Heinz, Martin Regensburger, Ozge Karayel, Dietrich Trümbach, Anna Artati, Sabine Kaltenhäuser, Mohamed Zakaria Nassef, Sina Hembach, Letyfee Steinert, Beate Winner, Winkler Jürgen, Martin Jastroch, Malte D. Luecken, Fabian J. Theis, Gil Gregor Westmeyer, Jerzy Adamski, Matthias Mann, Karsten Hiller, Florian Giesert, Daniela M. Vogt Weisenhorn, Wolfgang Wurst
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Sporadic Parkinson’s Disease (sPD) is a progressive neurodegenerative disorder caused by multiple genetic and environmental factors. Mitochondrial dysfunction is one contributing factor, but its role at different stages of disease progress
Externí odkaz:
https://doaj.org/article/221c463f9fd24a92948d727c0c8d5a38
Autor:
Sebastian Schmidt, Malte D. Luecken, Dietrich Trümbach, Sina Hembach, Kristina M. Niedermeier, Nicole Wenck, Klaus Pflügler, Constantin Stautner, Anika Böttcher, Heiko Lickert, Ciro Ramirez-Suastegui, Ruhel Ahmad, Michael J. Ziller, Julia C. Fitzgerald, Viktoria Ruf, Wilma D. J. van de Berg, Allert J. Jonker, Thomas Gasser, Beate Winner, Jürgen Winkler, Daniela M. Vogt Weisenhorn, Florian Giesert, Fabian J. Theis, Wolfgang Wurst
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-25 (2022)
Here, the authors reveal using single-cell RNA sequencing that Parkinson’s disease (PD) patient-derived neuronal cells show altered primary cilia morphology and signaling suggesting cilia dysfunction may underlie PD pathogenesis.
Externí odkaz:
https://doaj.org/article/b648848b74c14840be9be48f8be10660
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons
Autor:
Jessica Giehrl‐Schwab, Florian Giesert, Benedict Rauser, Chu Lan Lao, Sina Hembach, Sandrine Lefort, Ignacio L Ibarra, Christina Koupourtidou, Malte Daniel Luecken, Dong‐Jiunn Jeffery Truong, Judith Fischer‐Sternjak, Giacomo Masserdotti, Nilima Prakash, Jovica Ninkovic, Sabine M Hölter, Daniela M Vogt Weisenhorn, Fabian J Theis, Magdalena Götz, Wolfgang Wurst
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 5, Pp 1-20 (2022)
Abstract Direct reprogramming based on genetic factors resembles a promising strategy to replace lost cells in degenerative diseases such as Parkinson's disease. For this, we developed a knock‐in mouse line carrying a dual dCas9 transactivator syst
Externí odkaz:
https://doaj.org/article/d6d64f7bdd884a3b9299b97fa956cf9b
Autor:
Sebastian Schmidt, Malte D. Luecken, Dietrich Trümbach, Sina Hembach, Kristina M. Niedermeier, Nicole Wenck, Klaus Pflügler, Constantin Stautner, Anika Böttcher, Heiko Lickert, Ciro Ramirez-Suastegui, Ruhel Ahmad, Michael J. Ziller, Julia C. Fitzgerald, Viktoria Ruf, Wilma D. J. van de Berg, Allert J. Jonker, Thomas Gasser, Beate Winner, Jürgen Winkler, Daniela M. Vogt Weisenhorn, Florian Giesert, Fabian J. Theis, Wolfgang Wurst
Publikováno v:
Nature Communications, 13(1):4819. Nature Publishing Group UK
Schmidt, S, Luecken, M D, Trümbach, D, Hembach, S, Niedermeier, K M, Wenck, N, Pflügler, K, Stautner, C, Böttcher, A, Lickert, H, Ramirez-Suastegui, C, Ahmad, R, Ziller, M J, Fitzgerald, J C, Ruf, V, van de Berg, W D J, Jonker, A J, Gasser, T, Winner, B, Winkler, J R, Vogt Weisenhorn, D M, Giesert, F, Theis, F J & Wurst, W 2022, ' Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease ', Nature Communications, vol. 13, no. 1, 4819 . https://doi.org/10.1038/s41467-022-32229-9
Nature Communications 13(1), 4819 (2022). doi:10.1038/s41467-022-32229-9
Schmidt, S, Luecken, M D, Trümbach, D, Hembach, S, Niedermeier, K M, Wenck, N, Pflügler, K, Stautner, C, Böttcher, A, Lickert, H, Ramirez-Suastegui, C, Ahmad, R, Ziller, M J, Fitzgerald, J C, Ruf, V, van de Berg, W D J, Jonker, A J, Gasser, T, Winner, B, Winkler, J R, Vogt Weisenhorn, D M, Giesert, F, Theis, F J & Wurst, W 2022, ' Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease ', Nature Communications, vol. 13, no. 1, 4819 . https://doi.org/10.1038/s41467-022-32229-9
Nature Communications 13(1), 4819 (2022). doi:10.1038/s41467-022-32229-9
Parkinson’s disease (PD) as a progressive neurodegenerative disorder arises from multiple genetic and environmental factors. However, underlying pathological mechanisms remain poorly understood. Using multiplexed single-cell transcriptomics, we ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbe9488b2ba42a49814c207703256ed
https://pubmed.ncbi.nlm.nih.gov/35974013
https://pubmed.ncbi.nlm.nih.gov/35974013
Autor:
Silke Lassmann, Jenny Ostendorp, Ulrich T. Hopt, Jens Hoeppner, Melanie Boerries, Theresa D. Ahrens, Marie Follo, Sina Hembach, Martin Werner, Hauke Busch, Sylvia Timme
Publikováno v:
Epigenetics. 10:431-445
Esophageal cancers are highly aggressive tumors with poor prognosis despite some recent advances in surgical and radiochemotherapy treatment options. This study addressed the feasibility of drugs targeting epigenetic modifiers in esophageal squamous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56655538ab8432406466cb56e162996a
https://doi.org/10.1080/15592294.2015.1039216
https://doi.org/10.1080/15592294.2015.1039216