Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sin Ho Kweon"'
Autor:
Xiaobo Mao, Hao Gu, Donghoon Kim, Yasuyoshi Kimura, Ning Wang, Enquan Xu, Ramhari Kumbhar, Xiaotian Ming, Haibo Wang, Chan Chen, Shengnan Zhang, Chunyu Jia, Yuqing Liu, Hetao Bian, Senthilkumar S. Karuppagounder, Fatih Akkentli, Qi Chen, Longgang Jia, Heehong Hwang, Su Hyun Lee, Xiyu Ke, Michael Chang, Amanda Li, Jun Yang, Cyrus Rastegar, Manjari Sriparna, Preston Ge, Saurav Brahmachari, Sangjune Kim, Shu Zhang, Yasushi Shimoda, Martina Saar, Haiqing Liu, Sin Ho Kweon, Mingyao Ying, Creg J. Workman, Dario A. A. Vignali, Ulrike C. Muller, Cong Liu, Han Seok Ko, Valina L. Dawson, Ted M. Dawson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/59a521d03e984273bb3d708b36d570e9
Autor:
Xiaobo Mao, Hao Gu, Donghoon Kim, Yasuyoshi Kimura, Ning Wang, Enquan Xu, Ramhari Kumbhar, Xiaotian Ming, Haibo Wang, Chan Chen, Shengnan Zhang, Chunyu Jia, Yuqing Liu, Hetao Bian, Senthilkumar S. Karuppagounder, Fatih Akkentli, Qi Chen, Longgang Jia, Heehong Hwang, Su Hyun Lee, Xiyu Ke, Michael Chang, Amanda Li, Jun Yang, Cyrus Rastegar, Manjari Sriparna, Preston Ge, Saurav Brahmachari, Sangjune Kim, Shu Zhang, Yasushi Shimoda, Martina Saar, Haiqing Liu, Sin Ho Kweon, Mingyao Ying, Creg J. Workman, Dario A. A. Vignali, Ulrike C. Muller, Cong Liu, Han Seok Ko, Valina L. Dawson, Ted M. Dawson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Pathologic α-synuclein (α-syn) spreads from cell-to-cell, in part, through binding to the lymphocyte-activation gene 3 (Lag3). Here we report that amyloid β precursor-like protein 1 (Aplp1) interacts with Lag3 that facilitates the binding
Externí odkaz:
https://doaj.org/article/a51c0a5470e944f6b5b546f3fa48e34f
Autor:
Saebom Lee, Hye Guk Ryu, Sin Ho Kweon, Hyerynn Kim, Hyeonwoo Park, Kyung-Ha Lee, Sang-Min Jang, Chan Hyun Na, Sangjune Kim, Han Seok Ko
Publikováno v:
Cells, Vol 11, Iss 24, p 3972 (2022)
Non-receptor tyrosine kinase, c-Abl plays a role in the pathogenesis of several neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. Here, we found that TDP-43, which was one of the main proteins comprising pathologica
Externí odkaz:
https://doaj.org/article/52a7d62560b54061891c5a0f3f91c34e
Autor:
Han Seok Ko, Yumin Oh, Wonjoong Richard Kim, Sangjune Kim, Saebom Lee, Changdev Gorakshnath Gadhe, Mi-Soon Kim, Jong-Sung Park, Bo Am Seo, Jae Eun Kim, Hyeongjun Kim, A Yeong Park, Seung-Hwan Kwon, Seulki Lee, Jinhwa Lee, Shi Xun Ma, Sin Ho Kweon, Suyeon Jo
Publikováno v:
Journal of Medicinal Chemistry. 64:15091-15110
Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects movement. The nonreceptor tyrosine kinase c-Abl has shown a potential role in the progression of PD. As such, c-Abl inhibition is a promising candidate for neuroprotect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69fdf73f6799461fd4da56ec23e9b72f
https://doi.org/10.1021/acs.jmedchem.1c01022
https://doi.org/10.1021/acs.jmedchem.1c01022
Publikováno v:
Genetics. 209:815-828
Post-translational control is a crucial mechanism for circadian timekeeping. Evolutionarily conserved kinases and phosphatases have been implicated in circadian phosphorylation and the degradation of clock-relevant proteins, which sustain high-amplit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd4037c22400dab38ef90157dfab180b
https://doi.org/10.1534/genetics.118.300808
https://doi.org/10.1534/genetics.118.300808
Autor:
Shi-Xun Ma, Changdev Gorakshnath Gadhe, Hyeongjun Kim, Suyeon Jo, Yumin Oh, Sin Ho Kweon, A Yeong Park, Saebom Lee, Jinhwa Lee, Seulki Lee, Han Seok Ko, Sangjune Kim, Wonjoong Richard Kim, Jong-Sung Park, Bo Am Seo, Jae Eun Kim, Mi-Soon Kim, Seung-Hwan Kwon
Publikováno v:
Journal of Medicinal Chemistry. 64:18237-18237
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4271ba84623203c014285a2d29a3c775
https://doi.org/10.1021/acs.jmedchem.1c01988
https://doi.org/10.1021/acs.jmedchem.1c01988
Autor:
Seung-Hwan Kwon, Sangjune Kim, A. Yeong Park, Saebom Lee, Gadhe, Changdev Gorakshnath, Bo Am Seo, Jong-Sung Park, Suyeon Jo, Yumin Oh, Sin Ho Kweon, Shi-Xun Ma, Kim, Wonjoong R., Misoon Kim, Hyeongjun Kim, Jae Eun Kim, Seulki Lee, Jinhwa Lee, Han Seok Ko
Publikováno v:
Journal of Medicinal Chemistry; 10/28/2021, Vol. 64 Issue 20, p15091-15110, 20p
Autor:
Seung-Hwan Kwon, Wei Yan, Min Seong Kim, Kwangsoo Kim, Senthilkumar S. Karuppagounder, Ted M. Dawson, Dong-Hoon Kim, Heehong Hwang, Sangjune Kim, Xiaobo Mao, Valina L. Dawson, Bo Am Seo, Je Min Yoo, Sang Ho Kwon, Seulah Choi, Sung Ung Kang, Javier Redding-Ochoa, Saebom Lee, Shi Xun Ma, Bong Gu Kang, Sin Ho Kweon, Olga Pletnikova, Tae In Kam, Juan C. Troncoso, Hu Wang, Hyejin Park, Gabsang Lee, Yong-Shi Li, Sheng-Han Kuo, Han Seok Ko
Publikováno v:
Neuron
Summary Impairment in glucocerebrosidase (GCase) is strongly associated with the development of Parkinson’s disease (PD), yet the regulators responsible for its impairment remain elusive. In this paper, we identify the E3 ligase Thyroid Hormone Rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9661bb275f9114b2d99f646e6aeb6cb7
https://pubmed.ncbi.nlm.nih.gov/34644545
https://pubmed.ncbi.nlm.nih.gov/34644545
Publikováno v:
Genetics. 209(3)
Post-translational control is a crucial mechanism for circadian timekeeping. Evolutionarily conserved kinases and phosphatases have been implicated in circadian phosphorylation and the degradation of clock-relevant proteins, which sustain high-amplit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::237b24e76e38ff64e4fd5d2bef0f2aaf
https://pubmed.ncbi.nlm.nih.gov/29724861
https://pubmed.ncbi.nlm.nih.gov/29724861
Publikováno v:
Archives of Pharmacal Research. 38:2020-2028
Sesquiterpene lactone compounds have received considerable attention in pharmacological research due to their therapeutic effects including anti-cancer and anti-inflammatory activities. In this report, we investigated the effect of arsantin, a sesqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b6890533ec92d087666d32b761b44c
https://doi.org/10.1007/s12272-015-0609-4
https://doi.org/10.1007/s12272-015-0609-4