Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sin Chi Chew"'
Autor:
Ah-Jung Jeon, Yue-Yang Teo, Karthik Sekar, Shay Lee Chong, Lingyan Wu, Sin-Chi Chew, Jianbin Chen, Raden Indah Kendarsari, Hannah Lai, Wen Huan Ling, Neslihan Arife Kaya, Jia Qi Lim, Adaikalavan Ramasamy, Gokce Oguz, Alexander Yaw-Fui Chung, Chung Yip Chan, Peng-Chung Cheow, Juinn Huar Kam, Krishnakumar Madhavan, Alfred Kow, Iyer Shridhar Ganpathi, Tony Kiat Hon Lim, Wei-Qiang Leow, Shihleone Loong, Tracy Jiezhen Loh, Wei Keat Wan, Gwyneth Shook Ting Soon, Yin Huei Pang, Boon Koon Yoong, Diana Bee-Lan Ong, Jasmine Lim, Vanessa H. de Villa, Rouchelle D.dela Cruz, Rawisak Chanwat, Jidapa Thammasiri, Glenn K. Bonney, Brian K. P. Goh, Greg Tucker-Kellogg, Roger Sik Yin Foo, Pierce K. H. Chow
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-16 (2023)
Abstract Background Conventional differential expression (DE) testing compares the grouped mean value of tumour samples to the grouped mean value of the normal samples, and may miss out dysregulated genes in small subgroup of patients. This is especi
Externí odkaz:
https://doaj.org/article/ac89eae58a5449229b3b4f7dcae89062
Autor:
Ah-Jung Jeon, Chukwuemeka George Anene-Nzelu, Yue-Yang Teo, Shay Lee Chong, Karthik Sekar, Lingyan Wu, Sin-Chi Chew, Jianbin Chen, Raden Indah Kendarsari, Hannah Lai, Wen Huan Ling, Neslihan Arife Kaya, Jia Qi Lim, Alexander Yaw Fui Chung, Peng-Chung Cheow, Juinn Huar Kam, Krishnakumar Madhavan, Alfred Kow, Iyer Shridhar Ganpathi, Tony Kiat Hon Lim, Wei-Qiang Leow, Shihleone Loong, Tracy Jiezhen Loh, Wei Keat Wan, Gwyneth Shook Ting Soon, Yin Huei Pang, Boon Koon Yoong, Diana Bee-Lan Ong, Jasmine Lim, Vanessa H. de Villa, Rouchelle D. dela Cruz, Rawisak Chanwat, Jidapa Thammasiri, Glenn K. Bonney, Brian K.P. Goh, Roger Sik Yin Foo, Pierce Kah-Hoe Chow
Publikováno v:
JHEP Reports, Vol 5, Iss 6, Pp 100715- (2023)
Background & Aims: Lifestyle and environmental-related exposures are important risk factors for hepatocellular carcinoma (HCC), suggesting that epigenetic dysregulation significantly underpins HCC. We profiled 30 surgically resected tumours and the m
Externí odkaz:
https://doaj.org/article/60b0d493517247318069a8fdb601a422
Autor:
Siming Ma, Lingyan Wu, Roger Foo, Han Chong Toh, Rouchelle D Dela Cruz, Wei Keat Wan, Alexander Y. F. Chung, Mei Mei Chang, Alfred Wei Chieh Kow, He-Chuan Yang, Jidapa Thammasiri, Chen Jianbin, Pierce K. H. Chow, Neslihan A. Kaya, Glenn Kunnath Bonney, Jacob Josiah Santiago Alvarez, Yin Huei Pang, Peng Chung Cheow, Vanessa H. de Villa, Rawisak Chanwat, Bingxin Lu, K.P. Chua, Tony Kiat-Hon Lim, Pauline Jieqi Chen, Diana Bee-Lan Ong, Brian K. P. Goh, Boon Koon Yoong, Valerie Chew, Wei Qiang Leow, Weiwei Zhai, Zeng Zeng, Wai Leong Tam, Sin Chi Chew, Anders Jacobsen Skanderup, Yock Young Dan, Hannah Lai, Chung Yip Chan, Tracy Loh, Krishnakumar Madhavan, Juinn Huar Kam, Jia Qi Lim, Ser Yee Lee, Shridhar Ganpathi Iyer
Publikováno v:
National science review. 9(3)
Intra-tumor heterogeneity (ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic (transcriptomic and immune) heterogeneity. Using one of the largest prospective s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e22070b517a21c609bb19fe18d53c7c
https://pubmed.ncbi.nlm.nih.gov/35382356
https://pubmed.ncbi.nlm.nih.gov/35382356
Publikováno v:
Br J Cancer
We found a shared immunosuppressive microenvironment between foetal liver and hepatocellular carcinoma (HCC) which includes the re-emergence of foetal-associated endothelial cells (PLVAP/VEGFR2) and foetal-like (FOLR2) tumour-associated macrophages i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64e056c05f37ca18fb4383e8c95acd7
https://pubmed.ncbi.nlm.nih.gov/33767421
https://pubmed.ncbi.nlm.nih.gov/33767421
Publikováno v:
Drug Metabolism and Pharmacokinetics. 28:169-176
Summary: Several nuclear receptors are being increasingly recognized for their role as master xenosensors. Among them, CAR-RXRα heterodimer, as encoded by NR1I3 and NR2B1, responds to the presence of drug compounds and regulates the transcription of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989742bc8830cb7e5f4270103c4d8f20
https://doi.org/10.2133/dmpk.dmpk-12-sc-060
https://doi.org/10.2133/dmpk.dmpk-12-sc-060
Autor:
Balram Chowbay, Xiangai Chen, Edmund J.D. Lee, Edwin Sandanaraj, Eng Huat Tan, Onkar Singh, Sin Chi Chew, Wan-Teck Lim
Publikováno v:
British Journal of Clinical Pharmacology. 73:606-618
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • SLCO1B3 is an influx transporter located at the hepatocyte basolateral membrane and it is involved in the uptake of a broad range of drug substrates including docetaxel. • The pharmacogenetics of SLCO1B3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bf3c39a19a0c67383351e19be9645d9
https://doi.org/10.1111/j.1365-2125.2011.04123.x
https://doi.org/10.1111/j.1365-2125.2011.04123.x
Autor:
Balram Chowbay, Onkar Singh, Eng Huat Tan, Wan-Teck Lim, Xiangai Chen, Rathi Devi Ramasamy, Tejal Kulkarni, Edmund J.D. Lee, Sin Chi Chew
Publikováno v:
Cancer Chemotherapy and Pharmacology. 67:1471-1478
This exploratory study aimed to explain the interindividual variabilities of docetaxel pharmacokinetics and pharmacodynamics in Asian nasopharyngeal carcinoma patients (n = 54) through the genotyping of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ad44368ffb400098c35d461b53870a
https://doi.org/10.1007/s00280-011-1625-9
https://doi.org/10.1007/s00280-011-1625-9
Autor:
Onkar Singh, Joanne Lim, Xiangai Chen, Edmund-J D Lee, Eng Huat Tan, Balram Chowbay, Sin Chi Chew
Publikováno v:
European journal of clinical pharmacology. 70(2)
This exploratory study was aimed at elucidating the pharmacogenetics of regulatory nuclear receptors (PXR, CAR, RXRα and HNF4α) and their implications on docetaxel pharmacokinetics and pharmacodynamics in local Chinese nasopharyngeal cancer patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1ecb33a78f5d023c433222d35d06b6
https://pubmed.ncbi.nlm.nih.gov/24193570
https://pubmed.ncbi.nlm.nih.gov/24193570
Publikováno v:
Drug metabolism and pharmacokinetics. 28(3)
HNF4α (encoded by gene NR2A1) is a dominant transcriptional regulator of various drug disposition genes. It forms a circuitry of molecular cross-talk with other nuclear receptors such as PXR and CAR to synergistically initiate transcription. This st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6fff7d68ee635e8c2463717cc92632
https://pubmed.ncbi.nlm.nih.gov/23268925
https://pubmed.ncbi.nlm.nih.gov/23268925
Publikováno v:
Advances in Microbial Ecology ISBN: 9781461421818
Asia is the world’s largest continent hosting approximately 60% of the world population. Asia is located in the eastern and northern hemispheres and is divided into five main regions – Central Asia, Eastern Asia, Northern Asia, South-eastern Asia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb65648f14e76e41b8db77e082112c1b
https://doi.org/10.1007/978-1-4614-2182-5_12
https://doi.org/10.1007/978-1-4614-2182-5_12
