Zobrazeno 1 - 10
of 232
pro vyhledávání: '"Sin‐Hyeog Im"'
Autor:
Ju A Shim, So Min Lee, Jin Woo Jeong, Hyori Kim, Woo Jae Son, Jun Hong Park, Parkyong Song, Sin-Hyeog Im, Sangsu Bae, Jung-Hyun Park, Yuna Jo, Changwan Hong
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Introduction Cytokines of the common γ chain (γc) family are critical for the development, differentiation, and survival of T lineage cells. Cytokines play key roles in immunodeficiencies, autoimmune diseases, allergies, and cancer. Althou
Externí odkaz:
https://doaj.org/article/baaa9c416720449ea76683b5ebbf1a39
Autor:
Heewon Cho, Haw-Young Kwon, Amit Sharma, Sun Hyeok Lee, Xiao Liu, Naoki Miyamoto, Jong-Jin Kim, Sin-Hyeog Im, Nam-Young Kang, Young-Tae Chang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
Studying the specific roles of macrophage subsets has been hampered by a lack of subset-specific probes. Here the authors report an M1 selective fluorescent probe named CDr17, and demonstrate the suitability of this probe for tracking M1 macrophages
Externí odkaz:
https://doaj.org/article/9d22797d096d44b6b006ce06f63551e8
Publikováno v:
EBioMedicine, Vol 94, Iss , Pp 104705- (2023)
Summary: Background: Poor translation between in vitro and clinical studies due to the cells/humans discrepancy in drug target perturbation effects leads to safety failures in clinical trials, thus increasing drug development costs and reducing patie
Externí odkaz:
https://doaj.org/article/f55c24d03c434bb698c113fbb935d57a
Publikováno v:
Lupus Science and Medicine, Vol 10, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/5c7fb4b355344305bed3e9b9dc414b41
Autor:
Sang-Hyeon Mun, Chang-Seok Lee, Hyun Jin Kim, Jiye Kim, Haena Lee, Jihye Yang, Sin-Hyeog Im, Joung-Hun Kim, Je Kyung Seong, Cheol-Sang Hwang
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112746- (2023)
Summary: The metabolic prohormone pro-opiomelanocortin (POMC) is generally translocated into the endoplasmic reticulum (ER) for entry into the secretory pathway. Patients with mutations within the signal peptide (SP) of POMC or its adjoining segment
Externí odkaz:
https://doaj.org/article/8035602214aa4ade9988152c84a915a0
Autor:
JungHo Kong, Doyeon Ha, Juhun Lee, Inhae Kim, Minhyuk Park, Sin-Hyeog Im, Kunyoo Shin, Sanguk Kim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Identifying biomarkers for response to immunotherapy in cancer remains challenging. Here, the authors develop an approach based on network biology and machine learning -NetBio- to identify molecular biomarkers of response to immunotherapy across diff
Externí odkaz:
https://doaj.org/article/1ca80e0d29034ebfa2843e0b952e9e78
Autor:
Dokyung Jung, Sanghee Shin, Sung‐Min Kang, Inseong Jung, Suyeon Ryu, Soojeong Noh, Sung‐Jin Choi, Jongwon Jeong, Beom Yong Lee, Kwang‐Soo Kim, Christine Seulki Kim, Jong Hyuk Yoon, Chan‐Hyeong Lee, Felicitas Bucher, Yong‐Nyun Kim, Sin‐Hyeog Im, Byoung‐Joon Song, Kyungmoo Yea, Moon‐Chang Baek
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 12, Pp n/a-n/a (2022)
Abstract T cell‐derived small extracellular vesicles (sEVs) exhibit anti‐cancer effects. However, their anti‐cancer potential should be reinforced to enhance clinical applicability. Herein, we generated interleukin‐2‐tethered sEVs (IL2‐sE
Externí odkaz:
https://doaj.org/article/50e0f0e66f9d4acd8f7796cac0e4289b
Autor:
Changhon Lee, Ravi Verma, Seohyun Byun, Eun-Ji Jeun, Gi-Cheon Kim, Suyoung Lee, Hye-Ji Kang, Chan Johng Kim, Garima Sharma, Abhishake Lahiri, Sandip Paul, Kwang Soon Kim, Dong Soo Hwang, Yoichiro Iwakura, Immacolata Speciale, Antonio Molinaro, Cristina De Castro, Dipayan Rudra, Sin-Hyeog Im
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Yeast form part of the host microbiome with known impact on host immunity. Here the authors identify and investigate the impact of commensal yeast-derived polysaccharides in modulating host inflammation, and show its potential for inhibiting inflamma
Externí odkaz:
https://doaj.org/article/8d8a0c93ffdc40c5895eee15da943473
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
E and inhibitor of DNA binding (ID) proteins are involved in various cellular developmental processes and effector activities in T cells. Recent findings indicate that E and ID proteins are not only responsible for regulating thymic T cell developmen
Externí odkaz:
https://doaj.org/article/ec9351f299624aceb15ffee91f2cc703
Autor:
Sun Mi Hong, A-Yeon Lee, Sung-Min Hwang, Yu-Jin Ha, Moo-Jin Kim, Seongki Min, Won Hwang, Gyesoon Yoon, So Mee Kwon, Hyun Goo Woo, Hee-Hoon Kim, Won-Il Jeong, Han-Ming Shen, Sin-Hyeog Im, Dakeun Lee, You-Sun Kim
Publikováno v:
Redox Biology, Vol 50, Iss , Pp 102237- (2022)
Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD+) salvage pathway and plays a crucial role in the maintenance of the NAD+ pool during inflammation. Considering that macrophages
Externí odkaz:
https://doaj.org/article/4f84bec6185c4c0ca0541ee759f35cbb