Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Sinéad M, Lougheed"'
Autor:
Tom van den Ende, Aiarpi Ezdoglian, Lisanne M. Baas, Joyce Bakker, Sinéad M. Lougheed, Micaela Harrasser, Cynthia Waasdorp, Mark I. van Berge Henegouwen, Maarten C.C.M. Hulshof, Nadia Haj Mohammad, Richard van Hillegersberg, Stella Mook, Conny J. van der Laken, Nicole C.T. van Grieken, Sarah Derks, Maarten F. Bijlsma, Hanneke W.M. van Laarhoven, Tanja D. de Gruijl
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTThe analysis of peripheral blood mononuclear cells (PBMCs) by flow cytometry holds promise as a platform for immune checkpoint inhibition (ICI) biomarker identification. Our aim was to characterize the systemic immune compartment in resectabl
Externí odkaz:
https://doaj.org/article/875b94688d2a4d92a00af551e8bbb88a
Autor:
Elisabetta Michielon, Marta López González, Dorian A. Stolk, Joeke G. C. Stolwijk, Sanne Roffel, Taco Waaijman, Sinéad M. Lougheed, Tanja D. de Gruijl, Susan Gibbs
Publikováno v:
Cancers, Vol 15, Iss 10, p 2849 (2023)
Invasion, immune modulation, and angiogenesis are crucial in melanoma progression. Studies based on animals or two-dimensional cultures poorly recapitulate the tumor-microenvironmental cross-talk found in humans. This highlights a need for more physi
Externí odkaz:
https://doaj.org/article/4b79d3dd689045b9a2c628928615c3c6
Autor:
Iris E Glykofridis, Jaco C Knol, Jesper A Balk, Denise Westland, Thang V Pham, Sander R Piersma, Sinéad M Lougheed, Sepide Derakhshan, Puck Veen, Martin A Rooimans, Saskia E van Mil, Franziska Böttger, Pino J Poddighe, Irma van de Beek, Jarno Drost, Fried JT Zwartkruis, Renee X de Menezes, Hanne EJ Meijers-Heijboer, Arjan C Houweling, Connie R Jimenez, Rob MF Wolthuis
Publikováno v:
eLife, Vol 10 (2021)
Germline mutations in the Folliculin (FLCN) tumor suppressor gene cause Birt–Hogg–Dubé (BHD) syndrome, a rare autosomal dominant disorder predisposing carriers to kidney tumors. FLCN is a conserved, essential gene linked to diverse cellular proc
Externí odkaz:
https://doaj.org/article/afeb46d1c35540eaa522d75e244c66bd
Autor:
Renée C. G. de Bruin, John P. Veluchamy, Sinéad M. Lougheed, Famke L. Schneiders, Silvia Lopez-Lastra, Roeland Lameris, Anita G. Stam, Zsolt Sebestyen, Jürgen Kuball, Carla F. M. Molthoff, Erik Hooijberg, Rob C. Roovers, James P. Di Santo, Paul M. P. van Bergen en Henegouwen, Henk M. W. Verheul, Tanja D. de Gruijl, Hans J. van der Vliet
Publikováno v:
OncoImmunology, Vol 7, Iss 1 (2018)
Though Vγ9Vδ2-T cells constitute only a small fraction of the total T cell population in human peripheral blood, they play a vital role in tumor defense and are therefore of major interest to explore for cancer immunotherapy. Vγ9Vδ2-T cell-based
Externí odkaz:
https://doaj.org/article/7c5a3a971c7f40ea88934267608977f3
Autor:
Kim M, van Pul, Jessica C L, Notohardjo, Marieke F, Fransen, Bas D, Koster, Anita G M, Stam, Dafni, Chondronasiou, Sinéad M, Lougheed, Joyce, Bakker, Vinitha, Kandiah, M Petrousjka, van den Tol, Karin, Jooss, Ronald J C L M, Vuylsteke, Alfons J M, van den Eertwegh, Tanja D, de Gruijl
Publikováno v:
Science immunology. 7(73)
Preclinical studies show that locoregional CTLA-4 blockade is equally effective in inducing tumor eradication as systemic delivery, without the added risk of immune-related side effects. This efficacy is related to access of the CTLA-4 blocking antib
Autor:
Sirinart Aromseree, Jaap M Middeldorp, Chamsai Pientong, Monique van Eijndhoven, Octavia Ramayanti, Sinéad M Lougheed, D Michiel Pegtel, Renske D M Steenbergen, Tipaya Ekalaksananan
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169290 (2017)
Different types of cells infected with Epstein-Barr virus (EBV) can release exosomes containing viral components that functionally affect neighboring cells. Previously, we found that EBV was localized mostly in infiltrating lymphocytes within the str
Externí odkaz:
https://doaj.org/article/6b27e0d3bc874363ac1717098b5a4f31
Autor:
A. Marijne Heeren, Ekaterina S. Jordanova, Constantijne H. Mom, Maaike C G Bleeker, Henry Zijlmans, Tanja D. de Gruijl, Sinéad M. Lougheed, Anita G.M. Stam, Noëlle Pocorni, Awa A Gassama, G.G. Kenter, Jossie Rotman
Publikováno v:
Clinical Cancer Research, 26(14), 3791-3802. American Association for Cancer Research Inc.
Rotman, J, Heeren, A M, Gassama, A A, Lougheed, S M, Pocorni, N, Stam, A G M, Bleeker, M C G, Zijlmans, H J M A A, Mom, C H, Kenter, G G, Jordanova, E S & de Gruijl, T D 2020, ' Adenocarcinoma of the Uterine Cervix Shows Impaired Recruitment of cDC1 and CD8 + T Cells and Elevated β-Catenin Activation Compared with Squamous Cell Carcinoma ', Clinical Cancer Research, vol. 26, no. 14, pp. 3791-3802 . https://doi.org/10.1158/1078-0432.CCR-19-3826
Clinical cancer research, 26(14), 3791-3802. American Association for Cancer Research Inc.
Rotman, J, Heeren, A M, Gassama, A A, Lougheed, S M, Pocorni, N, Stam, A G M, Bleeker, M C G, Zijlmans, H J M A A, Mom, C H, Kenter, G G, Jordanova, E S & de Gruijl, T D 2020, ' Adenocarcinoma of the Uterine Cervix Shows Impaired Recruitment of cDC1 and CD8 + T Cells and Elevated β-Catenin Activation Compared with Squamous Cell Carcinoma ', Clinical Cancer Research, vol. 26, no. 14, pp. 3791-3802 . https://doi.org/10.1158/1078-0432.CCR-19-3826
Clinical cancer research, 26(14), 3791-3802. American Association for Cancer Research Inc.
Purpose:Adenocarcinoma of the uterine cervix is the second most common type of cervical cancer after squamous cell carcinoma (SCC). Although both subtypes are treated similarly, patients with adenocarcinoma have a worse prognosis. In this study, immu
Autor:
Paul Hamberg, John B. A. G. Haanen, Hans van Vliet, Metin Tascilar, Zuhir Bodalal, Tanja D. de Gruijl, Carla M.L. van Herpen, Henk M.W. Verheul, Sinéad M. Lougheed, Charlotte M. Huijts
Publikováno v:
Huijts, C M, Lougheed, S M, Bodalal, Z, van Herpen, C M, Hamberg, P, Tascilar, M, Haanen, J B, Verheul, H M, de Gruijl, T D, van der Vliet, H J & Dutch WIN-O Consortium 2019, ' The effect of everolimus and low-dose cyclophosphamide on immune cell subsets in patients with metastatic renal cell carcinoma: results from a phase I clinical trial ', Cancer Immunology, Immunotherapy, vol. 68, no. 3, pp. 503-515 . https://doi.org/10.1007/s00262-018-2288-8
Cancer Immunology, Immunotherapy, 68(3), 503-515. Springer Science and Business Media Deutschland GmbH
Cancer Immunology, Immunotherapy
Cancer Immunology Immunotherapy, 68, 503-515
Cancer Immunology Immunotherapy, 68, 3, pp. 503-515
Cancer Immunology, Immunotherapy, 68(3), 503-515. Springer Science and Business Media Deutschland GmbH
Cancer Immunology, Immunotherapy
Cancer Immunology Immunotherapy, 68, 503-515
Cancer Immunology Immunotherapy, 68, 3, pp. 503-515
For the treatment of metastatic renal cell cancer several strategies are used among which the mTOR inhibitor everolimus. As mTOR plays an important role in the immune system, e.g., by controlling the expression of the transcription factor FoxP3 there
Autor:
Sepide Derakhshan, Saskia E. van Mil, Arjan C. Houweling, Puck Veen, Irma van de Beek, Iris E. Glykofridis, Jaco C. Knol, Jesper A. Balk, Rob M. F. Wolthuis, Thang V. Pham, Martin A. Rooimans, Pino J Poddighe, Jarno Drost, Franziska Böttger, Sander R. Piersma, Fried J. T. Zwartkruis, Denise Westland, Sinéad M. Lougheed, Hanne Meijers-Heijboer, Renee X. de Menezes, Connie R. Jimenez
Publikováno v:
eLife, Vol 10 (2021)
Glykofridis, I E, Knol, J C, Balk, J A, Westland, D, Pham, T V, Piersma, S R, Lougheed, S M, Derakhshan, S, Veen, P, Rooimans, M A, van Mil, S E, Böttger, F, Poddighe, P J, van de Beek, I, Drost, J, Zwartkruis, F J T, de Menezes, R X, Meijers-Heijboer, H E J, Houweling, A C, Jimenez, C R & Wolthuis, R M F 2021, ' Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells ', eLife, vol. 10, e61630, pp. 1-71 . https://doi.org/10.7554/eLife.61630
eLife, 10:e61630, 1-71. eLife Sciences Publications Limited
eLife
eLife, 10:e61630, 1-71. eLife Sciences Publications
Glykofridis, I E, Knol, J C, Balk, J A, Westland, D, Pham, T V, Piersma, S R, Lougheed, S M, Derakhshan, S, Veen, P, Rooimans, M A, van Mil, S E, Böttger, F, Poddighe, P J, van de Beek, I, Drost, J, Zwartkruis, F J T, de Menezes, R X, Meijers-Heijboer, H E J, Houweling, A C, Jimenez, C R & Wolthuis, R M F 2021, ' Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells ', eLife, vol. 10, e61630, pp. 1-71 . https://doi.org/10.7554/eLife.61630
eLife, 10:e61630, 1-71. eLife Sciences Publications Limited
eLife
eLife, 10:e61630, 1-71. eLife Sciences Publications
Germline mutations in the Folliculin (FLCN) tumor suppressor gene cause Birt–Hogg–Dubé (BHD) syndrome, a rare autosomal dominant disorder predisposing carriers to kidney tumors.FLCNis a conserved, essential gene linked to diverse cellular proces
Autor:
Tanja D. de Gruijl, Kim M. van Pul, Ronald J.C.L.M. Vuylsteke, Petrousjka van den Tol, Alfons J.M. van den Eertwegh, Dafni Chondronasiou, Karin Ute Jooss, Jessica Notohardjo, Sinéad M. Lougheed, Anita G.M. Stam
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background The sentinel lymph node (SLN) is the first node to receive lymphatic drainage from the primary tumor and the site where naive T cells are first primed. As such it is of great importance in initiating an effective anti-tumor immune response