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Genetic deletion of skeletal muscle iPLA 2 γ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolism.

Autor: Moon SH; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., Dilthey BG; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., Guan S; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., Sims HF; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., Pittman SK; Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Keith AL; Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Jenkins CM; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., Weihl CC; Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Gross RW; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.; Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA.; Center for Cardiovascular Research, Washington University School of Medicine, Saint Louis, MO 63110, USA.; Department of Chemistry, Washington University, Saint Louis, MO 63130, USA.

Publikováno v: IScience [iScience] 2023 May 18; Vol. 26 (6), pp. 106895. Date of Electronic Publication: 2023 May 18 (Print Publication: 2023).

A functional role for eicosanoid-lysophospholipids in activating monocyte signaling.

Autor: Liu GY; Department of Chemistry, Washington University, Saint Louis, Missouri, USA; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA., Moon SH; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA., Jenkins CM; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA., Sims HF; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA., Guan S; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA., Gross RW; Department of Chemistry, Washington University, Saint Louis, Missouri, USA; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA; Developmental Biology, Washington University School of Medicine, Saint Louis, Missouri, USA; Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA. Electronic address: rgross@wustl.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2020 Aug 21; Vol. 295 (34), pp. 12167-12180. Date of Electronic Publication: 2020 Jul 08.

Genetic deletion of calcium-independent phospholipase A2γ protects mice from diabetic nephropathy.

Autor: Cybulsky, Andrey V.¹ (AUTHOR) andrey.cybulsky@mcgill.ca, Papillon, Joan¹ (AUTHOR), Guillemette, Julie¹ (AUTHOR), Navarro-Betancourt, José R.¹ (AUTHOR), Elimam, Hanan² (AUTHOR), Fantus, I. George¹ (AUTHOR)

Publikováno v: PLoS ONE. 10/31/2024, Vol. 19 Issue 10, p1-21. 21p.

The phospholipase iPLA 2 γ is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling.

Autor: Liu GY; From the Department of Chemistry, Washington University, Saint Louis, Missouri 63130 and., Moon SH; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine., Jenkins CM; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine., Li M; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine., Sims HF; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine., Guan S; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine., Gross RW; From the Department of Chemistry, Washington University, Saint Louis, Missouri 63130 and rgross@wustl.edu.; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine.; Department of Developmental Biology, and.; Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2017 Jun 23; Vol. 292 (25), pp. 10672-10684. Date of Electronic Publication: 2017 Apr 25.