Identification and characterisation of functional Kir6.1‐containing ATP‐sensitive potassium channels in the cardiac ventricular sarcolemmal membrane.

Autor: Brennan, Sean, Chen, Shen, Makwana, Samir, Esposito, Simona, McGuinness, Lauren R., Alnaimi, Abrar I. M., Sims, Mark W., Patel, Manish, Aziz, Qadeer, Ojake, Leona, Roberts, James A., Sharma, Parveen, Lodwick, David, Tinker, Andrew, Barrett‐Jolley, Richard, Dart, Caroline, Rainbow, Richard D.

Publikováno v: British Journal of Pharmacology; Sep2024, Vol. 181 Issue 18, p3380-3400, 21p

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Distinct and complementary roles for α and β isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose

Autor: Jackson, Robert, Brennan, Sean, Fielding, Peter, Sims, Mark W, Challiss, RA John, Adlam, David, Squire, Iain B, Rainbow, Richard D

We investigated the hypothesis that elevated glucose increases contractile responses in vascular smooth muscle and that this enhanced constriction occurs due to the glucose-induced PKC-dependent inhibition of voltage-gated potassium channels.Patch-cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e54570dc97638c7954088b50cea15929
https://europepmc.org/articles/PMC4761094/

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Identification and characterisation of functional K ir 6.1-containing ATP-sensitive potassium channels in the cardiac ventricular sarcolemmal membrane.

Autor: Brennan S; Department of Cardiovascular and Metabolic Medicine and Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK., Chen S; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., Makwana S; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., Esposito S; Department of Cardiovascular and Metabolic Medicine and Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK.; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., McGuinness LR; Department of Cardiovascular and Metabolic Medicine and Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK., Alnaimi AIM; Department of Cardiovascular and Metabolic Medicine and Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK.; Department of Cardiac Technology, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Sims MW; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., Patel M; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., Aziz Q; William Harvey Research Institute, Queen Mary University of London, London, UK., Ojake L; William Harvey Research Institute, Queen Mary University of London, London, UK., Roberts JA; Department of Cardiovascular and Metabolic Medicine and Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK., Sharma P; Department of Cardiovascular and Metabolic Medicine and Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK., Lodwick D; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., Tinker A; William Harvey Research Institute, Queen Mary University of London, London, UK., Barrett-Jolley R; Department of Musculoskeletal and Ageing Science, University of Liverpool, Liverpool, UK., Dart C; Department of Biochemistry, Cell and Systems Biology, University of Liverpool, Liverpool, UK., Rainbow RD; Department of Cardiovascular and Metabolic Medicine and Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 Sep; Vol. 181 (18), pp. 3380-3400. Date of Electronic Publication: 2024 May 19.