Integrated DNA and RNA Sequencing Reveals Drivers of Endocrine Resistance in Estrogen Receptor–Positive Breast Cancer

Autor: Xia, Youli, He, Xiaping, Renshaw, Lorna, Sims, Andrew H, Martinez-Perez, Carlos, Kay, Charlene, Gray, Mark, Meehan, James, S Parker, Joel, M. Perou, Charles, A. Carey, Lisa, Dixon, MIchael, Turnbull, Arran K

Publikováno v: Xia, Y, He, X, Renshaw, L, Sims, A H, Martinez-Perez, C, Kay, C, Gray, M, Meehan, J, S Parker, J, M. Perou, C, A. Carey, L, Dixon, MI & Turnbull, A K 2022, ' Integrated DNA and RNA Sequencing Reveals Drivers of Endocrine Resistance in Estrogen Receptor Positive Breast Cancer ', Clinical Cancer Research . https://doi.org/10.1158/1078-0432.CCR-21-3189

Purpose: Endocrine therapy resistance (ETR) remains the greatest challenge in treating patients with hormone receptor–positive breast cancer. We set out to identify molecular mechanisms underlying ETR through in-depth genomic analysis of breast tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c21d29d4f553994518a3acc18022f8
https://doi.org/10.1158/1078-0432.ccr-21-3189

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Toll-like receptor orchestrates a tumor suppressor response in non-small cell lung cancer

Autor: Millar, Fraser, Pennycuick, Adam, Muir, Morwenna, Quintanilla, Andrea, Hari, Priya, Freyer, Elisabeth, Gautier, Philippe, Meynert, Alison M, Grimes, Graeme R, Salomo Coll, Carla, Zdral, Sofia, Victorelli, Stella, Teixeira, Vitor H., Connolly, John, Passos, Joao F, Ros, Marian A, Wallace, William, Frame, Margaret C, Sims, Andrew H, Boulter, Luke, Janes, Sam M, Wilkinson, Simon, Acosta, Juan Carlos

Publikováno v: Millar, F, Pennycuick, A, Muir, M, Quintanilla, A, Hari, P, Freyer, E, Gautier, P, Meynert, A M, Grimes, G R, Salomo Coll, C, Zdral, S, Victorelli, S, Teixeira, V H, Connolly, J, Passos, J F, Ros, M A, Wallace, W, Frame, M C, Sims, A H, Boulter, L, Janes, S M, Wilkinson, S & Acosta, J C 2022, ' Toll-like receptor orchestrates a tumor suppressor response in non-small cell lung cancer ', Cell Reports . https://doi.org/10.1016/j.celrep.2022.111596

Targeting early-stage lung cancer is vital to improve survival. Yet, the mechanisms and components of the early tumor suppressor response in lung cancer are not well understood. In this report we study the role of TLR2, a regulator of oncogene-induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::258cd64b70b9116c67b233424ea571ce
https://www.pure.ed.ac.uk/ws/files/308129435/Toll_like_receptor_orchestrates_a_tumor_suppressor_response_in_non_small_cell_lung_cancer_published_pdf.pdf

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Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer

Autor: Sproul, Duncan, Nestor, Colm, Culley, Jayne, Dickson, Jacqueline H., Dixon, J. Michael, Harrison, David J., Meehan, Richard R., Sims, Andrew H., Ramsahoye, Bernard H., Jaenisch, Rudolf

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2011 Mar . 108(11), 4364-4369.

Externí odkaz: https://www.jstor.org/stable/41061120