Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Simret Beraki"'
Autor:
Mir Hashim, Radhika Korupolu, Baber Syed, Kyle Horlen, Simret Beraki, Padma Karamchedu, Arvinder K. Dhalla, Rodolphe Ruffy, Mir Imran
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 5, Pp n/a-n/a (2019)
Abstract Biotherapeutic agents must be administered parenterally to obtain therapeutic blood concentrations, lowering patient compliance and complicating care. An oral delivery platform (ODP) was developed to deliver drugs into the small intestinal w
Externí odkaz:
https://doaj.org/article/033713911bad42d1bf9fd27695db919f
Autor:
Simret Beraki, Lily Litrus, Liza Soriano, Marie Monbureau, Lillian K To, Steven P Braithwaite, Karoly Nikolich, Roman Urfer, Donna Oksenberg, Mehrdad Shamloo
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69233 (2013)
With the availability and ease of small molecule production and design continuing to improve, robust, high-throughput methods for screening are increasingly necessary to find pharmacologically relevant compounds amongst the masses of potential candid
Externí odkaz:
https://doaj.org/article/2585762e94f04539b33efdaba5ffad9b
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46604 (2012)
Npas4 is a transcription factor, which is highly expressed in the brain and regulates the formation and maintenance of inhibitory synapses in response to excitatory synaptic activity. A deregulation of the inhibitory-excitatory balance has been assoc
Externí odkaz:
https://doaj.org/article/d7235d8168ca4fd9950d9e9a07f8539e
Autor:
Jenny U Johansson, Jesper Ericsson, Juliette Janson, Simret Beraki, Davor Stanić, Slavena A Mandic, Martin A Wikström, Tomas Hökfelt, Sven Ove Ogren, Björn Rozell, Per-Olof Berggren, Christina Bark
Publikováno v:
PLoS Genetics, Vol 4, Iss 11, p e1000278 (2008)
Alternative splicing is an evolutionary innovation to create functionally diverse proteins from a limited number of genes. SNAP-25 plays a central role in neuroexocytosis by bridging synaptic vesicles to the plasma membrane during regulated exocytosi
Externí odkaz:
https://doaj.org/article/2c86a0d4010148f5a31eb107bae68898
Autor:
Laura Fusaro, Baber Syed, Shilpy Sharma, Radhika Korupolu, Anvesh Dasari, Betsy Gutierrez, Radia Abdul-Wahab, Padma Karamchedu, Mir Hashim, Delia Gratta, Shane Yen, April T Vo, Mir A. Imran, Anusha Garapaty, Simret Beraki, Asad Wasi, Mansoor Syed, Arvinder K. Dhalla, Kyle Horlen, Zachary Owyang, Alyson Yamaguchi, Chang Ong, Vasudha Salgotra, Leonard C Fung, Eric Liang, Ziad T. Al-Shamsie
Publikováno v:
Drug Delivery and Translational Research
Biotherapeutics are highly efficacious, but the pain and inconvenience of chronic injections lead to poor patient compliance and compromise effective disease management. Despite innumerable attempts, oral delivery of biotherapeutics remains unsuccess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21c1e00d310317beccfb90e3139f477
https://doi.org/10.1007/s13346-021-00938-1
https://doi.org/10.1007/s13346-021-00938-1
Autor:
Radhika Korupolu, Mir A. Imran, Baber Syed, Mir Hashim, Simret Beraki, Kyle Horlen, Padma Karamchedu, Rodolphe Ruffy, Arvinder K. Dhalla
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 5, Pp n/a-n/a (2019)
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives
Biotherapeutic agents must be administered parenterally to obtain therapeutic blood concentrations, lowering patient compliance and complicating care. An oral delivery platform (ODP) was developed to deliver drugs into the small intestinal wall. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad965775b29f5e84d6124b8f60e6b9c7
https://doaj.org/article/033713911bad42d1bf9fd27695db919f
https://doaj.org/article/033713911bad42d1bf9fd27695db919f
Autor:
Ziad T. Al-Shamsie, Padma Karamchedu, Anvesh Dasari, Arvinder K. Dhalla, Laura Fusaro, Delia Gratta, Eric Liang, Rodolphe Ruffy, Baber Syed, Anusha Garapaty, April Toledo, Radhika Korupolu, Mir Hashim, Shilpy Sharma, Leonard C Fung, Simret Beraki, Mir A. Imran, Radia Abdul Wahab, Alyson Yamaguchi, Vasudha Salgotra
Publikováno v:
Diabetes. 68
Aim: We developed a platform to painlessly deliver by mouth drugs that cannot be administered orally. This ingestible, capsule-like device deploys inside the small intestine and injects into its wall a biotherapeutic payload sealed inside a dissolvab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5bcf627a7744460f811dfaa1b220ec2
https://doi.org/10.2337/db19-125-lb
https://doi.org/10.2337/db19-125-lb
Autor:
Radhika Korupolu, Mir A. Imran, Padma Karamchedu, Baber Syed, Kyle Horlen, Simret Beraki, Arvinder K. Dhalla, Mir Hashim, Rodolphe Ruffy
Publikováno v:
Journal of the Endocrine Society
BACKGROUND: Biotherapeutic agents must be administered parenterally to reach and maintain therapeutic blood concentrations, lowering patient compliance and complicating long-term care. We have developed an ingestible robotic pill capable of deliverin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36eec8381b4e6da8783e1575b42cbae
http://europepmc.org/articles/PMC6552267
http://europepmc.org/articles/PMC6552267
Autor:
Mehrdad Faizi, Simret Beraki, Tony Wyss-Coray, Nay Saw, Mehrdad Shamloo, Thuy-Vi V. Nguyen, Patrick Bader, Frank M. Longo
Publikováno v:
Brain and Behavior
Alzheimer's disease (AD), the most common form of dementia, is an age-dependent progressive neurodegenerative disorder. β-amyloid, a metabolic product of the amyloid precursor protein (APP), plays an important role in the pathogenesis of AD. The Thy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5a6aad1014935b03dc7a087e842833
http://europepmc.org/articles/PMC3345358
http://europepmc.org/articles/PMC3345358
Publikováno v:
Brain, Behavior, and Immunity. 23:733-741
Epidemiological studies suggest that early life infections may contribute to the development of psychiatric disorders characterized by cognitive deficits. Here, we studied the effects of a neonatal influenza A/WSN/33 virus infection on locomotor acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe5dbe0dad198960b358f01759fad33
https://doi.org/10.1016/j.bbi.2009.04.004
https://doi.org/10.1016/j.bbi.2009.04.004