Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Simran Khurana"'
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT The life cycle of human papillomavirus (HPV) depends on keratinocyte differentiation as the virus modulates and takes advantage of cellular pathways to replicate its genome and assemble viral particles in differentiated cells. Viral genomes
Externí odkaz:
https://doaj.org/article/f31a631ba8ce4648b8bacf7d8c4ae011
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Human Papillomaviruses (HPV) reproduce in stratified epithelia by establishing a reservoir of low- level infection in the dividing basal cells and restricting the production of viral particles to terminally differentiated cells. These small DNA virus
Externí odkaz:
https://doaj.org/article/420d9ea06fcd45279af408839fe69b96
Publikováno v:
Viruses, Vol 13, Iss 2, p 321 (2021)
Persistent infection with oncogenic human papillomavirus (HPV) types is responsible for ~5% of human cancers. The HPV infectious cycle can sustain long-term infection in stratified epithelia because viral DNA is maintained as low copy number extrachr
Externí odkaz:
https://doaj.org/article/c917b409c2a5438db5a87d3219d084e1
The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)
The macroH2A1.2 histone variant facilitates the response to replication stress with implications for genome maintenance and cell growth. A mutually exclusive splice variant, macroH2A1.1, has opposing effects on DNA repair outcome and proliferation. H
Externí odkaz:
https://doaj.org/article/8c6ad2dc00cf4cda8825e69802fc152e
Autor:
Simran Khurana, Philipp Oberdoerffer
Publikováno v:
Genes, Vol 6, Iss 3, Pp 858-877 (2015)
DNA replication is essential for cell division. Challenges to the progression of DNA polymerase can result in replication stress, promoting the stalling and ultimately collapse of replication forks. The latter involves the formation of DNA double-str
Externí odkaz:
https://doaj.org/article/744695c05f6c4b79b48027e976f513f5
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006660 (2017)
We have shown previously that Sp100 (a component of the ND10 nuclear body) represses transcription, replication and establishment of incoming human papillomavirus (HPV) DNA in the early stages of infection. In this follow up study, we show that Sp100
Externí odkaz:
https://doaj.org/article/00daadd512f7485a81a4b2a5601b0d4e
Autor:
Simran Khurana, Michael J. Kruhlak, Jeongkyu Kim, Andy D. Tran, Jinping Liu, Katherine Nyswaner, Lei Shi, Parthav Jailwala, Myong-Hee Sung, Ofir Hakim, Philipp Oberdoerffer
Publikováno v:
Cell Reports, Vol 8, Iss 4, Pp 1049-1062 (2014)
Appropriate DNA double-strand break (DSB) repair factor choice is essential for ensuring accurate repair outcome and genomic integrity. The factors that regulate this process remain poorly understood. Here, we identify two repressive chromatin compon
Externí odkaz:
https://doaj.org/article/bcbd40e8c18048598eca34e3d1b5e693
Publikováno v:
PLoS ONE, Vol 8, Iss 6 (2013)
Externí odkaz:
https://doaj.org/article/a05cd5a9248448628d148b2f1fdb8f23
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60213 (2013)
Glomerular podocytes are highly differentiated epithelial cells that are key components of the kidney filtration units. Podocyte damage or loss is the hallmark of nephritic diseases characterized by severe proteinuria. Recent studies implicate that h
Externí odkaz:
https://doaj.org/article/10cd667f52004af8b8714ad3a2f850c7
The life cycle of HPV depends on keratinocyte differentiation as the virus modulates and takes advantage of cellular pathways to replicate its genome and assemble viral particles in differentiated cells. Viral genomes are amplified in nuclear replica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfb0b313e848bb7f5790a2e8451f49d7
https://doi.org/10.1101/2021.07.27.453825
https://doi.org/10.1101/2021.07.27.453825