The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

Autor: Gibbs, Julie E., Blaikley, John, Beesley, Stephen, Matthews, Laura, Simpson, Karen D., Boyce, Susan H., Farrow, Stuart N., Else, Kathryn J., Singh, Dave, Ray, David W., Loudon, Andrew S. I.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2012 Jan 01. 109(2), 582-587.

Externí odkaz: https://www.jstor.org/stable/23076015

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A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function

Autor: Matthews, Laura, Trebble, Peter J., Woolven, James M., Saunders, Ken A., Simpson, Karen D., Farrow, Stuart N., Matthews, Laura C., Ray, David W.

Publikováno v: Matthews, L, Trebble, P J, Woolven, J M, Saunders, K A, Simpson, K D, Farrow, S N, Matthews, L C & Ray, D W 2013, ' A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function ', Journal of Cell Science, vol. 126, no. 14, pp. 3159-3169 . https://doi.org/10.1242/jcs.124784

The ubiquitously expressed glucocorticoid receptor (GR) is a major drug target for inflammatory disease, but issues of specificity and target tissue sensitivity remain. We now identify high potency, non-steroidal GR ligands, GSK47867A and GSK47869A,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe5b61d00f0a9e0d28eb6accc3fab9b
http://jcs.biologists.org/content/126/14/3159.full.pdf

Ampicillin resistance in Haemophilus influenzae from COPD patients in the UK.

Autor: Maddi, Satyanarayana, Kolsum, Umme, Jackson, Sarah, Barraclough, Richard, Maschera, Barbara, Simpson, Karen D., Pascal, Thierry G., Durviaux, Serge, Hessel, Edith M., Singh, Dave

Publikováno v: International Journal of COPD; May2017, Vol. 12, p1507-1518, 12p

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