Preclinical development of lyophilized self-replicating RNA vaccines for COVID-19 and malaria with improved long-term thermostability

Autor: Gulati, Gaurav K., Simpson, Adrian C., MacMillen, Zachary, Krieger, Kyle, Sharma, Shibbu, Erasmus, Jesse H., Reed, Steven G., Davie, James W., Avril, Marion, Khandhar, Amit P.

Publikováno v: In Journal of Controlled Release 10 January 2025 377:81-92

Physicochemical structure of a polyacrylic acid stabilized nanoparticle alum (nanoalum) adjuvant governs TH1 differentiation of CD4+ T cells

Autor: Khandhar, Amit P., Liang, Hong, Simpson, Adrian C., Reed, Steven G., Carter, Darrick, Fox, Christopher B., Orr, Mark T.

This is the accepted manuscript version of the work published in its final form as Khandhar., P., A., Liang., Hong., Simpson., C., A., Reed., G., S., Carter., Darrick., Fox., B., C., Orr., & T., M. (2020). Physicochemical structure of a polyacrylic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f784e54ece71b7c93946ecae2f54d7

Preclinical development of lyophilized self-replicating RNA vaccines for COVID-19 and malaria with improved long-term thermostability.

Autor: Gulati GK; HDT Bio, 1150 Eastlake Ave E Suite 200A, Seattle, WA 98109, USA. Electronic address: gaurav.gulati@hdt.bio., Simpson AC; HDT Bio, 1150 Eastlake Ave E Suite 200A, Seattle, WA 98109, USA., MacMillen Z; MalarVx, Inc, 1551 Eastlake Ave E, Suite 100, Seattle, WA 98102, USA., Krieger K; HDT Bio, 1150 Eastlake Ave E Suite 200A, Seattle, WA 98109, USA., Sharma S; HDT Bio, 1150 Eastlake Ave E Suite 200A, Seattle, WA 98109, USA., Erasmus JH; HDT Bio, 1150 Eastlake Ave E Suite 200A, Seattle, WA 98109, USA., Reed SG; HDT Bio, 1150 Eastlake Ave E Suite 200A, Seattle, WA 98109, USA., Davie JW; MalarVx, Inc, 1551 Eastlake Ave E, Suite 100, Seattle, WA 98102, USA., Avril M; MalarVx, Inc, 1551 Eastlake Ave E, Suite 100, Seattle, WA 98102, USA., Khandhar AP; HDT Bio, 1150 Eastlake Ave E Suite 200A, Seattle, WA 98109, USA. Electronic address: amit.khandhar@hdt.bio.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2024 Nov 17; Vol. 377, pp. 81-92. Date of Electronic Publication: 2024 Nov 17.