Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Simote Totauhelotu Foliaki"'
Autor:
Simote Totauhelotu Foliaki, Victoria Lewis, Abu Mohammed Taufiqual Islam, Laura Jane Ellett, Matteo Senesi, David Isaac Finkelstein, Blaine Roberts, Victoria A Lawson, Paul Anthony Adlard, Steven John Collins
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007712 (2019)
Although considerable evidence supports that misfolded prion protein (PrPSc) is the principal component of "prions", underpinning both transmissibility and neurotoxicity, clear consensus around a number of fundamental aspects of pathogenesis has not
Externí odkaz:
https://doaj.org/article/680806a49af640c999e500a3e009b326
Autor:
Simote Totauhelotu Foliaki, Victoria Lewis, David Isaac Finkelstein, Victoria Lawson, Harold Arthur Coleman, Matteo Senesi, Abu Mohammed Taufiqual Islam, Feng Chen, Shannon Sarros, Blaine Roberts, Paul Anthony Adlard, Steven John Collins
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007214 (2018)
Although misfolding of normal prion protein (PrPC) into abnormal conformers (PrPSc) is critical for prion disease pathogenesis our current understanding of the underlying molecular pathophysiology is rudimentary. Exploiting an electrophysiology parad
Externí odkaz:
https://doaj.org/article/711678d966744eccba3dfa4eaf8d1291
Autor:
Feng Chen, Ambili Thoppuvalappil Appukuttan, Paul A. Adlard, Ashley I. Bush, Scott Ayton, Peng Lei, Thibault Renoir, Anthony J. Hannan, Simote Totauhelotu Foliaki
Publikováno v:
Neurotherapeutics
There is currently no disease-modifying treatment for Huntington’s disease (HD), which is characterized by chorea motor impairment and cognitive decline. The zinc ionophore, PBT2, was previously shown to improve the phenotype of a HD mouse model an
Autor:
David Finkelstein, Simote Totauhelotu Foliaki, Matteo Senesi, Blaine R. Roberts, Steven J. Collins, Abu Mohammed Taufiqual Islam, Laura J Ellett, Victoria Lewis, Victoria A. Lawson, Paul A. Adlard
Publikováno v:
Biophys J
Prion diseases are neurodegenerative disorders pathogenically linked to cellular prion protein (PrPC) misfolding into abnormal conformers (PrPSc), with PrPSc underpinning both transmission and synaptotoxicity. Although the biophysical features of PrP
Autor:
Laura J Ellett, Steven J. Collins, Matteo Senesi, David Finkelstein, Blaine R. Roberts, Simote Totauhelotu Foliaki, Paul A. Adlard, Abu Mohammed Taufiqual Islam, Victoria Lewis, Victoria A. Lawson
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007712 (2019)
PLoS Pathogens
PLoS Pathogens
Although considerable evidence supports that misfolded prion protein (PrPSc) is the principal component of “prions”, underpinning both transmissibility and neurotoxicity, clear consensus around a number of fundamental aspects of pathogenesis has
Autor:
Richard J. Lobb, Jamie R. Kutasovic, Caroline Atkinson, Simote Totauhelotu Foliaki, Adrian P. Wiegmans, Colleen Niland, Andrew J. Dalley, Sunyoung Ham, Andreas Möller, Sunil R. Lakhani, Kaltin Ferguson, Jodi M. Saunus, Mariska Miranda, Steven J. Collins, Fares Al-Ejeh, Cameron N. Johnstone, Victoria Lewis
Publikováno v:
JCI insight. 5
Anthracyclines are amongst the most effective chemotherapeutics ever developed, but they produce grueling side-effects, serious adverse events and resistance often develops over time. We found that these compounds can be sequestered by secreted cellu
Autor:
David Finkelstein, Feng Chen, Victoria A. Lawson, Shannon Sarros, Simote Totauhelotu Foliaki, Harold A. Coleman, Abu Mohammed Taufiqual Islam, Matteo Senesi, Paul A. Adlard, Victoria Lewis, Blaine R. Roberts, Steven J. Collins
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 14, Iss 8, p e1007214 (2018)
PLoS Pathogens, Vol 14, Iss 8, p e1007214 (2018)
Although misfolding of normal prion protein (PrPC) into abnormal conformers (PrPSc) is critical for prion disease pathogenesis our current understanding of the underlying molecular pathophysiology is rudimentary. Exploiting an electrophysiology parad