Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Simote T. Foliaki"'
Autor:
Katie Williams, Simote T. Foliaki, Brent Race, Anna Smith, Tina Thomas, Bradley R. Groveman, Cathryn L. Haigh
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Background Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is a fatal neurodegenerative disease with currently no treatment options. Stem cell therapy for neurodegenerative diseases is emerging as a possible t
Externí odkaz:
https://doaj.org/article/76650160d49145ef9e878b0184a93c70
Autor:
Simote T. Foliaki, Cathryn L. Haigh
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/73f29b2e4d2f4febb896d5b062317cca
Autor:
Bradley R. Groveman, Brent Race, Simote T. Foliaki, Katie Williams, Andrew G. Hughson, Chase Baune, Gianluigi Zanusso, Cathryn L. Haigh
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Human cerebral organoids (COs) are three-dimensional self-organizing cultures of cerebral brain tissue differentiated from induced pluripotent stem cells. We have recently shown that COs are susceptible to infection with different subtypes o
Externí odkaz:
https://doaj.org/article/3c5bd4382a434ac5b0e23d8a75101206
Autor:
Aleksandar R. Wood, Simote T. Foliaki, Bradley R. Groveman, Ryan O. Walters, Katie Williams, Jue Yuan, Wen-Quan Zou, Cathryn L. Haigh
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Cardiomyopathy is a co-morbidity of some prion diseases including genetic disease caused by mutations within the PrP gene (PRNP). Although the cellular prion protein (PrP) has been shown to protect against cardiotoxicity caused by oxidative
Externí odkaz:
https://doaj.org/article/882680c5df1d458ba3fb9ad953652c19
Autor:
Simote T. Foliaki, Aleksandar Wood, Katie Williams, Anna Smith, Ryan O. Walters, Chase Baune, Bradley R. Groveman, Cathryn L. Haigh
Publikováno v:
Redox Biology, Vol 63, Iss , Pp 102733- (2023)
Cellular prion protein (PrPC) protects neurons against oxidative stress damage. This role is lost upon its misfolding into insoluble prions in prion diseases, and correlated with cytoskeletal breakdown and neurophysiological deficits. Here we used mo
Externí odkaz:
https://doaj.org/article/434f51e1d13442429fb7e4e62f8c8170
Autor:
Simote T. Foliaki, Anna Smith, Benjamin Schwarz, Eric Bohrnsen, Catharine M. Bosio, Katie Williams, Christina D. Orrú, Hailey Lachenauer, Bradley R. Groveman, Cathryn L. Haigh
Publikováno v:
PLoS Genetics, Vol 19, Iss 1 (2023)
Fatal familial insomnia (FFI) is a rare neurodegenerative disease caused by a dominantly inherited single amino acid substitution (D178N) within the prion protein (PrP). No in vitro human brain tissue model for this disease has previously been availa
Externí odkaz:
https://doaj.org/article/d2e31581d9e6439da56b147e8cf28856
Autor:
Simote T. Foliaki, Benjamin Schwarz, Bradley R. Groveman, Ryan O. Walters, Natalia C. Ferreira, Christina D. Orrù, Anna Smith, Aleksandar Wood, Olivia M. Schmit, Phoebe Freitag, Jue Yuan, Wenquan Zou, Catharine M. Bosio, James A. Carroll, Cathryn L. Haigh
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-23 (2021)
Abstract The neuro-physiological properties of individuals with genetic pre-disposition to neurological disorders are largely unknown. Here we aimed to explore these properties using cerebral organoids (COs) derived from fibroblasts of individuals wi
Externí odkaz:
https://doaj.org/article/6bd0dd66c2cd46cbb517d6bd6b03291d
Autor:
Bradley R. Groveman, Natalia C. Ferreira, Simote T. Foliaki, Ryan O. Walters, Clayton W. Winkler, Brent Race, Andrew G. Hughson, Gianluigi Zanusso, Cathryn L. Haigh
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Creutzfeldt–Jakob Disease (CJD) is a fatal, currently incurable, neurodegenerative disease. The search for candidate treatments would be greatly facilitated by the availability of human cell-based models of prion disease. Recently, an indu
Externí odkaz:
https://doaj.org/article/349388bbff72452db46c3047ea9cc10f
Autor:
Bradley R. Groveman, Simote T. Foliaki, Christina D. Orru, Gianluigi Zanusso, James A. Carroll, Brent Race, Cathryn L. Haigh
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract For the transmissible, neurogenerative family of prion diseases, few human models of infection exist and none represent structured neuronal tissue. Human cerebral organoids are self-organizing, three-dimensional brain tissues that can be gro
Externí odkaz:
https://doaj.org/article/9d2522f5b8ef46879d6c6efd4b996b79
Autor:
Simote T. Foliaki, Brent Race, Katie Williams, Chase Baune, Bradley R. Groveman, Cathryn L. Haigh
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Prion diseases are progressive, neurodegenerative diseases affecting humans and animals. Also known as the transmissible spongiform encephalopathies, for the hallmark spongiform change seen in the brain, these diseases manifest increased oxidative da
Externí odkaz:
https://doaj.org/article/fd6687d15ac742fca4e0aa6fba46e13b