Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage.

Autor: Simonich CA; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Medical Scientist Training Program, University of Washington School of Medicine, Seattle, WA, 98195, USA., Doepker L; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Ralph D; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Williams JA; Department of Medicinal Chemistry, University of Washington, Seattle, WA, 98195, USA., Dhar A; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Department of Statistics, University of Washington, Seattle, WA, 98195, USA., Yaffe Z; Medical Scientist Training Program, University of Washington School of Medicine, Seattle, WA, 98195, USA., Gentles L; Department of Microbiology, University of Washington, Seattle, WA, 98195, USA.; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Small CT; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Oliver B; Center for Infectious Disease Research, Seattle, WA, 98109, USA., Vigdorovich V; Center for Infectious Disease Research, Seattle, WA, 98109, USA., Mangala Prasad V; Department of Medicinal Chemistry, University of Washington, Seattle, WA, 98195, USA., Nduati R; Department of Pediatrics and Child Health, University of Nairobi, Nairobi, Kenya., Sather DN; Center for Infectious Disease Research, Seattle, WA, 98109, USA., Lee KK; Department of Medicinal Chemistry, University of Washington, Seattle, WA, 98195, USA., Matsen Iv FA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Overbaugh J; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA. joverbau@fredhutch.org.; Medical Scientist Training Program, University of Washington School of Medicine, Seattle, WA, 98195, USA. joverbau@fredhutch.org.

Publikováno v: Nature communications [Nat Commun] 2019 May 16; Vol. 10 (1), pp. 2190. Date of Electronic Publication: 2019 May 16.

Epitope-Independent Purification of Native-Like Envelope Trimers from Diverse HIV-1 Isolates.

Autor: Verkerke HP; Department of Medicinal Chemistry, University of Washington, Seattle, Washington, USA., Williams JA; Department of Medicinal Chemistry, University of Washington, Seattle, Washington, USA., Guttman M; Department of Medicinal Chemistry, University of Washington, Seattle, Washington, USA., Simonich CA; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Liang Y; Department of Medicinal Chemistry, University of Washington, Seattle, Washington, USA., Filipavicius M; Department of Medicinal Chemistry, University of Washington, Seattle, Washington, USA., Hu SL; Department of Pharmaceutics and Washington National Primate Research Center, University of Washington, Seattle, Washington, USA., Overbaugh J; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Lee KK; Department of Medicinal Chemistry, University of Washington, Seattle, Washington, USA kklee@uw.edu.

Publikováno v: Journal of virology [J Virol] 2016 Sep 29; Vol. 90 (20), pp. 9471-82. Date of Electronic Publication: 2016 Sep 29 (Print Publication: 2016).

Characteristics of memory B cells elicited by a highly efficacious HPV vaccine in subjects with no pre-existing immunity.

Autor: Scherer EM; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Smith RA; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Simonich CA; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America; Department of Medicine, University of Washington, Seattle, Washington, United States of America; Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, United States of America., Niyonzima N; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America; Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, United States of America; Uganda Cancer Institute, Kampala, Uganda., Carter JJ; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Galloway DA; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America; Department of Microbiology, University of Washington, Seattle, Washington, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2014 Oct 16; Vol. 10 (10), pp. e1004461. Date of Electronic Publication: 2014 Oct 16 (Print Publication: 2014).