Tis21-gene therapy inhibits medulloblastoma growth in a murine allograft model.

Autor: Dario Presutti, Manuela Ceccarelli, Laura Micheli, Giuliana Papoff, Simonetta Santini, Simone Samperna, Cristiana Lalli, Lorena Zentilin, Giovina Ruberti, Felice Tirone

Publikováno v: PLoS ONE, Vol 13, Iss 3, p e0194206 (2018)

Medulloblastoma (MB), the tumor of the cerebellum, is the most frequent brain cancer in childhood and a major cause of pediatric mortality. Based on gene profiling, four MB subgroups have been identified, i.e., Wnt or Sonic Hedgehog (Shh) types, and

Externí odkaz: https://doaj.org/article/88424198f5f5424ea76328f7dfa38898

In Vitro and In Vivo Effects of the Urokinase Plasminogen Activator Inhibitor WX-340 on Anaplastic Thyroid Cancer Cell Lines

Autor: Enke Baldini, Dario Presutti, Pasqualino Favoriti, Simonetta Santini, Giuliana Papoff, Chiara Tuccilli, Raffaella Carletti, Cira Di Gioia, Eleonora Lori, Iulia Catalina Ferent, Federica Gagliardi, Antonio Catania, Daniele Pironi, Domenico Tripodi, Vito D’Andrea, Salvatore Sorrenti, Giovina Ruberti, Salvatore Ulisse

Publikováno v: International journal of molecular sciences (Online) (2022). doi:10.3390/ijms23073724
info:cnr-pdr/source/autori:Enke Baldini 1, Dario Presutti 2, Pasqualino Favoriti 1, Simonetta Santini 2, Giuliana Papoff 2, Chiara Tuccilli 1, Raffaella Carletti 3, Cira Di Gioia 3, Eleonora Lori 1, Iulia Catalina Ferent 1, Federica Gagliardi 1, Antonio Catania 1, Daniele Pironi 1, Domenico Tripodi 1, Vito D'Andrea 1, Salvatore Sorrenti 1, Giovina Ruberti 2 and Salvatore Ulisse 1/titolo:In Vitro and In Vivo Effects of the Urokinase Plasminogen Activator Inhibitor WX-340 on Anaplastic Thyroid Cancer Cell Lines/doi:10.3390%2Fijms23073724/rivista:International journal of molecular sciences (Online)/anno:2022/pagina_da:/pagina_a:/intervallo_pagine:/volume
International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 3724

Increased expression of the urokinase-type plasminogen activator (uPA) system is associated with tumor invasion, neo-angiogenesis, and metastatic spread, and has been shown to positively correlate with a poor prognosis in several cancer types, includ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26917e84c1538cd593c7ef9522ba7ee2
https://www.mdpi.com/1422-0067/23/7/3724/htm

CASP4 gene silencing in epithelial cancer cells leads to impairment of cell migration, cell-matrix adhesion and tissue invasion

Autor: Giuliana Papoff, Candida Manelfi, Stefano Alemà, Valentina Fustaino, Dario Presutti, Giovina Ruberti, Simonetta Santini, Cristiana Lalli, Giulia Bolasco

Publikováno v: Scientific reports (Nature Publishing Group) 8 (2018). doi:10.1038/s41598-018-35792-8
info:cnr-pdr/source/autori:Papoff Giuliana, Presutti Dario, Lalli Cristiana, Bolasco Giulia, Santini Simonetta, Manelfi Candida, Fustaino Valentina, Alemà Stefano, Ruberti Giovina./titolo:CASP4 gene silencing in epithelial cancer cells leads to impairment of cell migration, cell-matrix adhesion and tissue invasion./doi:10.1038%2Fs41598-018-35792-8/rivista:Scientific reports (Nature Publishing Group)/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:8
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)

Inflammatory caspases, including human caspase-4 (CASP4), play key roles in innate immune responses to promote fusion of phagosomes harboring pathogenic bacteria with lysosomes, halt intracellular replication of pathogens, maturation and secretion of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07a308a50fa5544048abe7b7b0438bc
http://www.cnr.it/prodotto/i/396017

Proteomic profiling of ATM kinase proficient and deficient cell lines upon blockage of proteasome activity

Autor: Andrea Urbani, Daniela Barilà, Carlo Marchetti, Valeria Marzano, Venturina Stagni, Michele Mingardi, Simonetta Santini, Claudia Rossi, Mirco Zucchelli, Annamaria D'Alessandro

Publikováno v: Journal of Proteomics

Ataxia Telangiectasia Mutated (ATM) protein kinase is a key effector in the modulation of the functionality of some important stress responses, including DNA damage and oxidative stress response, and its deficiency is the hallmark of Ataxia Telangiec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f72179a1e89c7fe20dffe7bad1754bb

Molecular Bases of Ataxia Telangiectasia: One Kinase Multiple Functions

Autor: Simonetta Santini, Venturina Stagni, Daniela Barilà

Publikováno v: Genetic Disorders

Ataxia Telangiectasia (A-T) is an autosomal recessive hereditary progressive neurodegener‐ ative and multisystem disease characterized by cerebellar ataxia, telangiectasia, recurrent si‐ nopulmonary infections, variable immunologic defects among

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b9bb718140abee152e021da1fc6605
http://www.intechopen.com/articles/show/title/molecular-bases-of-ataxia-telangiectasia-one-kinase-multiple-functions