Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Simonetta, Falzoni"'
Autor:
Maria Pina Notarangelo, Letizia Penolazzi, Elisabetta Lambertini, Simonetta Falzoni, Pasquale De Bonis, Cristina Capanni, Francesco Di Virgilio, Roberta Piva
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
A comprehensive understanding of the molecules that play key roles in the physiological and pathological homeostasis of the human intervertebral disc (IVD) remains challenging, as does the development of new therapeutic treatments. We recently found
Externí odkaz:
https://doaj.org/article/9535fd74f6e64ed9908505704d26553a
Autor:
Maximilian Wilmes, Carolina Pinto Espinoza, Peter Ludewig, Joschi Stabernack, Arthur Liesz, Annette Nicke, Mathias Gelderblom, Christian Gerloff, Simonetta Falzoni, Eva Tolosa, Francesco Di Virgilio, Björn Rissiek, Nikolaus Plesnilla, Friedrich Koch-Nolte, Tim Magnus
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background Previous studies have demonstrated that purinergic receptors could be therapeutic targets to modulate the inflammatory response in multiple models of brain diseases. However, tools for the selective and efficient targeting of thes
Externí odkaz:
https://doaj.org/article/42a72dde94804cbaafa23cc1ebad1ef5
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9465 (2023)
The discovery of the P2X7 receptor (P2X7R, originally named P2Z) in immune cells, its cloning, and the identification of its role in a multiplicity of immune-mediated diseases raised great hopes for the development of novel and more potent anti-infla
Externí odkaz:
https://doaj.org/article/20c2420eac7a462fbb67c70dd1dfc7fe
Autor:
Marie Soukupová, Silvia Zucchini, Pascal Trempat, Selene Ingusci, Coline Perrier-Biollay, Mario Barbieri, Stefano Cattaneo, Barbara Bettegazzi, Simonetta Falzoni, Hervé Berthommé, Michele Simonato
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 399-412 (2021)
A key factor for developing gene therapy strategies for neurological disorders is the availability of suitable vectors. Currently, the most advanced are adeno-associated vectors that, while being safe and ensuring long-lasting transgene expression, h
Externí odkaz:
https://doaj.org/article/db61931a21d24d9eb643c45feb72c11c
Autor:
Chiara Mazziotta, Carmen Lanzillotti, Marcello Govoni, Simonetta Falzoni, Maria Letizia Tramarin, Elisa Mazzoni, Mauro Tognon, Fernanda Martini, John Charles Rotondo
Publikováno v:
Immunology. 168:671-683
Oncogenic Merkel cell polyomavirus (MCPyV) provokes a widespread and asymptomatic infection in humans. Herein, sera from healthy children and young adults (HC, n = 344) aged 0-20 years old were evaluated for anti-MCPyV immunoglobulin G (IgG) and IgM
Autor:
Anna Pegoraro, Daria Bortolotti, Roberto Marci, Elisabetta Caselli, Simonetta Falzoni, Elena De Marchi, Francesco Di Virgilio, Roberta Rizzo, Elena Adinolfi
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The P2X7 receptor (P2X7R) is an ATP-gated ion channel known for its proinflammatory activity. Despite its participation in host defense against pathogens, the role played in viral infections, notably those caused by herpes viruses, has been seldom st
Externí odkaz:
https://doaj.org/article/2b00f6cbf7994ed7bc06f369d192b911
Autor:
Juana Maria Sanz, Simonetta Falzoni, Mario Luca Morieri, Angelina Passaro, Giovanni Zuliani, Francesco Di Virgilio
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
One of the main risk factors for brain diseases is aging. Recent studies have shown that aging is a progressive degenerative process associated with chronic low-level inflammation. The ATP-gated P2X7 receptor (P2X7R) plays an important role in inflam
Externí odkaz:
https://doaj.org/article/947ce5c16f864216b1e7b83b50b8094f
Autor:
Enrico Raffaele Fantoni, Diego Dal Ben, Simonetta Falzoni, Francesco Di Virgilio, Simon Lovestone, Antony Gee
Publikováno v:
EJNMMI Research, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Background The P2X7 receptor has been shown to play a fundamental role in the initiation and sustenance of the inflammatory cascade. The development of a novel fluorine-18 PET tracer superior and with a longer half-life to those currently av
Externí odkaz:
https://doaj.org/article/d10ee8924b0b41708f71124b7798f3d1
Autor:
John A. Peters, Annette Nicke, Jessica Meades, Brian F. King, Charles Kennedy, Michael F. Jarvis, Samuel J. Fountain, Anna Fortuny-Gomez, Simonetta Falzoni, Francesco Di Virgilio
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
P2X receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on P2X Receptors [49, 146]) have a trimeric topology [118, 128, 144, 197] with two putative TM domains per P2X subunit, gating primarily Na+, K+ and Ca2+, exceptionally Cl-. The Nome
Autor:
Simonetta Falzoni, Paola Chiozzi, Valentina Vultaggio-Poma, Mario Tarantini, Elena Adinolfi, Paola Boldrini, Anna Lisa Giuliani, Dariusz C. Gorecki, Francesco Di Virgilio
Microparticles (MPs) are ubiquitously secreted by all cells and play a fundamental role in numerous biological processes such as cell-to-cell communication, cell differentiation, inflammation, and cell energy transfer. Ligation of the P2X7 receptor (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8354a809353c3e5345df34cfbf7b6a3c
https://doi.org/10.1101/2023.04.18.537325
https://doi.org/10.1101/2023.04.18.537325