Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Simone eFulda"'
Autor:
Thomas G.P. Grünewald, Simone eFulda
Publikováno v:
Frontiers in Oncology, Vol 6 (2016)
Externí odkaz:
https://doaj.org/article/07608cb0f8e44aff97890696fd74624e
Autor:
Rosalie eRidzewski, Diana eRettberg, Kai eDittmann, Nicole eCuvelier, Simone eFulda, Heidi eHahn
Publikováno v:
Frontiers in Oncology, Vol 5 (2015)
Rhabdomyosarcoma (RMS) are the most common soft tissue sarcoma in children and are divided into two major histological subgroups, i.e. embryonal (ERMS) and alveolar RMS (ARMS). RMS can show HEDGEHOG/SMOOTHENED (HH/SMO) signaling activity and several
Externí odkaz:
https://doaj.org/article/bec8b8ba1fbb44dea35a0fb6ed35f31f
Publikováno v:
Frontiers in Oncology, Vol 5 (2015)
Recent genomic studies revealed a high rate of recurrent mutations in the RAS pathway in primary rhabdomyosarcoma (RMS) samples. In the present study, we therefore investigated how oncogenic RAS mutants impinge on the regulation of cell death of RMS
Externí odkaz:
https://doaj.org/article/ae51f1364b314f459cf7fbcb0e745f0d
Autor:
Eva eRettinger, Andreas eGlatthaar, Behnaz eAhangarian Abhari, Sarah eOelsner, Verena ePfirrmann, Sabine eHuenecke, Selim eKuci, Hermann eKreyenberg, Andre M Willasch, Thomas eKlingebiel, Simone eFulda, Peter eBader
Publikováno v:
Frontiers in Pediatrics, Vol 2 (2014)
Allogeneic hematopoietic stem cell transplantation (HSCT) is an established treatment option for high-risk hematological malignancies, and may also be offered to patients with solid malignancies refractory to conventional therapies. In case of patien
Externí odkaz:
https://doaj.org/article/c6fb2d43c2db49cd9c064990b604417b
Autor:
Simone eFulda
Publikováno v:
Frontiers in Oncology, Vol 4 (2014)
Inhibitor of Apoptosis (IAP) proteins are a family of proteins with antiapoptotic functions that contribute to the evasion of apoptosis, a form of programmed cell death. IAP proteins are expressed at high levels in a variety of human cancers includin
Externí odkaz:
https://doaj.org/article/1614ffbb37654ce4a2bc5a5cd0aafd05
Publikováno v:
Frontiers in Oncology, Vol 3 (2013)
Rhabdomyosarcoma (RMS) and Ewing sarcoma (ES) are among the most common pediatric sarcomas (Arndt et al., 2012). Despite sarcomas representing a highly heterogeneous group of tumors, ES and alveolar RMS (ARMS) typically share one common genetic chara
Externí odkaz:
https://doaj.org/article/b04fccd8cec14d89aae876dff5f71ebf
Autor:
Simone eFulda
Publikováno v:
Frontiers in Oncology, Vol 3 (2013)
Apoptosis represents one of the most important forms of cell death in higher organisms and is typically dysregulated in human cancers, including pediatric tumors. This implies that ineffective engagement of cell death programs can contribute to tumor
Externí odkaz:
https://doaj.org/article/57fa22e2ea8046088fb4416168287b5f
Autor:
Simone eFulda
Publikováno v:
Frontiers in Oncology, Vol 3 (2013)
Since most anticancer therapies including immunotherapy trigger programmed cell death in cancer cells, defective cell death programs can lead to treatment resistance and tumor immune escape. Therefore, evasion of programmed cell death may provide one
Externí odkaz:
https://doaj.org/article/8e4185a048914e46b0795012177a7d8b
Autor:
Simone eFulda
Publikováno v:
Frontiers in Oncology, Vol 2 (2012)
Signaling via the intrinsic (mitochondrial) pathway of apoptosis represents one of the critical signal transduction cascades that control the regulation of cell death. This pathway is typically altered in human cancers, thereby providing a suitable t
Externí odkaz:
https://doaj.org/article/093a9c527fcd43cfb6fe40a7464fd7ff
Autor:
Eva eRettinger, Vida eMeyer, Hermann eKreyenberg, Andreas eVolk, Selim eKuci, Andre eWillasch, Ewa eKoscielniak, Simone eFulda, Winfried eWels, Halvard eBoenig, Thomas eKlingebiel, Peter eBader
Publikováno v:
Frontiers in Oncology, Vol 2 (2012)
Allogeneic stem cell transplantation (allo-SCT) has become an important treatment modality for patients with high risk acute myeloid leukemia (AML) and is also under investigation for soft tissue sarcomas. The therapeutic success is still limited by
Externí odkaz:
https://doaj.org/article/3b376ad7b03e42619e49cb025ef81677