Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Simone Zaramella"'
Autor:
Jörg Habermann, Stefania Colarusso, Immacolata Conte, Marcello Di Filippo, Caterina Ercolani, Maria Cecilia Palumbi, Maria del Rosario Rico Ferreira, Simone Zaramella, Angela C. Mackay, Frank Narjes, Ian Stansfield
Publikováno v:
Synlett. 2011:1527-1532
The development of a scalable chiral synthesis for the HCV NS5B inhibitor MK-3281 is being reported. Several alternative routes were explored and are being described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b1088cc8404a4ef3095848cb2384440
https://doi.org/10.1055/s-0030-1260790
https://doi.org/10.1055/s-0030-1260790
Autor:
Paola Baiocco, Angela C. Mackay, Jörg Habermann, Frank Narjes, Raffaele De Francesco, Caterina Ercolani, Giovanni Migliaccio, Stefania Di Marco, Geert Leroux-Roels, Philip Meuleman, Ralph Laufer, Simone Zaramella, Stefania Colarusso, Immacolata Conte, Fabrizio Fiore, Michael Rowley, Sergio Altamura, Maria del Rosario Rico Ferreira, Benedetta Crescenzi, Uwe Koch, Ian Stansfield, Claudio Giuliano, Maria-Cecilia Palumbi, Marco Ferrara
Publikováno v:
Journal of Medicinal Chemistry. 54:289-301
Infections caused by hepatitis C virus (HCV) are a significant world health problem for which novel therapies are in urgent demand. The polymerase of HCV is responsible for the replication of viral genome and has been a prime target for drug discover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82030f2a14c890d541baefe4cd5f15d9
https://doi.org/10.1021/jm1013105
https://doi.org/10.1021/jm1013105
Publikováno v:
Journal of the American Chemical Society. 126:14029-14035
We describe the development of a solid-phase technique for the synthesis of 5'-peptide-oligonucleotide conjugates (POCs) with a uniform protection strategy for the nucleic acid and the peptide fragments. On the alpha-amino function, the amino acid bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b6f8e7f90df84f1cd05874e2212dfe
https://doi.org/10.1021/ja046945o
https://doi.org/10.1021/ja046945o
Publikováno v:
European Journal of Organic Chemistry. 2003:2454-2461
Fmoc-histidine derivatives protected with 2,6-dimethoxybenzoyl (2,6-Dmbz) units, either on the τ- (1) or on the π-position (2) of the imidazole residue, have been prepared and applied to the synthesis of the dipeptide Fmoc-His(2,6-Dmbz)-Val-OMe, wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fff8314f1afc1d9cff4f22b1e02f55e4
https://doi.org/10.1002/ejoc.200200668
https://doi.org/10.1002/ejoc.200200668
Publikováno v:
Organic Process Research & Development. 4:225-231
A new process for the preparation of large amounts of thioate oligonucleotides in a quasi-classical solution condition is described. This method takes advantage of the use of poly(ethylene glycol) as a soluble, inert support during the synthesis. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68831559aed65a8fc58632727e139be
https://doi.org/10.1021/op990096l
https://doi.org/10.1021/op990096l
Autor:
Simone Zaramella, G. M. Bonora
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 14:809-812
The use of the H-phosphonate chemistry for its possible utilization in the liquid phase synthesis of oligonucleotides has been investigated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ba62141286e25e15fd1c40120b02ed8
https://doi.org/10.1080/15257779508012477
https://doi.org/10.1080/15257779508012477
Autor:
Frank, Narjes, Benedetta, Crescenzi, Marco, Ferrara, Jörg, Habermann, Stefania, Colarusso, Maria del Rosario Rico, Ferreira, Ian, Stansfield, Angela Claire, Mackay, Immacolata, Conte, Caterina, Ercolani, Simone, Zaramella, Maria-Cecilia, Palumbi, Philip, Meuleman, Geert, Leroux-Roels, Claudio, Giuliano, Fabrizio, Fiore, Stefania, Di Marco, Paola, Baiocco, Uwe, Koch, Giovanni, Migliaccio, Sergio, Altamura, Ralph, Laufer, Raffaele, De Francesco, Michael, Rowley
Infections caused by hepatitis C virus (HCV) are a significant world health problem for which novel therapies are in urgent demand. The polymerase of HCV is responsible for the replication of viral genome and has been a prime target for drug discover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ab8bf41cf50a06afb25e7d53c447a249
http://hdl.handle.net/11573/1540505
http://hdl.handle.net/11573/1540505
Publikováno v:
Chembiochem : a European journal of chemical biology. 11(18)
Several different cationic nonapeptides have been synthesized and investigated with respect to how they can influence the thermal melting of 2'-O-methylRNA/RNA and DNA/DNA duplexes. Each peptide has a C-terminal L-phenylalanine unit and is otherwise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ff915f084159d8233eab04946040cb
https://pubmed.ncbi.nlm.nih.gov/21110373
https://pubmed.ncbi.nlm.nih.gov/21110373
Autor:
Francesco M. Veronese, Gian Maria Bonora, Valentina F. Zarytova, Nina I. Komarova, D. Pishiniyi, E. M. Ivanova, P. E. Vorobjev, Simone Zaramella
Publikováno v:
Nucleosides and Nucleotides. 18:1723-1725
The effect of the different structures of high-molecular weight poly(ethylen glycol) chains on the biological properties of the conjugated antisense oligonucleotide has been investigated and compared.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84696a85efefeaa20b757e0128f64ba2
https://doi.org/10.1080/07328319908044834
https://doi.org/10.1080/07328319908044834
Publikováno v:
The Journal of organic chemistry. 68(19)
The positioning of the imidazole protecting group of several histidine derivatives was determined by means of (1)H-(15)N heteronuclear multiple-bond correlation NMR experiments. The cross-peak originated from the three-bond correlation between the hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3741bb3dc51f79712075c9eb296036f7
https://pubmed.ncbi.nlm.nih.gov/12968911
https://pubmed.ncbi.nlm.nih.gov/12968911