Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Simone Thum"'
Autor:
Maia Datunashvili, Michael Hollmann, Simone Thum, Julian A. Schreiber, Bernhard Wünsch, Guiscard Seebohm, Dirk Schepmann, Bastian Frehland, Thomas Budde, Nathalie Strutz-Seebohm
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-14 (2019)
N-methyl-D-aspartate receptors (NMDARs), especially GluN2B-containing NMDARs, are associated with neurodegenerative diseases like Parkinson, Alzheimer and Huntington based on their high Ca2+ conductivity. Overactivation leads to high intracellular Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b9cb0ac937ed617302c69948de6bb1
http://link.springer.com/article/10.1038/s42003-019-0645-6
http://link.springer.com/article/10.1038/s42003-019-0645-6
Autor:
Marta Pujol, Francisco R. Nieto, Eva Ayet, Bernhard Wünsch, Simone Thum, Simon M. Ametamey, Dirk Schepmann
Publikováno v:
European Journal of Medicinal Chemistry. 177:47-62
The class of tetrahydro-1H-3-benzazepines was systematically modified in 1-, 3- and 7-position. In particular, a F-atom was introduced in β- or γ-position of the 4-phenylbutyl side chain in 3-position. Ligands with the F-atom in γ-position possess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9363ed2e487270d664572d1358e3b81c
https://doi.org/10.1016/j.ejmech.2019.05.034
https://doi.org/10.1016/j.ejmech.2019.05.034
Autor:
Frederik Börgel, Inés Alvarez, Elisabeth Kronenberg, Melanie Bergkemper, Raquel F. Reinoso, Constantin G. Daniliuc, Dirk Schepmann, Bernhard Wünsch, Peter Brust, Simone Thum, Francisco R. Nieto
Publikováno v:
Journal of Medicinal Chemistry 61(2018), 9666-9690
In order to detect novel σ receptor ligands, the rigit spiro [[2]benzopyran-1,1'-cyclohexan]-4'-one was connected with amino moieties derived from σ2 receptor preferring lead compounds resulting in mixtures of trans- and cis-configured amines 6, 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cf0bd4445bc74d19af06e95ef3ec41
https://doi.org/10.1021/acs.jmedchem.8b01183
https://doi.org/10.1021/acs.jmedchem.8b01183
Autor:
Christina Weiss, Simone Thum, Anna Junker, Natalia V. Ortiz Zacarías, Artur K. Kokornaczyk, Henk de Vries, Masato Kitamura, Bernhard Wünsch, Laura H. Heitman, Michael Koch, Tomoaki Seki, Nuska Tschammer, Monica De Maria, Dirk Schepmann
Publikováno v:
European Journal of Medicinal Chemistry, 135, 401-413
Targeting CCR2 and CCR5 receptors is considered as promising concept for the development of novel antiinflammatory drugs. Herein, we present the development of the first probe-dependent positive allosteric modulator (PAM) of CCR5 receptors with a 2-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6fce09f3c2af366b82d6e122f1b6a0b
https://doi.org/10.1016/j.ejmech.2017.04.046
https://doi.org/10.1016/j.ejmech.2017.04.046
Publikováno v:
Zeitschrift für Naturforschung B. 72:421-424
Chemokines (chemoattractant cytokines) together with their receptors represent key players in inflammatory processes. In order to develop novel chemokine CCR2 and CCR5 receptor antagonists, 2-benz-azepin-1-one 5 was prepared, which showed promising C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30bac7e45377d73bcf7b367c138bfa70
https://doi.org/10.1515/znb-2017-0030
https://doi.org/10.1515/znb-2017-0030
Publikováno v:
MedChemComm. 8:975-981
The influence of an F-atom in the side chain of benzo[7]annulen-7-amines on the affinity towards GluN2B subunit containing NMDA receptors and the selectivity over related receptors was investigated. The synthesis of 5a and 5b was performed by reducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad3a6d87c700830baf23cf3a974f6e6
https://doi.org/10.1039/c6md00621c
https://doi.org/10.1039/c6md00621c
Autor:
Simone, Thum, Dirk, Schepmann, Eva, Ayet, Marta, Pujol, Francisco R, Nieto, Simon M, Ametamey, Bernhard, Wünsch
Publikováno v:
European journal of medicinal chemistry. 177
The class of tetrahydro-1H-3-benzazepines was systematically modified in 1-, 3- and 7-position. In particular, a F-atom was introduced in β- or γ-position of the 4-phenylbutyl side chain in 3-position. Ligands with the F-atom in γ-position possess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31c7ea9f1d384855893ef97a7f6a946e
https://pubmed.ncbi.nlm.nih.gov/31129453
https://pubmed.ncbi.nlm.nih.gov/31129453
Autor:
Julian A, Schreiber, Dirk, Schepmann, Bastian, Frehland, Simone, Thum, Maia, Datunashvili, Thomas, Budde, Michael, Hollmann, Nathalie, Strutz-Seebohm, Bernhard, Wünsch, Guiscard, Seebohm
Publikováno v:
Communications Biology
N-methyl-D-aspartate receptors (NMDARs), especially GluN2B-containing NMDARs, are associated with neurodegenerative diseases like Parkinson, Alzheimer and Huntington based on their high Ca2+ conductivity. Overactivation leads to high intracellular Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ab7e3798a4c00092e21fe613e4e1f30
https://pubmed.ncbi.nlm.nih.gov/31754650
https://pubmed.ncbi.nlm.nih.gov/31754650
Autor:
Raquel F. Reinoso, Simon M. Ametamey, Inés Alvarez, Bernhard Wünsch, Dirk Schepmann, Simone Thum
Publikováno v:
Journal of labelled compoundsradiopharmaceuticals. 62(8)
Because of their neuroprotective potential, GluN2B-selective ligands are of great interest for the treatment of various neurological and neurodegenerative disorders. Fluorinated benzo[7]annulen-7-amines, capable for PET, were synthesized by combining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7aa8c83f2a16eae6c771c9fd8acad4
https://pubmed.ncbi.nlm.nih.gov/30850991
https://pubmed.ncbi.nlm.nih.gov/30850991
Publikováno v:
ChemMedChem. 13(23)
The 4-benzylpiperidine moiety is a central structural element of potent N-methyl-d-aspartate (NMDA) receptor antagonists containing the GluN2B subunit. To obtain novel GluN2B ligands suitable for positron emission tomography, the benzylpiperidine moi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba84fa92bae0f2deb780936d0466cd25
https://pubmed.ncbi.nlm.nih.gov/30312542
https://pubmed.ncbi.nlm.nih.gov/30312542