Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Simone Tangermann"'
Autor:
Jan Pencik, Cecile Philippe, Michaela Schlederer, Emine Atas, Matteo Pecoraro, Sandra Grund-Gröschke, Wen (Jess) Li, Amanda Tracz, Isabel Heidegger, Sabine Lagger, Karolína Trachtová, Monika Oberhuber, Ellen Heitzer, Osman Aksoy, Heidi A. Neubauer, Bettina Wingelhofer, Anna Orlova, Nadine Witzeneder, Thomas Dillinger, Elisa Redl, Georg Greiner, David D’Andrea, Johnny R. Östman, Simone Tangermann, Ivana Hermanova, Georg Schäfer, Felix Sternberg, Elena E. Pohl, Christina Sternberg, Adam Varady, Jaqueline Horvath, Dagmar Stoiber, Tim I. Malcolm, Suzanne D. Turner, Eileen E. Parkes, Brigitte Hantusch, Gerda Egger, Stefan Rose-John, Valeria Poli, Suneil Jain, Chris W. D. Armstrong, Gregor Hoermann, Vincent Goffin, Fritz Aberger, Richard Moriggl, Arkaitz Carracedo, Cathal McKinney, Richard D. Kennedy, Helmut Klocker, Michael R. Speicher, Dean G. Tang, Ali A. Moazzami, David M. Heery, Marcus Hacker, Lukas Kenner
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-25 (2023)
Abstract Prostate cancer (PCa) is a common and fatal type of cancer in men. Metastatic PCa (mPCa) is a major factor contributing to its lethality, although the mechanisms remain poorly understood. PTEN is one of the most frequently deleted genes in m
Externí odkaz:
https://doaj.org/article/55713eefba5d493d89c7d396451b3eb7
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
This case study aims to describe the dilemma faced when exposing rats to very high concentrations of fine, pulverulent materials for acute inhalation studies and to address the regulatory question of whether the effects seen here are relevant to huma
Externí odkaz:
https://doaj.org/article/b7f7322c9b3a48d6816308186fd4486a
Autor:
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W. Zimmerman, Elisabeth Gurnhofer, Ivonne A. Montes-Mojarro, Brian J. Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K. Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D. Turner, A. Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Anaplastic large cell lymphoma (ALCL) is an aggressive T-cell lymphoma often with poor prognosis. To identify genes defining ALCL cell state and dependencies, the authors here characterize ALCL-specific super-enhancers and describe the BATF3/IL-2R−
Externí odkaz:
https://doaj.org/article/6005c21ca6e84b989b1eb0469795a79b
Autor:
Katja-Nicole Adamik, Michael H. Stoffel, Simone Tangermann, Bettina de Breuyn Dietler, Nadine Stokar-Regenscheit
Publikováno v:
Frontiers in Veterinary Science, Vol 8 (2022)
Objective: Intravenous hydroxyethyl starch (HES) solutions are potentially nephrotoxic due to rapid renal tissue uptake, subsequent osmotic nephrosis, and long-lasting intracellular storage. This study aimed to investigate the severity of intracellul
Externí odkaz:
https://doaj.org/article/678c3271d7324b63aba58920e563669b
Autor:
Ricky M. Trigg, Liam C. Lee, Nina Prokoph, Leila Jahangiri, C. Patrick Reynolds, G. A. Amos Burke, Nicola A. Probst, Miaojun Han, Jamie D. Matthews, Hong Kai Lim, Eleanor Manners, Sonia Martinez, Joaquin Pastor, Carmen Blanco-Aparicio, Olaf Merkel, Ines Garces de los Fayos Alonso, Petra Kodajova, Simone Tangermann, Sandra Högler, Ji Luo, Lukas Kenner, Suzanne D. Turner
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Anaplastic lymphoma kinase (ALK) inhibitors are currently being considered in neuroblastoma (NB), but its acquired resistance is reported in non-small cell lung cancers. Here, the authors have found PIM1 overexpression decreases sensitivity to ALK in
Externí odkaz:
https://doaj.org/article/f2be0a65707b41b5b2ef0367cf79b3cb
Autor:
Elvin D. de Araujo, Fettah Erdogan, Heidi A. Neubauer, Deniz Meneksedag-Erol, Pimyupa Manaswiyoungkul, Mohammad S. Eram, Hyuk-Soo Seo, Abdul K. Qadree, Johan Israelian, Anna Orlova, Tobias Suske, Ha T. T. Pham, Auke Boersma, Simone Tangermann, Lukas Kenner, Thomas Rülicke, Aiping Dong, Manimekalai Ravichandran, Peter J. Brown, Gerald F. Audette, Sarah Rauscher, Sirano Dhe-Paganon, Richard Moriggl, Patrick T. Gunning
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Hyper-activated STAT5B and its disease-causing variants are of interest as cancer drug targets. Here the authors combine cell based studies, X-ray crystallography, biophysical experiments and MD simulations to structurally and functionally characteri
Externí odkaz:
https://doaj.org/article/f8b672c48f8f4b91911646f53ce84f0b
Autor:
Nitesh Shirsath, Karin Wagner, Simone Tangermann, Michaela Schlederer, Christian Ringel, Lukas Kenner, Bernhard Brüne, Peter Wolf
Publikováno v:
Acta Dermato-Venereologica, Vol 98, Iss 6, Pp 576-584 (2018)
The effects of 8-Methoxypsoralen plus ultraviolet A (PUVA) or ultraviolet B (UVB) alone on imiquimod-induced psoriasis were examined in a mouse model. Mouse skin was treated with repetitive sub-phototoxic doses of PUVA or UVB before or during the ind
Externí odkaz:
https://doaj.org/article/f52ce1cad1b3494f993bb480f16be59c
Autor:
Jan Pencik, Cecile Philippe, Michaela Schlederer, Matteo Pecoraro, Sandra Grund-Gröschke, Wen Jess Li, Amanda Tracz, Isabel Heidegger, Sabine Lagger, Karolína Trachtová, Monika Oberhuber, Ellen Heitzer, Osman Aksoy, Heidi A. Neubauer, Bettina Wingelhofer, Anna Orlova, Nadine Witzeneder, Thomas Dillinger, Elisa Redl, Georg Greiner, David D’Andrea, Johnny R. Östman, Simone Tangermann, Ivana Hermanova, Georg Schäfer, Adam Varady, Jaqueline Horvath, Dagmar Stoiber, Timothy I. Malcolm, Suzanne D. Turner, Eileen Parkes, Brigitte Hantusch, Gerda Egger, Stefan Rose-John, Valeria Poli, Suneil Jain, Chris W.D. Armstrong, Gregor Hoermann, Vincent Goffin, Fritz Aberger, Richard Moriggl, Arkaitz Carracedo, Cathal McKinney, Richard D Kennedy, Helmut Klocker, Michael R. Speicher, Dean G. Tang, Matthias Mann, Ali A. Moazzami, David M. Heery, Marcus Hacker, Lukas Kenner
Prostate cancer (PCa) lethality is driven by its progression to a metastatic castration-resistant state, yet the signaling mechanisms underlying metastatic spread remain unknown. Here we show that STAT3 converges with the LKB1/mTORC1 and CREB to cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f5a76027237f1ffa67d29407f79e657
https://doi.org/10.1101/2022.08.25.504915
https://doi.org/10.1101/2022.08.25.504915
Autor:
Sabrina Hartenbach, Christopher J. Roberts, Martin Susani, Heidi A. Neubauer, Olaf Merkel, Lukas Kenner, Jan Oppelt, Marcus Hacker, Adam Varady, Markus Mitterhauser, Boris Tichy, Shahrokh F. Shariat, Judith Stangl-Kremser, Jan Pencik, Richard Moriggl, Šárka Pospíšilová, Theresa Balber, Simone Tangermann, Suzanne D. Turner, Pascal A. T. Baltzer, Zoran Culig, Rodrig Marculescu, Melanie R. Hassler, David M. Heery, Gregor Hoermann, Gerda Egger, Jonathan B Whitchurch, Markus Hartenbach, Osman Aksoy, Georg Greiner, Ali A. Moazzami, Michaela Schlederer, Bismoy Mazumder, Gero Kramer, Andrea Haitel, Cécile Philippe, Merima Herac
Publikováno v:
International Journal of Cancer
Androgen deprivation therapy (ADT) remains a key approach in the treatment of prostate cancer (PCa). However, PCa inevitably relapses and becomes ADT resistant. Besides androgens, there is evidence that thyroid hormone thyroxine (T4) and its active f
Autor:
Petra Kodajova, Sonia Sánchez Martínez, Nicola A. Probst, Liam C. Lee, Ines Garces de los Fayos Alonso, Miaojun Han, Sandra Högler, Joaquín Pastor, G. A. Amos Burke, C. Patrick Reynolds, Hong Kai Lim, Eleanor Manners, Carmen Blanco-Aparicio, Leila Jahangiri, Jamie D. Matthews, Ji Luo, Suzanne D. Turner, Nina Prokoph, Simone Tangermann, Lukas Kenner, Olaf Merkel, Ricky M Trigg
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nature Communications
Repisalud
Instituto de Salud Carlos III (ISCIII)
Resistance to anaplastic lymphoma kinase (ALK)-targeted therapy in ALK-positive non-small cell lung cancer has been reported, with the majority of acquired resistance mechanisms relying on bypass signaling. To proactively identify resistance mechanis