Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Simone Susser"'
Autor:
Julia Dietz, Daniel Rupp, Simone Susser, Johannes Vermehren, Kai-Henrik Peiffer, Natalie Filmann, Dimitra Bon, Thomas Kuntzen, Stefan Mauss, Georgios Grammatikos, Dany Perner, Caterina Berkowski, Eva Herrmann, Stefan Zeuzem, Ralf Bartenschlager, Christoph Sarrazin
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156731 (2016)
Triple therapy of chronic hepatitis C virus (HCV) infection with boceprevir (BOC) or telaprevir (TVR) leads to virologic failure in many patients which is often associated with the selection of resistance-associated variants (RAVs). These resistance
Externí odkaz:
https://doaj.org/article/f0b9bf41fdc84f7685b902ea5dba99e9
Autor:
Julia Dietz, Simone Susser, Caterina Berkowski, Dany Perner, Stefan Zeuzem, Christoph Sarrazin
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134395 (2015)
Different highly effective interferon-free treatment options for chronic hepatitis C virus (HCV) infection are currently available. Pre-existence of resistance associated variants (RAVs) to direct antiviral agents (DAAs) reduces sustained virologic r
Externí odkaz:
https://doaj.org/article/33dcd97ac3924e06aa66aa6b8b4e8d9a
Autor:
Steffen B Wiegand, Benjamin Heidrich, Simone Susser, Magdalena Rogalska-Taranta, Jörg Petersen, Klaus H W Böker, Natalia Grigorian, Ralph Link, Uwe Naumann, Christine John, Stefan Lueth, Peter Malfertheiner, Michael P Manns, Heiner Wedemeyer, Christoph Sarrazin, Markus Cornberg
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145622 (2015)
BACKGROUND:SNPs near the interferon lambda (IFNL) 3 gene are predictors for sustained virological response (SVR) in patients with chronic hepatitis C genotype (GT) 1. In addition, a dinucleotide frame shift in ss469415590 was described, which generat
Externí odkaz:
https://doaj.org/article/7667aca06f0b48d7959fd0f8abc267fa
Autor:
Simone Susser, Eva Herrmann, Christian Lange, Nabila Hamdi, Tobias Müller, Thomas Berg, Dany Perner, Stefan Zeuzem, Christoph Sarrazin
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112592 (2014)
BACKGROUND:IL28B gene polymorphism is the best baseline predictor of response to interferon alfa-based antiviral therapies in chronic hepatitis C. Recently, a new IFN-L4 polymorphism was identified as first potential functional variant for induction
Externí odkaz:
https://doaj.org/article/a550a534cfa84918978e5435fde14aa7
Autor:
Benjamin Maasoumy, Bela Hunyady, Vincenza Calvaruso, Mihály Makara, Johannes Vermehren, Attila Haragh, Simone Susser, Birgit Bremer, Gavin Cloherty, Michael P Manns, Antonio Craxì, Heiner Wedemeyer, Christoph Sarrazin
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e110857 (2014)
On-treatment HCV RNA measurements are crucial for the prediction of a sustained virological response (SVR) and to determine treatment futility during protease inhibitor-based triple therapies. In patients with advanced liver disease an accurate risk/
Externí odkaz:
https://doaj.org/article/9c48263b792c4e329d97dcc861cbdd68
Autor:
Georgios Grammatikos, Christian Lange, Simone Susser, Susanne Schwendy, Nektarios Dikopoulos, Peter Buggisch, Jens Encke, Gerlinde Teuber, Tobias Goeser, Robert Thimme, Hartwig Klinker, Wulf O Boecher, Ewert Schulte-Frohlinde, Marissa Penna-Martinez, Klaus Badenhoop, Stefan Zeuzem, Thomas Berg, Christoph Sarrazin
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87974 (2014)
Different parameters have been determined for prediction of treatment outcome in hepatitis c virus genotype 1 infected patients undergoing pegylated interferon, ribavirin combination therapy. Results on the importance of vitamin D levels are conflict
Externí odkaz:
https://doaj.org/article/ea247f6598fb4390816d1931d898751d
Autor:
Janett Fischer, Stephan Böhm, Tobias Müller, Heiko Witt, Christoph Sarrazin, Simone Susser, Pascal Migaud, Eckart Schott, Graeme Stewart, Annika Brodzinski, Balazs Fülöp, Florian van Bömmel, Jacob George, Thomas Berg
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77530 (2013)
BACKGROUND & AIMS:Genetic variations near the interferon lambda 3 gene (IFNL3, IL28B) are the most powerful predictors for sustained virologic response (SVR) in patients with chronic hepatitis C virus (HCV) infection, compared to other biochemical or
Externí odkaz:
https://doaj.org/article/ca9b104f112b431ea39a88fd88704cc9
Autor:
Martin-Walter Welker, David Reichert, Simone Susser, Christoph Sarrazin, Yolanda Martinez, Eva Herrmann, Stefan Zeuzem, Albrecht Piiper, Bernd Kronenberger
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30796 (2012)
AIM: Cellular CD81 is a well characterized hepatitis C virus (HCV) entry factor, while the relevance of soluble exosomal CD81 in HCV pathogenesis is poorly defined. We performed a case-control study to investigate whether soluble CD81 in the exosomal
Externí odkaz:
https://doaj.org/article/4af9245b1036452886be390d8a9c22ae
Autor:
Johannes Vermehren, Jörn Lötsch, Simone Susser, Sabine Wicker, Annemarie Berger, Stefan Zeuzem, Christoph Sarrazin, Alexandra Doehring
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32605 (2012)
BACKGROUND AND AIMS: Chronic infection with the hepatitis B virus (HBV) is a major health issue worldwide. Recently, single nucleotide polymorphisms (SNPs) within the human leukocyte antigen (HLA)-DP locus were identified to be associated with HBV in
Externí odkaz:
https://doaj.org/article/e9473e139601497b94ce2a3b7c565f47
Autor:
Verena Bihrer, Oliver Waidmann, Mireen Friedrich-Rust, Nicole Forestier, Simone Susser, Jörg Haupenthal, Martin Welker, Ying Shi, Jan Peveling-Oberhag, Andreas Polta, Michael von Wagner, Heinfried H Radeke, Christoph Sarrazin, Jörg Trojan, Stefan Zeuzem, Bernd Kronenberger, Albrecht Piiper
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26971 (2011)
BACKGROUND: MicroRNA-21 (miR-21) is up-regulated in tumor tissue of patients with malignant diseases, including hepatocellular carcinoma (HCC). Elevated concentrations of miR-21 have also been found in sera or plasma from patients with malignancies,
Externí odkaz:
https://doaj.org/article/65901544414a4cefa9867b93cc8973e9