Zobrazeno 1 - 10
of 266
pro vyhledávání: '"Simone Sidoli"'
Autor:
Xiaofan Yu, Gabrielle Benitez, Peter Tszki Wei, Sofia V. Krylova, Ziyi Song, Li Liu, Meifan Zhang, Alus M. Xiaoli, Henna Wei, Fenfen Chen, Simone Sidoli, Fajun Yang, Kosaku Shinoda, Jeffrey E. Pessin, Daorong Feng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Aging, chronic high-fat diet feeding, or housing at thermoneutrality induces brown adipose tissue (BAT) involution, a process characterized by reduction of BAT mass and function with increased lipid droplet size. Single nuclei RNA sequencing
Externí odkaz:
https://doaj.org/article/7996ce0e511449b6b2d79881227087c6
Autor:
Marcos Schaan Profes, Araven Tiroumalechetty, Neel Patel, Stephanie S. Lauar, Simone Sidoli, Peri T. Kurshan
Publikováno v:
PLoS Biology, Vol 22, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/c3f78c88467046ed905ac05e260bf385
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The role of a scientist is at first not so different from a philosopher. They both need to question common thinking and evaluate whether reality is not as we always thought. Based on this, we need to design hypotheses, experiments, and analyses to pr
Externí odkaz:
https://doaj.org/article/4b3eeffe61d04795bbf9daea34cab980
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-16 (2023)
Abstract Background KDM5 family proteins are multi-domain regulators of transcription that when dysregulated contribute to cancer and intellectual disability. KDM5 proteins can regulate transcription through their histone demethylase activity in addi
Externí odkaz:
https://doaj.org/article/58e77dd544d441039134b2ff7d072bf7
Autor:
Aakash Mahant Mahant, Fatima Estrada Trejo, Jennifer T. Aguilan, Simone Sidoli, Sallie R. Permar, Betsy C. Herold
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107648- (2023)
Summary: Antibody-dependent cellular cytotoxicity (ADCC) is associated with protection against neonatal herpes. We hypothesized that placental transfer of ADCC-mediating herpes simplex virus (HSV) immunoglobulin G (IgG) is influenced by antigenic tar
Externí odkaz:
https://doaj.org/article/48d8580a2cbb4759a4a1e8fcf61519e0
Publikováno v:
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-14 (2022)
Abstract Background Three-dimensional (3D) cell culture has emerged as an alternative approach to 2D flat culture to model more accurately the phenotype of solid tissue in laboratories. Culturing cells in 3D more precisely recapitulates physiological
Externí odkaz:
https://doaj.org/article/2629b35bb6d5457a992ce86fc0f95708
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107170- (2023)
Summary: Tet2 is a member of the Ten-eleven translocation (Tet1/2/3) family of enzymes and is expressed in embryonic stem cells (ESCs). It demethylates DNA (catalytic functions) and partners with chromatin modifiers (noncatalytic functions) to regula
Externí odkaz:
https://doaj.org/article/77f022fa5ce340e3b4645581d964662f
Autor:
Carl A. Pierce, Lip Nam Loh, Holly R. Steach, Natalia Cheshenko, Paula Preston-Hurlburt, Fengrui Zhang, Stephanie Stransky, Leah Kravets, Simone Sidoli, William Philbrick, Michel Nassar, Smita Krishnaswamy, Kevan C. Herold, Betsy C. Herold
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 11 (2023)
Herpes simplex virus type 2 (HSV-2) coinfection is associated with increased HIV-1 viral loads and expanded tissue reservoirs, but the mechanisms are not well defined. HSV-2 recurrences result in an influx of activated CD4+ T cells to sites of viral
Externí odkaz:
https://doaj.org/article/f5b10ba6f97a40c4b40cb5a78e9c44a7
Autor:
Allison B. Herman, Dimitrios Tsitsipatis, Carlos Anerillas, Krystyna Mazan-Mamczarz, Angelica E. Carr, Jordan M. Gregg, Mingyi Wang, Jing Zhang, Marc Michel, Charnae’ A. Henry-Smith, Sophia C. Harris, Rachel Munk, Jennifer L. Martindale, Yulan Piao, Jinshui Fan, Julie A. Mattison, Supriyo De, Kotb Abdelmohsen, Robert W. Maul, Toshiko Tanaka, Ann Zenobia Moore, Megan E. DeMouth, Simone Sidoli, Luigi Ferrucci, Yie Liu, Rafael de Cabo, Edward G. Lakatta, Myriam Gorospe
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
Senescent vascular smooth muscle cells (VSMCs) accumulate in the vasculature with age and tissue damage and secrete factors that promote atherosclerotic plaque vulnerability and disease. Here, we report increased levels and activity of dipeptidyl pep
Externí odkaz:
https://doaj.org/article/097cd3f88b2846ebbe4f877f1734a991
Autor:
Rukmani Lekhraj, Shirin Lalezari, Jennifer T. Aguilan, Jiyue Qin, Simone Sidoli, Wenzhu Mowrey, Seema Gollamudi, Parviz Lalezari
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The immune system has been described to play a role in the development of Alzheimer’s disease (AD), but the distribution of immunoglobulins and their subclasses in brain tissue has not been explored. In this study, examination of pathologi
Externí odkaz:
https://doaj.org/article/3b422706b0004bd5a08cf81d043baf27