Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Simone Schrank"'
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159840 (2016)
The thermal and structural evolutions associated to active pharmaceutical ingredient (API) purity are monitored using a laboratory instrument (S3-MicroCaliX) allowing simultaneous time-resolved X-ray scattering at both wide and small angles (SWAXS) a
Externí odkaz:
https://doaj.org/article/7adf8293b8244a77ab8588a1f81bde15
Autor:
Eva Roblegg, Simone Schrank, Johannes Khinast, Josip Matić, Ramona Baumgartner, Stephan Laske
Publikováno v:
International Journal of Pharmaceutics. 506:35-45
Previously, we introduced a one-step nano-extrusion (NANEX) process for transferring aqueous nano-suspensions into solid formulations directly in the liquid phase. Nano-suspensions were fed into molten polymers via a side-feeding device and excess wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a09c7001d4e677da703d72e8880bf3
https://doi.org/10.1016/j.ijpharm.2016.04.029
https://doi.org/10.1016/j.ijpharm.2016.04.029
Autor:
Eva Roblegg, Simone Schrank, Johannes Khinast, Nicole Jedinger, Johannes M. Fischer, Karlheinz Breinhälter
Publikováno v:
AAPS PharmSciTech. 17:68-77
This study focused on the development of flexible (i.e., deformable) multiple-unit pellets that feature (i) a prolonged drug release, (ii) drug abuse deterrence, and (iii) a minimal risk of alcohol-induced dose dumping (ADD). Deformable pellets were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae35ea486cc0a2b22a6fe194179a62c
https://doi.org/10.1208/s12249-015-0373-2
https://doi.org/10.1208/s12249-015-0373-2
Autor:
Birthe Kann, M Hainschitz, Eva Roblegg, Simone Schrank, Johannes Khinast, Maike Windbergs, Eva-Maria Saurugger, Benjamin J. Glasser
Publikováno v:
International Journal of Pharmaceutics. 478:779-787
Although drying is widely applied during the manufacturing of solid dosage forms, its potential effect on the product’s (key) properties is often underestimated. Hence, the present study addresses drying related modifications of wet-extruded pellet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabec38d8b29ddde250a6304d53feb63
https://doi.org/10.1016/j.ijpharm.2014.12.030
https://doi.org/10.1016/j.ijpharm.2014.12.030
Autor:
Eva Roblegg, Simone Schrank, Klaus Nickisch, Gerold Koscher, Karin Eggenreich, Johannes Khinast
Publikováno v:
AIP Conference Proceedings.
Intravaginal rings (IVRs) are designed for controlled release of one or more active pharmaceutical ingredients (APIs) to the vaginal tract, and finally into systemic circulation over extended time periods [1]. The concept is built on the principle of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66fce58578ecec5d1fc800bb9032adda
https://doi.org/10.1063/1.5016734
https://doi.org/10.1063/1.5016734
Autor:
Eva Roblegg, Simone Schrank, Maximilian O. Besenhard, Johannes Khinast, Rafael Johannes-Paul Eder, Heidrun Gruber-Woelfler
Publikováno v:
Crystal Growth & Design. 12:4733-4738
A continuous tubular crystallizer system with an inner diameter of 2.0 mm and an overall length of 27 m was used to generate acetylsalicylic acid seeds in situ from ethanolic solution via cooling and ultrasound irradiation and to grow the crystals in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51a124f26616517c4129143e74b4a4f8
https://doi.org/10.1021/cg201567y
https://doi.org/10.1021/cg201567y
Autor:
Gerold Koscher, Johannes Khinast, G Steinbichler, Daniel Franz Treffer, H. R. Juster, Karin Eggenreich, Eva Roblegg, Simone Schrank, Stephan Laske, Sarah Windhab
Publikováno v:
International journal of pharmaceutics. 505(1-2)
The objective of the present study was to develop a one-step process for the production of tablets directly from primary powder by means of injection molding (IM), to create solid-dispersion based tablets. Fenofibrate was used as the model API, a pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbbae801511f3d13d5acb536e0904a25
https://pubmed.ncbi.nlm.nih.gov/27012981
https://pubmed.ncbi.nlm.nih.gov/27012981
Autor:
Johannes Khinast, Andrea Feichtinger, Eva Roblegg, Simone Schrank, Stefan Mohr, Nicole Jedinger
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 92
The objective of the present study was to investigate interactions between alcohol and hot-melt extruded pellets and the resulting drug release behavior. The pellets were composed of vegetable calcium stearate as matrix carrier and paracetamol or cod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6651815cd6979466afdb8b17969e2029
https://pubmed.ncbi.nlm.nih.gov/25733499
https://pubmed.ncbi.nlm.nih.gov/25733499
Autor:
Andreas Zimmer, Eva Roblegg, Simone Schrank, Benjamin J. Glasser, Eva-Maria Saurugger, Maike Windbergs, Johannes Khinast, Heike M. A. Ehmann, Oliver Werzer, Birthe Kann
Publikováno v:
Molecular pharmaceutics. 11(2)
Drying is a common pharmaceutical process, whose potential to alter the final drug properties—even at relatively low temperatures—is often neglected. The present study addresses the impact of drying at 20 and 50 °C on wet-extruded calcium steara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b78ac72ef7ebc5b0aa36c63281224d60
https://pubmed.ncbi.nlm.nih.gov/24400735
https://pubmed.ncbi.nlm.nih.gov/24400735
Autor:
Patrick Wahl, Ian C. Jones, Theresa Hörmann, Reinhardt-Karsten Mürb, Johannes Khinast, Daniel Markl, Daniel Franz Treffer, Eva Roblegg, Simone Schrank, Paul Cruise, Gerold Koscher
Publikováno v:
International journal of pharmaceutics. 466(1-2)
This work focuses on the implementation and application of an in-line particle measurement tool to monitor particle properties of hot-melt extruded pellets. A novel image analysis system (Eyecon) is used to analyze pellets with a size of approximatel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1b32615718ed4b1880ce0831eaf78c
https://pubmed.ncbi.nlm.nih.gov/24614578
https://pubmed.ncbi.nlm.nih.gov/24614578