Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands

Autor: Teija Parkkari, Ettore Novellino, Clementina Manera, Luciana Marinelli, Giuseppe Saccomanni, Simone Saguto, Marco Allarà, Marco Macchia, Agostino Bruno, Alessia Ligresti, Chiara Arena, Simone Bertini, Juha R. Savinainen, Vincenzo Di Marzo

Publikováno v: European journal of medicinal chemistry 90 (2014): 526–536. doi:10.1016/j.ejmech.2014.11.066
info:cnr-pdr/source/autori:Bertini S.; Parkkari T.; Savinainen J.R.; Arena C.; Saccomanni G.; Saguto S.; Ligresti A.; Allara M.; Bruno A.; Marinelli L.; Di Marzo V.; Novellino E.; Manera C.; Macchia M./titolo:Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands/doi:10.1016%2Fj.ejmech.2014.11.066/rivista:European journal of medicinal chemistry/anno:2014/pagina_da:526/pagina_a:536/intervallo_pagine:526–536/volume:90

The CB2 receptor is a therapeutic target of increasing importance for several diseases, including pain, inflammation, neurodegeneration, cancer and osteoporosis. While several compounds showing CB2-selective agonist or inverse agonist properties have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af40304bd7a3fe76c334f68b8dea7871
https://doi.org/10.1016/j.ejmech.2014.11.066