Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Simone S. Riedel"'
Autor:
Carina A. Bäuerlein, Musga Qureischi, Zeinab Mokhtari, Paula Tabares, Christian Brede, Ana-Laura Jordán Garrote, Simone S. Riedel, Martin Chopra, Simone Reu, Anja Mottok, Estibaliz Arellano-Viera, Carolin Graf, Miriam Kurzwart, Katharina Schmiedgen, Hermann Einsele, Matthias Wölfl, Paul-Gerhardt Schlegel, Andreas Beilhack
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Acute graft-versus-host disease (aGvHD) is a severe and often life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT). AGvHD is mediated by alloreactive donor T-cells targeting predominantly the gastrointestinal trac
Externí odkaz:
https://doaj.org/article/88450728038c452190d0abd979f290b8
Autor:
Etienne Danis, Taylor Yamauchi, Kristen Echanique, Xi Zhang, Jessica N. Haladyna, Simone S. Riedel, Nan Zhu, Huafeng Xie, Stuart H. Orkin, Scott A. Armstrong, Kathrin M. Bernt, Tobias Neff
Publikováno v:
Cell Reports, Vol 14, Iss 8, Pp 1953-1965 (2016)
Early T cell precursor acute lymphoblastic leukemia (ETP-ALL) is an aggressive subtype of ALL distinguished by stem-cell-associated and myeloid transcriptional programs. Inactivating alterations of Polycomb repressive complex 2 components are frequen
Externí odkaz:
https://doaj.org/article/1a481861ef994065bf3a95b20c803c62
Autor:
Huijuan Lin, Keren Cheng, Hiroshi Kubota, Yemin Lan, Simone S. Riedel, Kazue Kakiuchi, Kotaro Sasaki, Kathrin M. Bernt, Marisa S. Bartolomei, Mengcheng Luo, P. Jeremy Wang
Publikováno v:
Genes & Development. 36:752-763
Self-renewal of spermatogonial stem cells is vital to lifelong production of male gametes and thus fertility. However, the underlying mechanisms remain enigmatic. Here, we show that DOT1L, the sole H3K79 methyltransferase, is required for spermatogon
Autor:
Fatemeh Alikarami, Simone S. Riedel, Qinglan Li, Changya Chen, Taylor Yamauchi, Etienne Danis, Kai Tan, Liling Wan, Tobias Neff, Kathrin M. Bernt
Publikováno v:
Blood. 140:97-98
Autor:
Jessica Haladyna, Kathrin M. Bernt, Simone S. Riedel, Clara Libbrecht, Fatemeh Alikarami, Alexandra Lenard, Gerard M. McGeehan, Hongbo Xie, Patricia Ernst, Molly C. Kingsley
Publikováno v:
Leukemia
Translocations of Meningioma-1 (MN1) occur in a subset of acute myeloid leukemias (AML) and result in high expression of MN1, either as a full-length protein, or as a fusion protein that includes most of the N-terminus of MN1. High levels of MN1 corr
Autor:
Kathrin M. Bernt, Bo-Rui Chen, Hongbo Xie, Sally P. Stabler, Aniruddha J. Deshpande, Clara Libbrecht, Andrew M. Intlekofer, Madelyn K. Bollig, Molly C. Kingsley, Simone S. Riedel, Tyler Shank, Taylor Pastuer
Publikováno v:
Blood Adv
Understanding mechanisms of cooperation between oncogenes is critical for the development of novel therapies and rational combinations. Acute myeloid leukemia (AML) cells with KMT2A-fusions and KMT2A partial tandem duplications (KMT2APTD) are known t
Autor:
Simone S. Riedel, Alexandra Lenard, Nan Zhu, Taylor Pastuer, Molly C. Kingsley, Tobias Neff, Zuo-Fei Yuan, Tyler Shank, Clara Libbrecht, Hongbo Michael Xie, Kathrin M. Bernt
Publikováno v:
Exp Hematol
Inhibition of the H3K79 histone methyltransferase DOT1L has exhibited encouraging preclinical and early clinical activity in KMT2A (MLL)-rearranged leukemia, supporting the development of combinatorial therapies. Here, we investigated two novel combi
Autor:
Nan Zhu, Hongbo Michael Xie, Zuo-Fei Yuan, Simone S. Riedel, Alexandra Lenard, Tobias Neff, Kathrin M. Bernt
Inhibition of the histone methyl-transferase DOT1L (KMT4) has shown encouraging activity in preclinical models of KMT2A (MLL)-rearranged leukemia. The DOT1L inhibitor pinometostat (EPZ5676) was well tolerated in early phase clinical trials and showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e51e7644b434a40376e3bb33058292c
Autor:
Hongbo Xie, Simone S. Riedel, Daniel Tsai, Martin Carroll, Sara E. Meyer, Gerald Wertheim, Bryan Manning, Benjamin A. Garcia, Katarzyna Kulej, Pamela J. Sung, Kathrin M. Bernt, Simone Sidoli
Publikováno v:
Blood. 138:785-785
Internal tandem duplication mutations in the Fms-like tyrosine kinase 3 (FLT3-ITD) are frequently recurring in AML and confer a poor prognosis. FLT3 inhibitors (FLT3i) such as gilteritinib are efficacious in relapsed AML. Clinical responses to FLT3i
Autor:
Xi Zhang, Taylor Yamauchi, Jessica Haladyna, Stuart H. Orkin, Huafeng Xie, Nan Zhu, Scott A. Armstrong, Tobias Neff, Simone S. Riedel, Kathrin M. Bernt, Kristen Echanique, Etienne Danis
Publikováno v:
Cell reports
Cell Reports, Vol 14, Iss 8, Pp 1953-1965 (2016)
Cell Reports, Vol 14, Iss 8, Pp 1953-1965 (2016)
SUMMARY Early T cell precursor acute lymphoblastic leukemia (ETP-ALL) is an aggressive subtype of ALL distinguished by stem-cell-associated and myeloid transcriptional programs. Inactivating alterations of Polycomb repressive complex 2 components are