Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Simone Rothmiller"'
Autor:
Virginia Egea, Karina Lutterberg, Dirk Steinritz, Simone Rothmiller, Konrad Steinestel, Jan Caca, Andreas Nerlich, Helmut Blum, Sarah Reschke, Sajjad Khani, Alexander Bartelt, Franz Worek, Horst Thiermann, Christian Weber, Christian Ries
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-12 (2024)
Abstract Sulfur mustard (SM) is a highly toxic chemical warfare agent. Exposure to SM results in various pathologies including skin lesions with subsequent impaired wound healing. To date, there are no effective treatments available. Here we discover
Externí odkaz:
https://doaj.org/article/06210cd3488c496e91580c92cd6a7e1e
Publikováno v:
Cells, Vol 13, Iss 17, p 1449 (2024)
Background: Intracellular tracking is commonly used in trafficking research. Until today, the respective techniques have remained complex, and complicated, mostly transgenic target protein changes are necessary, often requiring expensive equipment an
Externí odkaz:
https://doaj.org/article/e96a6d49fe0249d28f2aa005dcc7ec6f
Autor:
Joanna Ruszkiewicz, Ylea Papatheodorou, Nathalie Jäck, Jasmin Melzig, Franziska Eble, Annika Pirker, Marius Thomann, Andreas Haberer, Simone Rothmiller, Alexander Bürkle, Aswin Mangerich
Publikováno v:
Cells, Vol 12, Iss 19, p 2396 (2023)
Sulfur mustard (SM) and its derivatives are potent genotoxic agents, which have been shown to trigger the activation of poly (ADP-ribose) polymerases (PARPs) and the depletion of their substrate, nicotinamide adenine dinucleotide (NAD+). NAD+ is an e
Externí odkaz:
https://doaj.org/article/87adbd4b66ac4918a03b77d49f2b9fed
Publikováno v:
Stem Cells International, Vol 2022 (2022)
Motor neurons (MNs) derived from human-induced pluripotent stem cells (hiPSC) hold great potential for the treatment of various motor neurodegenerative diseases as transplantations with a low-risk of rejection are made possible. There are many hiPSC
Externí odkaz:
https://doaj.org/article/cfaf7c1a59ee443b93f56272c5afdb00
Autor:
Wiebke Nadolni, Roland Immler, Kilian Hoelting, Marco Fraticelli, Myriam Ripphahn, Simone Rothmiller, Masayuki Matsushita, Ingrid Boekhoff, Thomas Gudermann, Markus Sperandio, Susanna Zierler
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
During inflammation, neutrophils are one of the first responding cells of innate immunity, contributing to a fast clearance of infection and return to homeostasis. However, excessive neutrophil infiltration accelerates unsolicited disproportionate in
Externí odkaz:
https://doaj.org/article/7c8ee04e5a11479d9b310f0f5b376134
Autor:
Gabriele Horn, Catherine Schäfers, Horst Thiermann, Sandra Völkl, Annette Schmidt, Simone Rothmiller
Publikováno v:
Archives of Toxicology. 96:3053-3066
Chronic wounds, skin blisters, and ulcers are the result of skin exposure to the alkylating agent sulfur mustard (SM). One potential pathomechanism is senescence, which causes permanent growth arrest with a pro-inflammatory environment and may be ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07792256288c40eb5e02d9848b2ee73e
https://doi.org/10.1007/s00204-022-03346-7
https://doi.org/10.1007/s00204-022-03346-7
Autor:
Harald John, Kai Kehe, Dirk Steinritz, Horst Thiermann, Markus Siegert, Simone Rothmiller, Thomas Gudermann, Andreas Kranawetvogl, Simon Lang, Annette M. Schmidt, Tanja Popp
Publikováno v:
Toxicology Letters. 314:172-180
Vesicants cause a multitude of cutaneous reactions like erythema, blisters and ulcerations. After exposure to sulfur mustard (SM) and related compounds, patients present dermal symptoms typically known for chemicals categorized as skin sensitizer (e.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f0641425687cf1f60627bd9888ab10
https://doi.org/10.1016/j.toxlet.2019.07.023
https://doi.org/10.1016/j.toxlet.2019.07.023
Autor:
Annette M. Schmidt, Hanns Leonhard Kaatsch, Matthias Port, Julia Jakobi, Harry Scherthan, Reinhard Ullmann, Simone Rothmiller, Benjamin Valentin Becker, Gerrit Schrock, Jessica Müller, Horst Thiermann, Richard Obermair
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 1146, p 1146 (2021)
Volume 22
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 1146, p 1146 (2021)
Sulfur mustard (SM) is a chemical warfare agent that can damage DNA via alkylation and oxidative stress. Because of its genotoxicity, SM is cancerogenic and the progenitor of many chemotherapeutics. Previously, we developed an SM-resistant cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9c52f0321a665dd5682bd76c5c66ef
Autor:
Niklas Jäger, Alexander Bürkle, Adrian Neu, Simone Rothmiller, Christoph Rummel, Thimo Meyer, Annette Schmidt, Aswin Mangerich, Horst Thiermann, Michael A. Scherer, Dirk Steinritz, Nicole Meier
Publikováno v:
Archives of Toxicology
Wound healing is a complex process, and disturbance of even a single mechanism can result in chronic ulcers developing after exposure to the alkylating agent sulfur mustard (SM). A possible contributor may be SM-induced chronic senescent mesenchymal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c34cbd8e5bda4ed3791b0079a45371f
https://pubmed.ncbi.nlm.nih.gov/33491125
https://pubmed.ncbi.nlm.nih.gov/33491125
Autor:
Horst Thiermann, Markus Wolf, Franz Worek, Simone Rothmiller, Annette Schmidt, Dirk Steinritz
Publikováno v:
Toxicology Letters. 293:16-20
Background The cell line HaCaT/SM was developed as a sulfur mustard (SM) resistant cell line from the human keratinocyte cell line HaCaT. This cell line was established to learn more about the effect of SM and possible therapeutic approaches to count
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920ecedcb2f82f0e82747a47f5811314
https://doi.org/10.1016/j.toxlet.2018.03.008
https://doi.org/10.1016/j.toxlet.2018.03.008