Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Simone Popp"'
Autor:
Patrizia Murer, Barbara Brannetti, Jean-Michel Rondeau, Laetitia Petersen, Nicole Egli, Simone Popp, Catherine Regnier, Kirsten Richter, Andreas Katopodis, Christoph Huber
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Novel engineered IL-2 agonists strive to increase the therapeutic window of aldesleukin (human IL-2) by increasing selectivity toward effector over regulatory T cells and reducing dose-limiting toxicities. Here we describe ANV419, an IL-2/anti-IL2 an
Externí odkaz:
https://doaj.org/article/c58320a3176c45a68cbb1b5dbf7c8122
Autor:
Thomas Calzascia, Gerhard Zenke, Roger Grau, Sabine Geisse, Seguinde Arora, Jiri Kovarik, Elodie Arduin, Torsten Kuiper, Paulo Roky Bamert, Simone Popp
Publikováno v:
Molecular Immunology. 63:456-463
The effects of the Fc silencing mutations such as leucine (L) to alanine (A) substitution at the position 234 and 235 (LALA) and the alanine (A) to asparagine (N) substitution at position 297 (N297A) are well investigated for human IgG. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d629bdbc2b231efcae0be059cbf519e6
https://doi.org/10.1016/j.molimm.2014.09.017
https://doi.org/10.1016/j.molimm.2014.09.017
Autor:
Carmen Barske, Anis Mir, Stefanie Joller, Katie A. Worringer, Dominik Feuerbach, Reiner Aichholz, Gaelle Elain, Irena Brzak, Laurent Klein, Patrick Schindler, Christopher J. Faraday, Chaoyang Ye, Ajamete Kaykas, Sravya Kommineni, Ulf P. Neumann, Nathalie George, Edwige Beng-Louka, Simone Popp, Daniel J. Ho, Karl Welzenbach
Publikováno v:
Neuroscience letters. 660
Triggering receptor expressed in myeloid cells (TREM2) is a member of the immunoglobulin superfamily and is expressed in macrophages, dendritic cells, microglia, and osteoclasts. TREM2 plays a role in phagocytosis, regulates release of cytokine, cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f09f20d5215d2435ef69431f2fcf4f3
https://pubmed.ncbi.nlm.nih.gov/28923481
https://pubmed.ncbi.nlm.nih.gov/28923481
Autor:
Karl Welzenbach, Anis Mir, Christine L. Hsieh, Reiner Aichholz, Gaelle Elain, Daniel J. Ho, Patrick Schindler, Carmen Barske, Mary C. Nakamura, Stefanie Joller, Christopher J. Faraday, Dominik Feuerbach, Chaoyang Ye, Ajamete Kaykas, Sravya Kommineni, Katie A. Worringer, Irena Brzak, Nathalie George, Ulf P. Neumann, Laurent Klein, Edwige Beng-Louka, Simone Popp
Triggering receptor expressed in myeloid cells (TREM2) is a member of the immunoglobulin superfamily and is expressed in macrophages, dendritic cells, microglia, and osteoclasts. TREM2 plays a role in phagocytosis, regulates release of cytokine, cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8000622f0b3046fcbf61f2a9f56dbf72
https://doi.org/10.1101/133751
https://doi.org/10.1101/133751
Autor:
Jiri Kovarik, Onur Boyman, Thomas Calzascia, Andreas Katopodis, Janine Woytschak, Lukas Sommer, Catherine H. Régnier, Chao Zou, Daniel Zingg, Gerhard Zenke, Simone Popp, Barbara Brannetti, Emmanuelle Wirth, Natalia Arenas-Ramirez
Publikováno v:
Sci Transl Med
Science Translational Medicine
Science Translational Medicine
Interleukin-2 (IL-2) immunotherapy is an attractive approach in treating advanced cancer. However, by binding to its IL-2 receptor α (CD25) subunit, IL-2 exerts unwanted effects, including stimulation of immunosuppressive regulatory T cells (Tregs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368dced5e550799aa528deaf8ef3ead0