Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Simone Polvani"'
Autor:
Laura Naldi, Benedetta Fibbi, Simone Polvani, Chiara Cirillo, Francesca Pasella, Francesca Bartolini, Francesca Romano, Alessandra Fanelli, Alessandro Peri, Giada Marroncini
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8402 (2024)
We have previously demonstrated that the vasopressin type 2 receptor (AVPR2) antagonist tolvaptan reduces cell proliferation and invasion and triggers apoptosis in different human cancer cell lines. To study this effect in vivo, a xenograft model of
Externí odkaz:
https://doaj.org/article/9d897f7f586c42e7be8b150a6caf97f2
Autor:
Daniele Lavacchi, Simone Polvani, Antonio Taddei, Federico Scolari, Luca Messerini, Enrico Caliman, Luca Moraldi, Alessia Guidolin, Gian Luca Grazi, Andrea Galli, Serena Pillozzi, Lorenzo Antonuzzo
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionPancreatic adenocarcinoma (PC) is one of the most lethal malignancies; even after resection the patients’ 5-year disease-free survival (DFS) is lower than 26%. The genetic mutational landscape of PC is dominated by activating KRAS mutat
Externí odkaz:
https://doaj.org/article/efcffb8b6c89433990e68a34e3066f61
Autor:
Giada Marroncini, Laura Naldi, Benedetta Fibbi, Alice Errico, Simone Polvani, Marco Brogi, Alessandra Fanelli, Mario Maggi, Alessandro Peri
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16680 (2023)
In cancer patients, hyponatremia is detected in about 40% of cases at hospital admission and has been associated to a worse outcome. We have previously observed that cancer cells from different tissues show a significantly increased proliferation rat
Externí odkaz:
https://doaj.org/article/fecb9186de5e44449a5889893792e29a
Publikováno v:
Cells, Vol 9, Iss 1, p 101 (2019)
The nuclear receptors (NRs) belong to a vast family of evolutionary conserved proteins acting as ligand-activated transcription factors. Functionally, NRs are essential in embryogenesis and organogenesis and in adulthood they are involved in almost e
Externí odkaz:
https://doaj.org/article/4160e19d7e4140e290fcd06ca039f2eb
Autor:
Filippo Cellai, Armelle Munnia, Jessica Viti, Saer Doumett, Costanza Ravagli, Elisabetta Ceni, Tommaso Mello, Simone Polvani, Roger W. Giese, Giovanni Baldi, Andrea Galli, Marco E. M. Peluso
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 5, p 939 (2017)
Nanotechnology is addressing major urgent needs for cancer treatment. We conducted a study to compare the frequency of 3-(2-deoxy-β-d-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M1dG) and 8-oxo-7,8-dihydro-2′-deoxyguano
Externí odkaz:
https://doaj.org/article/b9ee8b5549e048f391563d945c210fb1
Publikováno v:
PPAR Research, Vol 2012 (2012)
Peroxisome-proliferator activator receptor γ (PPARγ) is a nuclear receptor of central importance in energy homeostasis and inflammation. Recent experimental pieces of evidence demonstrate that PPARγ is implicated in the oxidative stress response,
Externí odkaz:
https://doaj.org/article/f0121c5f96204fb5aeeccf3505af353d
Publikováno v:
PPAR Research, Vol 2009 (2009)
A growing number of new studies demonstrate that nuclear receptors are involved in the development of alcoholic liver disease (ALD). Ethanol metabolism and RXR/PPAR functions are tightly interconnected in the liver. Several ethanol metabolizing enzym
Externí odkaz:
https://doaj.org/article/0bb1c49b05de4c43aeb30fca2ea8e28f
Autor:
Simone Polvani, Filippo Martignano, Guido Scoccianti, Adriano Pasqui, Anna Rita Palomba, Silvo Conticello, Andrea Galli, Ilaria Palchetti, Chiara Caporalini, Lorenzo Antonuzzo, Domenico Andrea Campanacci, Serena Pillozzi
Publikováno v:
Anti-Cancer Drugs. 33:278-285
Osteosarcoma is the most common primary malignant bone tumour in children and teenagers, and it is characterised by drug resistance and high metastatic potential. Increasing studies have highlighted the critical roles of long noncoding RNAs (lncRNAs)
Autor:
Simone Polvani, Sara Pepe, Sara Tempesti, Mirko Tarocchi, Giada Marroncini, Lapo Bencini, Elisabetta Ceni, Tommaso Mello, Lucia Picariello, Irene Simeone, Cecilia Grappone, Gabriele Dragoni, Lorenzo Antonuzzo, Elisa Giommoni, Stefano Milani, Andrea Galli
Publikováno v:
International Journal of Oncology. 60
The expression of the nuclear receptor transcription factor (TF) COUP‑TFII is broadly associated with cell differentiation and cancer development, including of pancreatic ductal adenocarcinoma (PDAC), a devastating disease with one of the poorest p
Autor:
Alice Guida, Irene Simeone, Simone Polvani, Elisabetta Ceni, Lucia Picariello, Gabriele Dragoni, Andrea Galli, Tommaso Mello
Publikováno v:
Journal of Hepatology. 77:S659