Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Simone Petersen"'
Autor:
Iver Petersen, Simone Petersen
Publikováno v:
Analytical Cellular Pathology, Vol 22, Iss 3, Pp 111-121 (2001)
Lung cancer is a highly aggressive neoplasm which is reflected by a multitude of genetic aberrations being detectable on the chromosomal and molecular level. In order to understand this seemingly genetic chaos, we performed Comparative Genomic Hybrid
Externí odkaz:
https://doaj.org/article/6b347778f4fa4631a7d6e196fddedd31
Autor:
Carsten Denkert, Karsten Schlüns, Angela Reles, Iver Petersen, Manfred Dietel, Simone Petersen, Steffen Hauptmann, Ines Koch
Publikováno v:
Human Pathology. 33:632-641
The genetic changes involved in the pathogenesis of ovarian carcinoma are not completely understood. To investigate this matter, we studied paraffin-embedded, microdissected tissue of 47 ovarian epithelial tumors (9 adenomas, 11 tumors of low maligna
Autor:
Bernardo Reina-San-Martin, Alexandru Olaru, R. Daniel Camerini-Otero, Katia Manova, Duane R. Pilch, Oscar Fernandez-Capetillo, Michel C. Nussenzweig, Michael Eckhaus, Christophe E. Redon, Michael J. Difilippantonio, William M. Bonner, Olga A. Sedelnikova, Hua Tang Chen, Simone Petersen, Ferenc Livak, Vincenzo Coppola, Peter J. Romanienko, Arkady Celeste, Eric Meffre, Lino Tessarollo, André Nussenzweig
Publikováno v:
Science. 296:922-927
Higher order chromatin structure presents a barrier to the recognition and repair of DNA damage. Double-strand breaks (DSBs) induce histone H2AX phosphorylation, which is associated with the recruitment of repair factors to damaged DNA. To help clari
Autor:
Christophe E. Redon, Leif Hanitsch, Patrick C. Wilson, Masamichi Muramatsu, Bernardo Reina-San-Martin, Rafael Casellas, Thomas Ried, Michael J. Difilippantonio, Tasuku Honjo, Hua Tang Chen, Arkady Celeste, William M. Bonner, Simone Petersen, Duane R. Pilch, Michel C. Nussenzweig, André Nussenzweig
Publikováno v:
Nature. 414:660-665
Class switch recombination (CSR) is a region-specific DNA recombination reaction that replaces one immunoglobulin heavy-chain constant region (Ch) gene with another. This enables a single variable (V) region gene to be used in conjunction with differ
Autor:
Almut Goeze, Karsten Schlüns, Simone Petersen, Zsuzsanna Thäsler, Guenter Wolf, Iver Petersen
Publikováno v:
The Journal of Pathology. 196:8-16
Comparative genomic hybridization (CGH) was used to screen 83 lung adenocarcinomas of 60 patients for chromosomal imbalances. The most common alteration was DNA overrepresentation on chromosome 1q, with a peak incidence at 1q22–q23 in 73% of the pr
Publikováno v:
The American Journal of Pathology. 157:369-375
Chromosomal imbalances in 113 primary head and neck squamous cell carcinomas (HNSCCs) determined by comparative genomic hybridization were correlated with patients survival using custom-made computer software which enabled the assessment of individua
Autor:
Michael R. Speicher, Iver Petersen, Christine Fauth, Isabell Jentsch, Simone Petersen, Roland Eils, Sabine Uhrig
Publikováno v:
Laboratory Investigation. 80:1031-1041
Lung cancer has a considerable impact on morbidity and mortality throughout the world. Despite extensive effort, no lung cancer-specific cytogenetic changes, such as lineage-specific translocations or inversions, have been described to date. In this
Autor:
Reinhold Schäfer, Manfred Dietel, Iver Petersen, Simone Petersen, Jacqueline Rudolf, Karsten Schlüns, Oleg I. Tchernitsa, Cordula Heckert
Publikováno v:
International Journal of Cancer. 86:512-517
Lung cancer is a highly aggressive neoplasm with 85% mortality. To identify new tumor-associated genes, we compared the expression profile of a primary metastasizing adenocarcinoma with normal airway epithelial cells. Two cDNA libraries of up- and do
Publikováno v:
Neurosurgical Focus. 8:1-6
Object The authors investigated the spectrum of chromosomal imbalances of pilocytic astrocytoma by using comparative genomic hybridization (CGH). Methods Tumor DNA was extracted from surgically obtained samples of 18 pilocytic astrocytomas that were
Autor:
Iver Petersen, Jacqueline Rudolf, Manfred Dietel, Ulrike Bockmühl, Simone Petersen, Nicole Deutschmann
Publikováno v:
International Journal of Cancer. 88:71-76
Loss of chromosome 10q is a critical step during the progression and metastasis formation of lung cancer. We recently defined 3 distinct regions of allelic imbalances and considered the DMBT1 gene at 10q25-q26 an interesting candidate for the most te