Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Simone P. Zehntner"'
Autor:
Metin Yesiltepe, Tao Yin, Marc D. Tambini, Lionel Breuillaud, Simone P. Zehntner, Luciano D’Adamio
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Cleavage of Amyloid precursor protein by β- and γ-secretases lead to Aβ formation. The widely accepted pathogenic model states that these mutations cause AD via an increase in Aβ formation and accumulation of Aβ in Amyloid plaques. APP mutations
Externí odkaz:
https://doaj.org/article/f9500c3c37b143f7b8aafee7a137c7d5
Autor:
Marilyn Grand'Maison, Simone P. Zehntner, Ming-Kai Ho, François Hébert, Andrew Wood, Felix Carbonell, Alex P. Zijdenbos, Edith Hamel, Barry J. Bedell
Publikováno v:
Neurobiology of Disease, Vol 54, Iss , Pp 59-67 (2013)
Magnetic resonance imaging (MRI) studies have identified aberrant cortical structure in Alzheimer's disease (AD). The association between MRI-derived cortical morphometry measures and β-amyloid, however, remains poorly understood. In this study, we
Externí odkaz:
https://doaj.org/article/5bb645cbe13047059ff61182188accf3
Autor:
Bernard Massie, Josephine Nalbantoglu, Anne-Marie Mes-Masson, Geneviève Lavoie, Simone P. Zehntner, Zafiro Koty, Jairo Jaime, Cara Jean Lau, Denis Bourbeau
Gene therapy is a promising approach for cancer treatment; however, efficacy of current vectors remains insufficient. To improve the success of suicide gene therapy, we constructed a replication-competent adenoviral vector that has its protease gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a22bace3f3b41bb85cdeb683005f794
https://doi.org/10.1158/0008-5472.c.6496322.v1
https://doi.org/10.1158/0008-5472.c.6496322.v1
Autor:
Bernard Massie, Josephine Nalbantoglu, Anne-Marie Mes-Masson, Geneviève Lavoie, Simone P. Zehntner, Zafiro Koty, Jairo Jaime, Cara Jean Lau, Denis Bourbeau
Supplementary Figure 1 from Improvement of Antitumor Activity by Gene Amplification with a Replicating but Nondisseminating Adenovirus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c0a4332c1b6259cd51c91dc2fb4a3e
https://doi.org/10.1158/0008-5472.22370240.v1
https://doi.org/10.1158/0008-5472.22370240.v1
Autor:
Bernard Massie, Josephine Nalbantoglu, Anne-Marie Mes-Masson, Geneviève Lavoie, Simone P. Zehntner, Zafiro Koty, Jairo Jaime, Cara Jean Lau, Denis Bourbeau
Supplementary Table 1 from Improvement of Antitumor Activity by Gene Amplification with a Replicating but Nondisseminating Adenovirus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006371d636d8738c19999a62b194f007
https://doi.org/10.1158/0008-5472.22370237
https://doi.org/10.1158/0008-5472.22370237
Autor:
Marc D. Tambini, Tao Yin, Metin Yesiltepe, Lionel Breuillaud, Simone P. Zehntner, Luciano D'Adamio
Background While most Alzheimer’s disease cases are sporadic with late onset (LOAD), ~ 2% of cases are inherited, have an early onset, and are caused by mutations in Presenilins (PSEN1/2) or Amyloid-β Precursor Protein (APP) genes (familial AD, FA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37fe0a4a21e57eb489fef8087ca0b3f6
https://doi.org/10.21203/rs.3.rs-2272441/v1
https://doi.org/10.21203/rs.3.rs-2272441/v1
Autor:
Marc D. Tambini, Tao Yin, Metin Yesiltepe, Lionel Breuillaud, Simone P. Zehntner, Cristina d’Abramo, Luca Giliberto, Luciano D’Adamio
Publikováno v:
Journal of Biological Chemistry. :104868
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52beece5d723b968d18c274ff62abfd3
https://doi.org/10.1016/j.jbc.2023.104868
https://doi.org/10.1016/j.jbc.2023.104868
Autor:
Simone P. Zehntner, Kelly A Norris, Luciano D'Adamio, Lionel Breuillaud, Siqiang Ren, Tao Yin, Wen Yao
Trem2R47H rats, which carry the Alzheimer’s disease (AD) risk factor p.R47H variant of the microglia gene TREM2 and produce human Aβ. Previously, we demonstrated that supraphysiological TNF-α boost glutamatergic transmission and suppresses Long-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9754c309237138679b3fb477df4c1d5
https://doi.org/10.1101/2020.08.20.256099
https://doi.org/10.1101/2020.08.20.256099
Autor:
Hugo Théoret, Colleen Manitt, Simone P. Zehntner, Ridha Joober, Conrad Eng, Chawki Benkelfat, Guy A. Rouleau, Kristina DeDuck, Yu Zhang, Barry J. Bedell, Aurore Menegaux, Amanda Chalupa, Daniel E. Vosberg, Marco Leyton, Cecilia Flores, Dominique Allard, Alain Dagher, Myriam Srour, Franco Lepore
Publikováno v:
The Journal of Neuroscience. 38:4655-4665
The axon guidance cue receptor DCC (deleted in colorectal cancer) plays a critical role in the organization of mesocorticolimbic pathways in rodents. To investigate whether this occurs in humans, we measured (1) anatomical connectivity between the su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa8ccb3fc094776cc2bea90f5e0eab40
https://doi.org/10.1523/jneurosci.3251-17.2018
https://doi.org/10.1523/jneurosci.3251-17.2018
Autor:
Kelly A Norris, Tao Yin, Lionel Breuillaud, Siqiang Ren, Wen Yao, Luciano D'Adamio, Simone P. Zehntner
Publikováno v:
Journal of Biological Chemistry. 296:100089
Alzheimer's disease (AD) is a neurodegenerative dementia associated with deposition of amyloid plaques and neurofibrillary tangles, formed by amyloid β (Aβ) peptides and phosphor-tau, respectively, in the central nervous system. Approximately 2% of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39ef228fed47aecd923a12de63285a2f
https://doi.org/10.1074/jbc.ra120.016395
https://doi.org/10.1074/jbc.ra120.016395