Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Simone Oppenheimer"'
Autor:
Jinqi Liu, Joshua Curtin, Dan You, Stephen Hillerman, Bifang Li-Wang, Rukiye Eraslan, Jenny Xie, Jesse Swanson, Ching-Ping Ho, Simone Oppenheimer, Bethanne M Warrack, Colleen A McNaney, David M Nelson, Jordan Blum, Taeg Kim, Mark Fereshteh, Michael Reily, Petia Shipkova, Anwar Murtaza, Miguel Sanjuan, John T Hunt, Luisa Salter-Cid
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0212670 (2019)
Immunotherapy has fundamentally changed the landscape of cancer treatment. Despite the encouraging results with the checkpoint modulators, response rates vary widely across tumor types, with a majority of patients exhibiting either primary resistance
Externí odkaz:
https://doaj.org/article/7604dc75ad594b68a709196c2f123df0
Autor:
Chiang Yu, Gregory Vite, Simone Oppenheimer, Derek Norris, Harold Malone, Anne Lewin, Daniel Kukral, Bala Krishnan, John T. Hunt, Christine Hilt, Benjamin Henley, Amy Hammell, Ashvinikumar Gavai, Brian Fink, Joseph Fargnoli, Craig Fairchild, Stuart Emanuel, Francis Y. Lee, Tai W. Wong
Supplementary Tables 1-3, Figure Legends 1-6 from Antitumor and Antiangiogenic Activities of BMS-690514, an Inhibitor of Human EGF and VEGF Receptor Kinase Families
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f909ef46a03d1570a27d99c5261e2b
https://doi.org/10.1158/1078-0432.22441917.v1
https://doi.org/10.1158/1078-0432.22441917.v1
Autor:
Chiang Yu, Gregory Vite, Simone Oppenheimer, Derek Norris, Harold Malone, Anne Lewin, Daniel Kukral, Bala Krishnan, John T. Hunt, Christine Hilt, Benjamin Henley, Amy Hammell, Ashvinikumar Gavai, Brian Fink, Joseph Fargnoli, Craig Fairchild, Stuart Emanuel, Francis Y. Lee, Tai W. Wong
Purpose: The extensive involvement of the HER kinases in epithelial cancer suggests that kinase inhibitors targeting this receptor family have the potential for broad spectrum antitumor activity. BMS-690514 potently inhibits all three HER kinases, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33f1ae66761ffc51c82294bcb244134
https://doi.org/10.1158/1078-0432.c.6518787
https://doi.org/10.1158/1078-0432.c.6518787
Autor:
Chiang Yu, Gregory Vite, Simone Oppenheimer, Derek Norris, Harold Malone, Anne Lewin, Daniel Kukral, Bala Krishnan, John T. Hunt, Christine Hilt, Benjamin Henley, Amy Hammell, Ashvinikumar Gavai, Brian Fink, Joseph Fargnoli, Craig Fairchild, Stuart Emanuel, Francis Y. Lee, Tai W. Wong
Supplementary Figures 1-6 from Antitumor and Antiangiogenic Activities of BMS-690514, an Inhibitor of Human EGF and VEGF Receptor Kinase Families
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10077e61e239f1a813c40834f158a23d
https://doi.org/10.1158/1078-0432.22441920
https://doi.org/10.1158/1078-0432.22441920
Autor:
Joshua C. Curtin, Stephen Hillerman, Rukiye Eraslan, Jinqi Liu, Dan You, Bifang Li-Wang, Taeg Kim, Anwar Murtaza, John T. Hunt, David M. Nelson, Jesse Swanson, Jordan Blum, Mark Fereshteh, Michael D. Reily, Petia Shipkova, Jenny Xie, Bethanne M. Warrack, Luisa Salter-Cid, Colleen A. McNaney, Simone Oppenheimer, Miguel Sanjuan, Ching-Ping Ho
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0212670 (2019)
PLoS ONE
PLoS ONE
Immunotherapy has fundamentally changed the landscape of cancer treatment. Despite the encouraging results with the checkpoint modulators, response rates vary widely across tumor types, with a majority of patients exhibiting either primary resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccd2972f9b8159008a872a7d2c5b24b
https://doaj.org/article/7604dc75ad594b68a709196c2f123df0
https://doaj.org/article/7604dc75ad594b68a709196c2f123df0
Autor:
Hongjian Zhang, Brian E. Fink, David R. Langley, Harold Mastalerz, Ming Chang, Punit Marathe, Simone Oppenheimer, Dolatrai M. Vyas, Ping Chen, Bogdan Sleczka, John S. Tokarski, Francis Y. Lee, Kenneth J. Leavitt, Johnson Walter Lewis, Wen-Ching Han, Tai W. Wong, Ashvinikumar V. Gavai, Guifen Zhang, Henry Wong, Gregory D. Vite, Tarrant James G, Derek J. Norris
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4947-4954
Pyrrolotriazine dual EGFR/HER2 kinase inhibitors with a 5-((4-aminopiperidin-1-yl)methyl) solubilizing group were found to be superior to analogs with previously reported C-5 solubilizing groups. New synthetic methodology was developed for the parall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021672493e2ee4914b09e6b283807847
https://doi.org/10.1016/j.bmcl.2007.06.019
https://doi.org/10.1016/j.bmcl.2007.06.019
Autor:
Pierre Dextraze, Gregory D. Vite, Arvind Mathur, Ashvinikumar V. Gavai, Simone Oppenheimer, Ping Chen, John S. Tokarski, Tai W. Wong, Francis Y. Lee, Harold Mastalerz, Henry Wong, Wen-Ching Han, Johnson Walter Lewis, Guifen Zhang, David R. Langley, Brian E. Fink, Tarrant James G, Ming Chang, Hongjian Zhang, Bindu Goyal, Ruediger Edward H, Punit Marathe, Dolatrai M. Vyas
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2036-2042
Novel C-5 substituted pyrrolotriazines were optimized for dual EGFR and HER2 protein tyrosine kinase inhibition. The lead compound exhibited promising oral efficacy in both EGFR and HER2 driven human tumor xenograft models. It is hypothesized that it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f7fe050dcf04e1a5b65d955bad651c
https://doi.org/10.1016/j.bmcl.2007.01.002
https://doi.org/10.1016/j.bmcl.2007.01.002
Autor:
Dan You, Simone Oppenheimer, Brian E. Fink, Francis Y.F. Lee, Kristen A. Kellar, Bruce Rowley, Rolf P. Ryseck, Ching Ping Ho, David Bol, Chiang Yu, Mei-Li Wen, Matthew V. Lorenzi, Tai W. Wong, Gregory D. Vite
Publikováno v:
Molecular Cancer Therapeutics. 5:1571-1576
Receptor tyrosine kinases (RTK) remain an area of therapeutic interest because of their role in epithelial tumors, and experimental models specific to these targets are highly desirable. Chimeric receptors were prepared by in-frame fusion of the CD8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fb27ea3060c91c3d6561d069291438
https://doi.org/10.1158/1535-7163.mct-06-0078
https://doi.org/10.1158/1535-7163.mct-06-0078
Autor:
Simone Oppenheimer, Hans Georg Simon
Publikováno v:
Gene. 172:175-181
In an effort to make mRNA differential display more amenable as a molecular screen, we have optimized the technology for the isotopic and non-isotopic detection of differentially regulated mRNAs. The number of amplification rounds in the displays was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03dbf286d247edc0d82fadd0d127e9a8
https://doi.org/10.1016/0378-1119(96)00015-7
https://doi.org/10.1016/0378-1119(96)00015-7
Autor:
Benjamin J. Henley, Bala Krishnan, Amy Hammell, Daniel W. Kukral, John T. Hunt, Joseph Fargnoli, Brian E. Fink, Derek J. Norris, Francis Y.F. Lee, Chiang Yu, Tai Wai Wong, Christine Hilt, Gregory D. Vite, Harold Malone, Ashvinikumar V. Gavai, Craig R. Fairchild, Stuart Emanuel, Anne Lewin, Simone Oppenheimer
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 17(12)
Purpose: The extensive involvement of the HER kinases in epithelial cancer suggests that kinase inhibitors targeting this receptor family have the potential for broad spectrum antitumor activity. BMS-690514 potently inhibits all three HER kinases, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed26ca579d69e34744c5ad7d9bdc97f2
https://pubmed.ncbi.nlm.nih.gov/21531814
https://pubmed.ncbi.nlm.nih.gov/21531814