Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Simone Nenci"'
Autor:
Marco W. Fraaije, Simone Nenci, Andrea Mattevi, Marta Ceccon, Elvira Romero, Francesca Magnani, Elisa Millana Fananas
Publikováno v:
Proceedings of the National Academy of Science of the United States of America, 114(26), 6764-6769. NATL ACAD SCIENCES
NADPH oxidases (NOXs) are the only enzymes exclusively dedicated to reactive oxygen species (ROS) generation. Dysregulation of these polytopic membrane proteins impacts the redox signaling cascades that control cell proliferation and death. We descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0ab45317d0bc95faf3aff3453a907f
https://doi.org/10.1073/pnas.1702293114
https://doi.org/10.1073/pnas.1702293114
Publikováno v:
Biochemical and Biophysical Research Communications
Although the precise functions of ether phospholipids are still poorly understood, significant alterations in their physiological levels are associated either to inherited disorders or to aggressive metastatic cancer. The essential precursor, alkyl-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce047cc8936189d14b496a597005e49d
http://europepmc.org/articles/PMC5146282
http://europepmc.org/articles/PMC5146282
Autor:
Daniel I. Benjamin, Alessandro Aliverti, Antonello Mai, Sergio Valente, Biagina Marrocco, Daniel K. Nomura, Andrea Mattevi, Simone Nenci, Valentina Piano
Publikováno v:
ACS Chemical Biology. 10:2589-2597
Dysregulated ether lipid metabolism is an important hallmark of cancer cells. Previous studies have reported that lowering ether lipid levels by genetic ablation of the ether lipid-generating enzyme alkyl-glycerone phosphate synthase (AGPS) lowers ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25992b99c5ed850c915b52602a71f75
https://doi.org/10.1021/acschembio.5b00466
https://doi.org/10.1021/acschembio.5b00466
Autor:
Albert J. R. Heck, Andrea Mattevi, Alessandro Aliverti, V. Pandini, Sara Rosati, Valentina Piano, Marco W. Fraaije, Simone Nenci, Dale E. Edmondson
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 109(46), 18791-18796. NATL ACAD SCIENCES
The precursor of the essential ether phospholipids is synthesized by a peroxisomal enzyme that uses a flavin cofactor to catalyze a reaction that does not alter the redox state of the substrates. The enzyme crystal structure reveals a V-shaped active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8bed5d86bd5e10d3c71202488561d4
https://doi.org/10.1073/pnas.1215128109
https://doi.org/10.1073/pnas.1215128109
Autor:
Silvia Buroni, Henrieta Škovierová, Elisabetta Molteni, Giovanna Riccardi, Florence Pojer, Claudia Trefzer, Vadim Makarov, Stewart T. Cole, Adela Bobovská, Simone Nenci, Katarína Mikušová, Kai Johnsson, Maria Rosalia Pasca
Publikováno v:
Journal of the American Chemical Society; Vol 134
Benzothiazinones (BTZs) are antituberculosis drug candidates with nanomolar bactericidal activity against tubercle bacilli. Here we demonstrate that BTZs are suicide substrates of the FAD-dependent decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase Dp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed48cf8d81ce98ec1b431a3aeef0dbc
Autor:
Anselmo Canciani, Antonella Chiapparino, Simone Nenci, Paolo Gabrieli, Salvatore R. Guarino, Matteo Campioni, Martina Palamini, Giuseppe Ciossani, Francesca Magnani, Federico Forneris
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 73:C1276-C1276
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::381e624d51bf2e4f75772192dff2131d
https://doi.org/10.1107/s2053273317082985
https://doi.org/10.1107/s2053273317082985
Autor:
Andrea Mattevi, Bruno Coutard, Julia Barthel, Jacques Rohayem, Simone Nenci, Victor B. Luzhkov, Ivonne Robel, Daniele Bonivento, Bruno Canard, Silvia Speroni
Publikováno v:
Journal of molecular biology. 387(5)
Astroviruses are single-stranded RNA viruses with a replication strategy based on the proteolytic processing of a polyprotein precursor and subsequent release of the viral enzymes of replication. So far, the catalytic properties of the astrovirus pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126f25b821b858833d31ef2f53bd0203
https://pubmed.ncbi.nlm.nih.gov/19249313
https://pubmed.ncbi.nlm.nih.gov/19249313