Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Simone Mosole"'
Autor:
Alessia Cacciatore, Dheeraj Shinde, Carola Musumeci, Giada Sandrini, Luca Guarrera, Domenico Albino, Gianluca Civenni, Elisa Storelli, Simone Mosole, Elisa Federici, Alessio Fusina, Marta Iozzo, Andrea Rinaldi, Matteo Pecoraro, Roger Geiger, Marco Bolis, Carlo V. Catapano, Giuseppina M. Carbone
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Castration-resistant prostate cancer (CRPC) is a frequently occurring disease with adverse clinical outcomes and limited therapeutic options. Here, we identify methionine adenosyltransferase 2a (MAT2A) as a critical driver of the androgen-in
Externí odkaz:
https://doaj.org/article/724f72ec506f4c06aa1670dd1c8ab69a
Autor:
Ryan M. Walsh, Raffaele Luongo, Elisa Giacomelli, Gabriele Ciceri, Chelsea Rittenhouse, Antonietta Verrillo, Maura Galimberti, Vittoria Dickinson Bocchi, Youjun Wu, Nan Xu, Simone Mosole, James Muller, Elena Vezzoli, Johannes Jungverdorben, Ting Zhou, Roger A. Barker, Elena Cattaneo, Lorenz Studer, Arianna Baggiolini
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114031- (2024)
Summary: Outer radial glia (oRG) emerge as cortical progenitor cells that support the development of an enlarged outer subventricular zone (oSVZ) and the expansion of the neocortex. The in vitro generation of oRG is essential to investigate the under
Externí odkaz:
https://doaj.org/article/1bf423d6421944a39056287be8845aa4
Autor:
Rydell Alvarez-Arzola, Nicoló Bancaro, Ping Lai, Giuseppe Attanasio, Laura Pellegrini, Martina Troiani, Manuel Colucci, Simone Mosole, Emiliano Pasquini, Andrea Alimonti, Circe Mesa
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Androgen deprivation therapy (ADT) is a standard therapy for prostate cancer (PCa). Though disseminated disease is initially sensitive to ADT, an important fraction of the patients progresses to castration-resistant prostate cancer (CRPC). F
Externí odkaz:
https://doaj.org/article/09b585dd6d844af980b3fa3079b072be
Autor:
Evangelia Lekka, Aleksandra Kokanovic, Simone Mosole, Gianluca Civenni, Sandro Schmidli, Artur Laski, Alice Ghidini, Pavithra Iyer, Christian Berk, Alok Behera, Carlo V. Catapano, Jonathan Hall
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The Lin28/let-7 axis regulates metabolic pathways in normal and pathological contexts. Here the authors show that pharmacological inhibition of Lin28 protects against lipid accumulation in multiple preclinical models of nonalcoholic fatty liver disea
Externí odkaz:
https://doaj.org/article/4eb77299f3fe4991b4cc526dc0ff726c
Autor:
Martina Troiani, Manuel Colucci, Mariantonietta D’Ambrosio, Ilaria Guccini, Emiliano Pasquini, Angelica Varesi, Aurora Valdata, Simone Mosole, Ajinkya Revandkar, Giuseppe Attanasio, Andrea Rinaldi, Anna Rinaldi, Marco Bolis, Pietro Cippà, Andrea Alimonti
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Abstract Cells subjected to treatment with anti-cancer therapies can evade apoptosis through cellular senescence. Persistent senescent tumor cells remain metabolically active, possess a secretory phenotype, and can promote tumor proliferation and met
Externí odkaz:
https://doaj.org/article/c5129a2c73bf496996067c83544c9029
Autor:
Marco Bolis, Daniela Bossi, Arianna Vallerga, Valentina Ceserani, Manuela Cavalli, Daniela Impellizzieri, Laura Di Rito, Eugenio Zoni, Simone Mosole, Angela Rita Elia, Andrea Rinaldi, Ricardo Pereira Mestre, Eugenia D’Antonio, Matteo Ferrari, Flavio Stoffel, Fernando Jermini, Silke Gillessen, Lukas Bubendorf, Peter Schraml, Arianna Calcinotto, Eva Corey, Holger Moch, Martin Spahn, George Thalmann, Marianna Kruithof-de Julio, Mark A. Rubin, Jean-Philippe P. Theurillat
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Transcriptional changes during prostate cancer progression are not yet fully understood. Here, the authors integrate a transcriptomics atlas of prostate cancer and validate it with preclinical models and single-cell RNA-seq, revealing the role of EZH
Externí odkaz:
https://doaj.org/article/6a080edb8c7340f18674ce8c5a8eaff3
Autor:
Martina Troiani, Manuel Colucci, Mariantonietta D’Ambrosio, Ilaria Guccini, Emiliano Pasquini, Angelica Varesi, Aurora Valdata, Simone Mosole, Ajinkya Revandkar, Giuseppe Attanasio, Andrea Rinaldi, Anna Rinaldi, Marco Bolis, Pietro Cippà, Andrea Alimonti
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/f6425f31869a4c14b0bd184a4c42baaf
Autor:
Tiziano Bernasocchi, Geniver El Tekle, Marco Bolis, Azzurra Mutti, Arianna Vallerga, Laura P. Brandt, Filippo Spriano, Tanya Svinkina, Marita Zoma, Valentina Ceserani, Anna Rinaldi, Hana Janouskova, Daniela Bossi, Manuela Cavalli, Simone Mosole, Roger Geiger, Ze Dong, Cai-Guang Yang, Domenico Albino, Andrea Rinaldi, Peter Schraml, Simon Linder, Giuseppina M. Carbone, Andrea Alimonti, Francesco Bertoni, Holger Moch, Steven A. Carr, Wilbert Zwart, Marianna Kruithof-de Julio, Mark A. Rubin, Namrata D. Udeshi, Jean-Philippe P. Theurillat
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Gene fusions involving the ERG transcription factor and point mutations in the ubiquitin ligase adaptor SPOP are two truncal mutations that are mutually exclusively present in prostate cancer. Here, the authors show that mutations in SPOP render pros
Externí odkaz:
https://doaj.org/article/f2c4c2cbe140413794b564af2e6c8775
Autor:
Simone Mosole, Katia Rossini, Helmut Kern, Stefan Löfler, Hannah Fruhmann, Michael Vogelauer, Samantha Burggraf, Martina Grim-Stieger, Ján Cvečka, Dušan Hamar, Milan Sedliak, Nejc Šarabon, Amber Pond, Donatella Biral, Ugo Carraro, Sandra Zampieri
Publikováno v:
European Journal of Translational Myology (2022)
In 2013 we presented results showing that at the histological level lifelong increased physical activity promotes reinnervation of muscle fibers in aging muscles. Indeed, in muscle biopsies from 70-year old men with a lifelong history of high-level p
Externí odkaz:
https://doaj.org/article/ea5cb6cdd4e846eb9ebb9f02f4dc02d5
Autor:
Sandra Furlan, Marina Campione, Marta Murgia, Simone Mosole, Francesco Argenton, Pompeo Volpe, Alessandra Nori
Publikováno v:
Frontiers in Neuroanatomy, Vol 14 (2020)
Calcium stores in neurons are heterogeneous in compartmentalization and molecular composition. Danio rerio (zebrafish) is an animal model with a simply folded cerebellum similar in cellular organization to that of mammals. The aim of the study was to
Externí odkaz:
https://doaj.org/article/63f3acbfb4ec41e697a19ffda6fff43b