Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABA(A) receptor encephalitis

Autor: Alexander M. Herrmann, Carmen Alcalá, Sven G. Meuth, Stefan Bittner, Simone M. Brändle, Nico Melzer, Frank Leypoldt, Amélie F Menke, David Gebert, Lisa Ann Gerdes, Klaus Dornmair, Bonaventura Casanova, Bianca Teegen, Tania Kümpfel, Hannah L. Pellkofer, Lars Komorowski, Reinhard Hohlfeld, Kathrin Held, Manuela Cerina, Eduardo Beltrán, Susanne Weber

Publikováno v: Proc Natl Acad Sci U S A
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Encephalitis associated with antibodies against the neuronal gamma-aminobutyric acid A receptor (GABA A -R) is a rare form of autoimmune encephalitis. The pathogenesis is still unknown but autoimmune mechanisms were surmised. Here we identified a str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d272c77579b51bd8d9c197ed92f6b3
https://europepmc.org/articles/PMC7936355/

Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins

Autor: Reinhard Mentele, Mohsen Khademi, Makbule Senel, Friedrich Lottspeich, Birgit Obermeier, Wolfgang Kristoferitsch, H. Wekerle, Hayrettin Tumani, Klaus Dornmair, Tomas Olsson, Jessica Bruder, Simone M. Brändle, Reinhard Hohlfeld

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Oligoclonal Ig bands (OCBs) of the cerebrospinal fluid are a hallmark of multiple sclerosis (MS), a disabling inflammatory disease of the central nervous system (CNS). OCBs are locally produced by clonally expanded antigen-experienced B cells and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc920c2a6b13aa446bf0a090b66baf9
https://doi.org/10.1073/pnas.1522730113