Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Simone Lanfredini"'
CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis
Autor:
Huw J. Morgan, Elise Rees, Simone Lanfredini, Kate A. Powell, Jasmine Gore, Alex Gibbs, Charlotte Lovatt, Gemma E. Davies, Carlotta Olivero, Boris Y. Shorning, Giusy Tornillo, Alex Tonks, Richard Darley, Eddie C.Y. Wang, Girish K. Patel
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
The basis of immune evasion, a hallmark of cancer, can differ even when cancers arise from one cell type such as in the human skin keratinocyte carcinomas: basal and squamous cell carcinoma. Here we showed that the basal cell carcinoma tumor–initia
Externí odkaz:
https://doaj.org/article/ea703a273eba40cda8c0b9d20462893e
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Field cancerisation was originally described as a basis for multiple head and neck squamous cell carcinoma (HNSCC) and is a pre-malignant phenomenon that is frequently attributable to oncogenic human papillomavirus (HPV) infection. Our work on β-HPV
Externí odkaz:
https://doaj.org/article/c440b09770644176b4d6a9e1ce326d32
Autor:
Cinzia Borgogna, Carlotta Olivero, Simone Lanfredini, Federica Calati, Marco De Andrea, Elisa Zavattaro, Paola Savoia, Elena Trisolini, Renzo Boldorini, Girish K. Patel, Marisa Gariglio
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Many malignancies that occur in high excess in kidney transplant recipients (KTRs) are due to viruses that thrive in the setting of immunosuppression. Keratinocyte carcinoma (KC), the most frequently occurring cancer type in KTR, has been associated
Externí odkaz:
https://doaj.org/article/86b1d25b933e444fb3045d410e727d4f
Abstract 2885: RASSF1A133Sresulting from the prevalent SNP rs2073498 is associated with Treg defects
Publikováno v:
Cancer Research. 83:2885-2885
Rs2073498 is a prevalent (~10% population) single nucleotide polymorphism (SNP) that leads to A133S missense mutation in tumor suppressor and Hippo Signaling Pathway scaffold protein RASSF1A. Recent reports have illustrated the crucial involvement of
Autor:
A Mukhtar, Carlotta Olivero, Huw Morgan, A. Benketah, Girish Khandubhai Patel, Emma Rees, S. Ziaj, Simone Lanfredini
Publikováno v:
Clinical and Experimental Dermatology. 45:417-425
Background Identification of human basal cell carcinoma (BCC) cancer stem cells and cellular hierarchy inherently implies the presence of differentiation. By conventional histological analysis, BCC demonstrates tumour nodules that appear relatively h
Autor:
Angelos Papaspyropoulos, Andriani Angelopoulou, Ioanna Mourkioti, Aikaterini Polyzou, Daniela Pankova, Konstantinos Toskas, Simone Lanfredini, Anastasia A Pantazaki, Nefeli Lagopati, Athanassios Kotsinas, Konstantinos Evangelou, Efstathios Chronopoulos, Eric O’Neill, Vassilis Gorgoulis
Publikováno v:
EMBO Rep
RASSF1A promoter methylation has been correlated with tumor dedifferentiation and aggressive oncogenic behavior. Nevertheless, the underlying mechanism of RASSF1A‐dependent tumor dedifferentiation remains elusive. Here, we show that RASSF1A directl
Autor:
Michael Eyres, Christine Blancher, Andrew Blake, Frances Willenbrock, Dimitris Vavoulis, Michael Silva, Zahir Soonawalla, Daniel S.T. Hughes, Aswin George Abraham, Haonan Xu, Stephanie Jones, Asmita Thapa, S. M. Hughes, Robert D. Goldin, Eric O'Neill, Anna Schuh, Ahmad Sabbagh, Adam Burns, Simone Lanfredini, Clare Verrill, Somnath Mukherjee, Zenobia D’Costa, Tim Maughan, Aline Hubert
Publikováno v:
668.e16
BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) is characterized by advanced disease stage at presentation, aggressive disease biology, and resistance to therapy, resulting in an extremely poor 5-year survival rate of
Autor:
Girish Khandubhai Patel, Emma Rees, Huw Morgan, Simone Lanfredini, A. Benketah, Carlotta Olivero, S. Ziaj, A Mukhtar
Publikováno v:
Clinical and experimental dermatologyReferences. 45(3)
Background\ud Consistent with cancer stem cell driven pattern of growth, human basal cell carcinomas (BCCs) demonstrate differentiation along hair follicle (HF) lineages.\ud Aim\ud To define the pattern of differentiation and therapeutic targets that
Publikováno v:
Biochemical Society transactions. 47(4)
The pancreas is a gland composed mainly by endocrine and exocrine cells, giving rise to three main tumour types. Pancreatic neuroendocrine tumour or PNET arise from the endocrine portion of the pancreas. On the contrary, pancreatic exocrine neoplasms
Autor:
Paul, Kinchesh, Philip D, Allen, Stuart, Gilchrist, Veerle, Kersemans, Simone, Lanfredini, Asmita, Thapa, Eric, O'Neill, Sean C, Smart
Publikováno v:
Magnetic Resonance Imaging
Purpose Multi-slice scanning in the abdomen and thorax of small animals is compromised by the effects of respiration unless imaging and respiration are synchronised. To avoid the signal modulations that result from respiration motion and a variable T